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Items: 1 to 20 of 378

1.

Antitumor agents. 3. Synthesis and biological activity of 4 beta-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.

Terada T, Fujimoto K, Nomura M, Yamashita J, Wierzba K, Yamazaki R, Shibata J, Sugimoto Y, Yamada Y, Kobunai T, et al.

J Med Chem. 1993 Jun 11;36(12):1689-99.

PMID:
8389875
2.

Antitumor agents. II: Regio- and stereospecific syntheses of 1-beta-alkyl-1-desoxypodophyllotoxin derivatives and biological activity.

Terada T, Fujimoto K, Nomura M, Yamashita J, Wierzba K, Kobunai T, Takeda S, Minami Y, Yoshida K, Yamaguchi H, et al.

Chem Pharm Bull (Tokyo). 1993 May;41(5):907-12.

PMID:
8393386
3.
4.

Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents.

Terada T, Fujimoto K, Nomura M, Yamashita J, Kobunai T, Takeda S, Wierzba K, Yamada Y, Yamaguchi H.

Chem Pharm Bull (Tokyo). 1992 Oct;40(10):2720-7.

PMID:
1334447
5.

Novel carbamate derivatives of 4-beta-amino-4'-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation.

Duca M, Arimondo PB, Léonce S, Pierré A, Pfeiffer B, Monneret C, Dauzonne D.

Org Biomol Chem. 2005 Mar 21;3(6):1074-80. Epub 2005 Feb 18.

PMID:
15750651
7.

Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin.

Guianvarc'h D, Duca M, Boukarim C, Kraus-Berthier L, Léonce S, Pierré A, Pfeiffer B, Renard P, Arimondo PB, Monneret C, Dauzonne D.

J Med Chem. 2004 Apr 22;47(9):2365-74.

PMID:
15084135
8.

Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer.

Utsugi T, Shibata J, Sugimoto Y, Aoyagi K, Wierzba K, Kobunai T, Terada T, Oh-hara T, Tsuruo T, Yamada Y.

Cancer Res. 1996 Jun 15;56(12):2809-14.

9.

Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.

Xiao Z, Bastow KF, Vance JR, Lee KH.

Bioorg Med Chem. 2004 Jun 15;12(12):3339-44.

PMID:
15158802
10.

Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611.

Daley L, Guminski Y, Demerseman P, Kruczynski A, Etiévant C, Imbert T, Hill BT, Monneret C.

J Med Chem. 1998 Nov 5;41(23):4475-85.

PMID:
9804687
12.

Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.

Xiao Z, Bastow KF, Vance JR, Sidwell RS, Wang HK, Chen MS, Shi Q, Lee KH.

J Med Chem. 2004 Oct 7;47(21):5140-8.

PMID:
15456257
13.

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.

Kuo SC, Lee HZ, Juang JP, Lin YT, Wu TS, Chang JJ, Lednicer D, Paull KD, Lin CM, Hamel E, et al.

J Med Chem. 1993 Apr 30;36(9):1146-56.

PMID:
8387598
14.

Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives.

Duca M, Guianvarc'h D, Meresse P, Bertounesque E, Dauzonne D, Kraus-Berthier L, Thirot S, Léonce S, Pierré A, Pfeiffer B, Renard P, Arimondo PB, Monneret C.

J Med Chem. 2005 Jan 27;48(2):593-603.

PMID:
15658872
16.

Synthesis and biological evaluation of new 4β-anilino-4'-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents.

Wang L, Yang F, Yang X, Guan X, Hu C, Liu T, He Q, Yang B, Hu Y.

Eur J Med Chem. 2011 Jan;46(1):285-96. doi: 10.1016/j.ejmech.2010.11.016. Epub 2010 Nov 19.

PMID:
21145139
17.
18.

Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II.

Lee KH, Beers SA, Mori M, Wang ZQ, Kuo YH, Li L, Liu SY, Chang JY, Han FS, Cheng YC.

J Med Chem. 1990 May;33(5):1364-8.

PMID:
2158562
19.

Synthesis and antitumor activity of structural analogues of the epipodophyllotoxins.

Klein LL, Yeung CM, Chu DT, McDonald EJ, Clement JJ, Plattner JJ.

J Med Chem. 1991 Mar;34(3):984-92.

PMID:
2002477
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