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Results: 1 to 20 of 173

1.

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase.

Loll PJ, Picot D, Garavito RM.

Nat Struct Biol. 1995 Aug;2(8):637-43.

PMID:
7552725
[PubMed - indexed for MEDLINE]
2.

Molecular basis for the inhibition of prostanoid biosynthesis by nonsteroidal anti-inflammatory agents.

Smith WL, DeWitt DL, Shimokawa T, Kraemer SA, Meade EA.

Stroke. 1990 Dec;21(12 Suppl):IV24-8.

PMID:
2175460
[PubMed - indexed for MEDLINE]
3.

O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions.

Loll PJ, Sharkey CT, O'Connor SJ, Dooley CM, O'Brien E, Devocelle M, Nolan KB, Selinsky BS, Fitzgerald DJ.

Mol Pharmacol. 2001 Dec;60(6):1407-13.

PMID:
11723249
[PubMed - indexed for MEDLINE]
Free Article
4.

Mechanistic insights into cyclooxygenase irreversible inactivation by aspirin.

Tosco P, Lazzarato L.

ChemMedChem. 2009 Jun;4(6):939-45. doi: 10.1002/cmdc.200800438.

PMID:
19301318
[PubMed - indexed for MEDLINE]
5.

Aspirin inhibition and acetylation of the plant cytochrome P450, allene oxide synthase, resembles that of animal prostaglandin endoperoxide H synthase.

Pan Z, Camara B, Gardner HW, Backhaus RA.

J Biol Chem. 1998 Jul 17;273(29):18139-45.

PMID:
9660772
[PubMed - indexed for MEDLINE]
Free Article
6.

Aspirin--now we can see it.

Allen KN.

Nat Med. 1995 Sep;1(9):882-3. Review. No abstract available.

PMID:
7585209
[PubMed - indexed for MEDLINE]
7.

The structures of prostaglandin endoperoxide H synthases-1 and -2.

Garavito RM, Malkowski MG, DeWitt DL.

Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:129-52. Review.

PMID:
12432914
[PubMed - indexed for MEDLINE]
8.
9.

Aspirin and inflammation.

[No authors listed]

Nat Struct Biol. 1995 Aug;2(8):605-6. No abstract available.

PMID:
7552717
[PubMed - indexed for MEDLINE]
10.
11.

Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.

Loll PJ, Picot D, Ekabo O, Garavito RM.

Biochemistry. 1996 Jun 11;35(23):7330-40.

PMID:
8652509
[PubMed - indexed for MEDLINE]
12.

Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.

Kalgutkar AS, Kozak KR, Crews BC, Hochgesang GP Jr, Marnett LJ.

J Med Chem. 1998 Nov 19;41(24):4800-18.

PMID:
9822550
[PubMed - indexed for MEDLINE]
13.

Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid.

Bhattacharyya DK, Lecomte M, Dunn J, Morgans DJ, Smith WL.

Arch Biochem Biophys. 1995 Feb 20;317(1):19-24.

PMID:
7872783
[PubMed - indexed for MEDLINE]
14.

Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.

Selinsky BS, Gupta K, Sharkey CT, Loll PJ.

Biochemistry. 2001 May 1;40(17):5172-80.

PMID:
11318639
[PubMed - indexed for MEDLINE]
15.

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.

Picot D, Loll PJ, Garavito RM.

Nature. 1994 Jan 20;367(6460):243-9.

PMID:
8121489
[PubMed - indexed for MEDLINE]
16.

Structural basis of the dynamic mechanism of ligand binding to cyclooxygenase.

Llorens O, Perez JJ, Palomer A, Mauleon D.

Bioorg Med Chem Lett. 1999 Oct 4;9(19):2779-84.

PMID:
10522690
[PubMed - indexed for MEDLINE]
17.

Interaction of PGH synthase isozymes-1 and -2 with nonsteroidal anti-inflammatory drugs.

Smith WL, Meade EA, Dewitt DL.

Adv Exp Med Biol. 1997;400A:189-96. No abstract available.

PMID:
9547557
[PubMed - indexed for MEDLINE]
18.

Aspirin-like molecules that covalently inactivate cyclooxygenase-2.

Kalgutkar AS, Crews BC, Rowlinson SW, Garner C, Seibert K, Marnett LJ.

Science. 1998 May 22;280(5367):1268-70.

PMID:
9596581
[PubMed - indexed for MEDLINE]
Free Article
19.

Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.

Xiao G, Tsai AL, Palmer G, Boyar WC, Marshall PJ, Kulmacz RJ.

Biochemistry. 1997 Feb 18;36(7):1836-45.

PMID:
9048568
[PubMed - indexed for MEDLINE]
20.

Structure-based QSAR study on differential inhibition of human prostaglandin endoperoxide H synthase-2 (COX-2) by nonsteroidal anti-inflammatory drugs.

Pouplana R, Lozano JJ, PĂ©rez C, Ruiz J.

J Comput Aided Mol Des. 2002 Oct;16(10):683-709.

PMID:
12650588
[PubMed - indexed for MEDLINE]

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