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Similar articles for PubMed (Select 9005852)


Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate.

Franke TF, Kaplan DR, Cantley LC, Toker A.

Science. 1997 Jan 31;275(5300):665-8.


The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.

Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN.

Cell. 1995 Jun 2;81(5):727-36.


Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.

Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, Cohen P, Alessi DR, Lucocq J.

Biochem J. 1999 Feb 1;337 ( Pt 3):575-83.


Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation.

Stratford S, DeWald DB, Summers SA.

Biochem J. 2001 Mar 1;354(Pt 2):359-68.


The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.

Ivetac I, Munday AD, Kisseleva MV, Zhang XM, Luff S, Tiganis T, Whisstock JC, Rowe T, Majerus PW, Mitchell CA.

Mol Biol Cell. 2005 May;16(5):2218-33. Epub 2005 Feb 16.


Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT.

Science. 1998 Jan 30;279(5351):710-4.


Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation.

James SR, Downes CP, Gigg R, Grove SJ, Holmes AB, Alessi DR.

Biochem J. 1996 May 1;315 ( Pt 3):709-13.


Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk.

Saito K, Scharenberg AM, Kinet JP.

J Biol Chem. 2001 May 11;276(19):16201-6. Epub 2001 Jan 30.


The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.

Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9867-72. Epub 2003 Aug 1.


Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G, Stokoe D.

Curr Biol. 1998 Oct 22;8(21):1195-8.


Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.

Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM.

Biochem J. 2003 Nov 1;375(Pt 3):531-8.


Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation.

Kohn AD, Takeuchi F, Roth RA.

J Biol Chem. 1996 Sep 6;271(36):21920-6.


Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.

Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT.

Science. 1997 Jul 25;277(5325):567-70.

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