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Items: 1 to 20 of 120

1.

The catalytic mechanism and structure of thymidylate synthase.

Carreras CW, Santi DV.

Annu Rev Biochem. 1995;64:721-62. Review.

PMID:
7574499
3.

Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.

Sotelo-Mundo RR, Changchien L, Maley F, Montfort WR.

J Biochem Mol Toxicol. 2006;20(2):88-92. Erratum in: J Biochem Mol Toxicol. 2006;20(3):150.

PMID:
16615077
4.

Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate.

Costi PM, Liu L, Finer-Moore JS, Stroud RM, Santi DV.

Biochemistry. 1996 Apr 2;35(13):3944-9.

PMID:
8672425
5.

Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase.

Kealey JT, Eckstein J, Santi DV.

Chem Biol. 1995 Sep;2(9):609-14.

7.

The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.

Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM.

Biochemistry. 2006 Jun 20;45(24):7415-28.

8.
9.

Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.

Finer-Moore JS, Liu L, Birdsall DL, Brem R, Apfeld J, Santi DV, Stroud RM.

J Mol Biol. 1998 Feb 13;276(1):113-29.

PMID:
9514716
10.

A novel dCMP methylase by engineering thymidylate synthase.

Agarwalla S, LaPorte S, Liu L, Finer-Moore J, Stroud RM, Santi DV.

Biochemistry. 1997 Dec 16;36(50):15909-17.

PMID:
9398324
11.
12.

Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.

Finer-Moore JS, Liu L, Schafmeister CE, Birdsall DL, Mau T, Santi DV, Stroud RM.

Biochemistry. 1996 Apr 23;35(16):5125-36.

PMID:
8611496
13.

Structural determinants for the intracellular degradation of human thymidylate synthase.

Forsthoefel AM, Peña MM, Xing YY, Rafique Z, Berger FG.

Biochemistry. 2004 Feb 24;43(7):1972-9.

PMID:
14967037
14.
15.

An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.

Sage CR, Rutenber EE, Stout TJ, Stroud RM.

Biochemistry. 1996 Dec 17;35(50):16270-81.

PMID:
8973201
16.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Phan J, Steadman DJ, Koli S, Ding WC, Minor W, Dunlap RB, Berger SH, Lebioda L.

J Biol Chem. 2001 Apr 27;276(17):14170-7. Epub 2001 Jan 24.

17.

Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes.

Steadman DJ, Spencer HT, Dunlap RB, Berger SH.

Biochemistry. 1999 Apr 27;38(17):5582-7.

PMID:
10220346
18.

Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.

Strop P, Changchien L, Maley F, Montfort WR.

Protein Sci. 1997 Dec;6(12):2504-11.

19.

The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.

Anderson AC, Perry KM, Freymann DM, Stroud RM.

J Mol Biol. 2000 Mar 31;297(3):645-57.

PMID:
10731418
20.
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