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Results: 1 to 20 of 159

1.

Proposed heparin binding site in antithrombin based on arginine 47. A new variant Rouen-II, 47 Arg to Ser.

Borg JY, Owen MC, Soria C, Soria J, Caen J, Carrell RW.

J Clin Invest. 1988 Apr;81(4):1292-6.

PMID:
3350974
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Heparin binding defect in a new antithrombin III variant: Rouen, 47 Arg to His.

Owen MC, Borg JY, Soria C, Soria J, Caen J, Carrell RW.

Blood. 1987 May;69(5):1275-9.

PMID:
3567355
[PubMed - indexed for MEDLINE]
Free Article
3.

Antithrombin Rouen-IV 24 Arg----Cys. The amino-terminal contribution to heparin binding.

Borg JY, Brennan SO, Carrell RW, George P, Perry DJ, Shaw J.

FEBS Lett. 1990 Jun 18;266(1-2):163-6.

PMID:
2365065
[PubMed - indexed for MEDLINE]
Free Article
4.

Deletion of P1 arginine in a novel antithrombin variant (antithrombin London) abolishes inhibitory activity but enhances heparin affinity and is associated with early onset thrombosis.

Raja SM, Chhablani N, Swanson R, Thompson E, Laffan M, Lane DA, Olson ST.

J Biol Chem. 2003 Apr 18;278(16):13688-95. Epub 2003 Feb 18.

PMID:
12591924
[PubMed - indexed for MEDLINE]
Free Article
6.

A novel amino acid substitution in the reactive site of a congenital variant antithrombin. Antithrombin pescara, ARG393 to pro, caused by a CGT to CCT mutation.

Lane DA, Erdjument H, Thompson E, Panico M, Di Marzo V, Morris HR, Leone G, De Stefano V, Thein SL.

J Biol Chem. 1989 Jun 15;264(17):10200-4.

PMID:
2722864
[PubMed - indexed for MEDLINE]
Free Article
7.

Molecular characterization of antithrombin Barcelona-2: 47 arginine to cysteine.

Owen MC, Shaw GJ, Grau E, Fontcuberta J, Carrell RW, Boswell DR.

Thromb Res. 1989 Aug 15;55(4):451-7.

PMID:
2814937
[PubMed - indexed for MEDLINE]
8.

Antithrombin Glasgow, 393 Arg to His: a P1 reactive site variant with increased heparin affinity but no thrombin inhibitory activity.

Owen MC, Beresford CH, Carrell RW.

FEBS Lett. 1988 Apr 25;231(2):317-20.

PMID:
3360140
[PubMed - indexed for MEDLINE]
Free Article
9.

Pleiotropic effects of antithrombin strand 1C substitution mutations.

Lane DA, Olds RJ, Conard J, Boisclair M, Bock SC, Hultin M, Abildgaard U, Ireland H, Thompson E, Sas G, et al.

J Clin Invest. 1992 Dec;90(6):2422-33.

PMID:
1469094
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Important role of arginine 129 in heparin-binding site of antithrombin III. Identification of a novel mutation arginine 129 to glutamine.

Gandrille S, Aiach M, Lane DA, Vidaud D, Molho-Sabatier P, Caso R, de Moerloose P, Fiessinger JN, Clauser E.

J Biol Chem. 1990 Nov 5;265(31):18997-9001.

PMID:
2229057
[PubMed - indexed for MEDLINE]
Free Article
11.

Antithrombin III Toyama: replacement of arginine-47 by cysteine in hereditary abnormal antithrombin III that lacks heparin-binding ability.

Koide T, Odani S, Takahashi K, Ono T, Sakuragawa N.

Proc Natl Acad Sci U S A. 1984 Jan;81(2):289-93.

PMID:
6582486
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Antithrombins Southport (Leu 99 to Val) and Vienna (Gln 118 to Pro): two novel antithrombin variants with abnormal heparin binding.

Chowdhury V, Mille B, Olds RJ, Lane DA, Watton J, Barrowcliffe TW, Pabinger I, Woodcock BE, Thein SL.

Br J Haematol. 1995 Mar;89(3):602-9.

PMID:
7734360
[PubMed - indexed for MEDLINE]
13.

Antithrombin III Kumamoto II; a single mutation at Arg393-His increased the affinity of antithrombin III for heparin.

Okajima K, Abe H, Wagatsuma M, Okabe H, Takatsuki K.

Am J Hematol. 1995 Jan;48(1):12-8.

PMID:
7832187
[PubMed - indexed for MEDLINE]
14.

Role of arginine 129 in heparin binding and activation of antithrombin.

Desai U, Swanson R, Bock SC, Bjork I, Olson ST.

J Biol Chem. 2000 Jun 23;275(25):18976-84.

PMID:
10764763
[PubMed - indexed for MEDLINE]
Free Article
15.

The role of Arg46 and Arg47 of antithrombin in heparin binding.

Arocas V, Bock SC, Olson ST, Björk I.

Biochemistry. 1999 Aug 3;38(31):10196-204.

PMID:
10433728
[PubMed - indexed for MEDLINE]
16.

Evidence that arginine-129 and arginine-145 are located within the heparin binding site of human antithrombin III.

Sun XJ, Chang JY.

Biochemistry. 1990 Sep 25;29(38):8957-62.

PMID:
2271571
[PubMed - indexed for MEDLINE]
17.

Mutation of the H-helix in antithrombin decreases heparin stimulation of protease inhibition.

Gonzales PR, Walston TD, Camacho LO, Kielar DM, Church FC, Rezaie AR, Cooper ST.

Biochim Biophys Acta. 2007 Nov;1774(11):1431-7. Epub 2007 Aug 30.

PMID:
17905675
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139.

Arocas V, Turk B, Bock SC, Olson ST, Björk I.

Biochemistry. 2000 Jul 25;39(29):8512-8.

PMID:
10913257
[PubMed - indexed for MEDLINE]
19.
20.

Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation.

Beauchamp NJ, Pike RN, Daly M, Butler L, Makris M, Dafforn TR, Zhou A, Fitton HL, Preston FE, Peake IR, Carrell RW.

Blood. 1998 Oct 15;92(8):2696-706.

PMID:
9763552
[PubMed - indexed for MEDLINE]
Free Article
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