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Results: 1 to 20 of 133

1.

Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells.

Myers DE, Jun X, Waddick KG, Forsyth C, Chelstrom LM, Gunther RL, Tumer NE, Bolen J, Uckun FM.

Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9575-9. Erratum in: Proc Natl Acad Sci U S A 1996 Feb 6;93(3):1357.

PMID:
7568175
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases.

Uckun FM, Evans WE, Forsyth CJ, Waddick KG, Ahlgren LT, Chelstrom LM, Burkhardt A, Bolen J, Myers DE.

Science. 1995 Feb 10;267(5199):886-91.

PMID:
7531365
[PubMed - indexed for MEDLINE]
3.

Treatment of therapy-refractory B-lineage acute lymphoblastic leukemia with an apoptosis-inducing CD19-directed tyrosine kinase inhibitor.

Uckun FM, Messinger Y, Chen CL, O'Neill K, Myers DE, Goldman F, Hurvitz C, Casper JT, Levine A.

Clin Cancer Res. 1999 Dec;5(12):3906-13.

PMID:
10632319
[PubMed - indexed for MEDLINE]
Free Article
4.

Engagement of the CD19 receptor on human B-lineage leukemia cells activates LCK tyrosine kinase and facilitates radiation-induced apoptosis.

Waddick KG, Chae HP, Tuel-Ahlgren L, Jarvis LJ, Dibirdik I, Myers DE, Uckun FM.

Radiat Res. 1993 Dec;136(3):313-9.

PMID:
7506428
[PubMed - indexed for MEDLINE]
5.

In vivo toxicity and pharmacokinetic features of B43 (anti-CD19)-genistein immunoconjugate in nonhuman primates.

Messinger Y, Yanishevski Y, Ek O, Zeren T, Waurzyniak B, Gunther R, Chelstrom L, Chandan-Langlie M, Schneider E, Myers DE, Evans W, Uckun FM.

Clin Cancer Res. 1998 Jan;4(1):165-70.

PMID:
9516966
[PubMed - indexed for MEDLINE]
Free Article
6.

CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol 3-kinase.

Kitanaka A, Ito C, Coustan-Smith E, Campana D.

J Immunol. 1997 Jul 1;159(1):184-92.

PMID:
9200454
[PubMed - indexed for MEDLINE]
7.

Combined therapeutic efficacy of the thymidylate synthase inhibitor ZD1694 (Tomudex) and the immunotoxin B43(anti-CD19)-PAP in a SCID mouse model of human B-lineage acute lymphoblastic leukemia.

Ek O, Reaman GH, Crankshaw DL, Chelstrom LM, Myers DE, Uckun FM.

Leuk Lymphoma. 1998 Feb;28(5-6):509-14.

PMID:
9613980
[PubMed - indexed for MEDLINE]
8.

Effective immunochemotherapy of CALLA+C mu+ human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide.

Uckun FM, Chelstrom LM, Finnegan D, Tuel-Ahlgren L, Manivel C, Irvin JD, Myers DE, Gunther R.

Blood. 1992 Jun 15;79(12):3116-29.

PMID:
1375841
[PubMed - indexed for MEDLINE]
Free Article
9.

In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency.

Uckun FM, Manivel C, Arthur D, Chelstrom LM, Finnegan D, Tuel-Ahlgren L, Irvin JD, Myers DE, Gunther R.

Blood. 1992 May 1;79(9):2201-14.

PMID:
1373967
[PubMed - indexed for MEDLINE]
Free Article
10.

Clinical pharmacokinetics of the CD19 receptor-directed tyrosine kinase inhibitor B43-Genistein in patients with B-lineage lymphoid malignancies.

Chen CL, Levine A, Rao A, O'Neill K, Messinger Y, Myers DE, Goldman F, Hurvitz C, Casper JT, Uckun FM.

J Clin Pharmacol. 1999 Dec;39(12):1248-55.

PMID:
10586390
[PubMed - indexed for MEDLINE]
11.

In vivo toxicity and pharmacokinetic features of B43(Anti-CD19)-Genistein immunoconjugate.

Ek O, Yanishevski Y, Zeren T, Waurzyniak B, Gunther R, Chelstrom L, Chandan-Langlie M, Schneider E, Myers DE, Evans W, Uckun FM.

Leuk Lymphoma. 1998 Jul;30(3-4):389-94.

PMID:
9713969
[PubMed - indexed for MEDLINE]
12.

In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against BCL-1 murine B-cell leukemia.

Uckun FM, Chelstrom LM, Irvin JD, Finnegan D, Gunther R, Young J, Kuebelbeck V, Myers DE, Houston LL.

Blood. 1992 May 15;79(10):2649-61.

PMID:
1375109
[PubMed - indexed for MEDLINE]
Free Article
13.

A superantigen-antibody fusion protein for T-cell immunotherapy of human B-lineage malignancies.

Gidlöf C, Dohlsten M, Lando P, Kalland T, Sundström C, Tötterman TH.

Blood. 1997 Mar 15;89(6):2089-97.

PMID:
9058731
[PubMed - indexed for MEDLINE]
Free Article
14.

Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins.

Uckun FM, Jaszcz W, Ambrus JL, Fauci AS, Gajl-Peczalska K, Song CW, Wick MR, Myers DE, Waddick K, Ledbetter JA.

Blood. 1988 Jan;71(1):13-29.

PMID:
3257143
[PubMed - indexed for MEDLINE]
Free Article
15.

Therapy of human B-cell lymphoma bearing SCID mice is more effective with anti-CD19- and anti-CD38-saporin immunotoxins used in combination than with either immunotoxin used alone.

Flavell DJ, Boehm DA, Emery L, Noss A, Ramsay A, Flavell SU.

Int J Cancer. 1995 Jul 28;62(3):337-44.

PMID:
7543082
[PubMed - indexed for MEDLINE]
16.

Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells.

Scheuermann RH, Racila E, Tucker T, Yefenof E, Street NE, Vitetta ES, Picker LJ, Uhr JW.

Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4048-52.

PMID:
7513431
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

In vivo toxicity, pharmacokinetics, and anticancer activity of Genistein linked to recombinant human epidermal growth factor.

Uckun FM, Narla RK, Zeren T, Yanishevski Y, Myers DE, Waurzyniak B, Ek O, Schneider E, Messinger Y, Chelstrom LM, Gunther R, Evans W.

Clin Cancer Res. 1998 May;4(5):1125-34.

PMID:
9607569
[PubMed - indexed for MEDLINE]
Free Article
19.

Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin.

Gunther R, Chelstrom LM, Tuel-Ahlgren L, Simon J, Myers DE, Uckun FM.

Blood. 1995 May 1;85(9):2537-45.

PMID:
7537120
[PubMed - indexed for MEDLINE]
Free Article
20.

The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis.

Luciano F, Herrant M, Jacquel A, Ricci JE, Auberger P.

FASEB J. 2003 Apr;17(6):711-3. Epub 2003 Feb 5.

PMID:
12586738
[PubMed - indexed for MEDLINE]
Free Article

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