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Results: 1 to 20 of 371

Similar articles for PubMed (Select 7981204)

1.

Design of potent bivalent thrombin inhibitors based on hirudin sequence: incorporation of nonsubstrate-type active site inhibitors.

Tsuda Y, Cygler M, Gibbs BF, Pedyczak A, Féthière J, Yue SY, Konishi Y.

Biochemistry. 1994 Dec 6;33(48):14443-51.

PMID:
7981204
2.

Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.

Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y.

Biochemistry. 2000 Mar 7;39(9):2384-91.

PMID:
10694407
3.

Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.

Féthière J, Tsuda Y, Coulombe R, Konishi Y, Cygler M.

Protein Sci. 1996 Jun;5(6):1174-83.

4.

Interactions of hirudin-based inhibitor with thrombin: critical role of the IleH59 side chain of the inhibitor.

Tsuda Y, Szewczuk Z, Wang J, Yue SY, Purisima E, Konishi Y.

Biochemistry. 1995 Jul 11;34(27):8708-14.

PMID:
7612610
5.

Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.

Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M.

Proteins. 1993 Nov;17(3):252-65.

PMID:
8272424
6.

Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.

Skordalakes E, Elgendy S, Goodwin CA, Green D, Scully MF, Kakkar VV, Freyssinet JM, Dodson G, Deadman JJ.

Biochemistry. 1998 Oct 13;37(41):14420-7.

PMID:
9772168
7.

Nonpolar interactions of thrombin S' subsites with its bivalent inhibitor: methyl scan of the inhibitor linker.

Slon-Usakiewicz JJ, Purisima E, Tsuda Y, Sulea T, Pedyczak A, Féthière J, Cygler M, Konishi Y.

Biochemistry. 1997 Nov 4;36(44):13494-502.

PMID:
9354617
8.

Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin.

Maraganore JM, Bourdon P, Jablonski J, Ramachandran KL, Fenton JW 2nd.

Biochemistry. 1990 Jul 31;29(30):7095-101.

PMID:
2223763
9.

A new class of potent thrombin inhibitors that incorporates a scissile pseudopeptide bond.

DiMaio J, Ni F, Gibbs B, Konishi Y.

FEBS Lett. 1991 Apr 22;282(1):47-52.

10.

Design of a linker for trivalent thrombin inhibitors: interaction of the main chain of the linker with thrombin.

Szewczuk Z, Gibbs BF, Yue SY, Purisima E, Zdanov A, Cygler M, Konishi Y.

Biochemistry. 1993 Apr 6;32(13):3396-404.

PMID:
8461303
11.

In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.

Costanzo MJ, Almond HR Jr, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.

J Med Chem. 2005 Mar 24;48(6):1984-2008. Erratum in: J Med Chem. 2007 Nov 15;50(23):5868.

PMID:
15771442
12.
13.

Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.

De Simone G, Lombardi A, Galdiero S, Nastri F, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V.

Protein Sci. 1998 Feb;7(2):243-53.

14.

Rational design and selection of bivalent peptide ligands of thrombin incorporating P4-P1 tetrapeptide sequences: from good substrates to potent inhibitors.

Su Z, Vinogradova A, Koutychenko A, Tolkatchev D, Ni F.

Protein Eng Des Sel. 2004 Aug;17(8):647-57. Epub 2004 Sep 9.

15.

Hirulog peptides with scissile bond replacements resistant to thrombin cleavage.

Kline T, Hammond C, Bourdon P, Maraganore JM.

Biochem Biophys Res Commun. 1991 Jun 28;177(3):1049-55.

PMID:
2059196
16.

Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin.

Rehse PH, Steinmetzer T, Li Y, Konishi Y, Cygler M.

Biochemistry. 1995 Sep 12;34(36):11537-44.

PMID:
7547884
17.

Structure-based understanding of ligand affinity using human thrombin as a model system.

Nienaber VL, Mersinger LJ, Kettner CA.

Biochemistry. 1996 Jul 30;35(30):9690-9.

PMID:
8703940
18.

Rational design of hirulog-type inhibitors of thrombin.

Egner U, Hoyer GA, Schleuning WD.

J Comput Aided Mol Des. 1994 Oct;8(5):479-90.

PMID:
7876896
19.

Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.

Qiu X, Padmanabhan KP, Carperos VE, Tulinsky A, Kline T, Maraganore JM, Fenton JW 2nd.

Biochemistry. 1992 Dec 1;31(47):11689-97.

PMID:
1445905
20.

Design and evaluation of novel bivalent thrombin inhibitors based on amidinophenylalanines.

Steinmetzer T, Renatus M, Künzel S, Eichinger A, Bode W, Wikström P, Hauptmann J, Stürzebecher J.

Eur J Biochem. 1999 Oct;265(2):598-605.

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