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Items: 1 to 20 of 86

1.

Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse.

Palmer AL, Leykam VL, Larkin A, Krueger SK, Phillips IR, Shephard EA, Williams DE.

Pharmaceuticals (Basel). 2012;5(11):1147-59. doi: 10.3390/ph5111147.

2.

Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes.

Henderson MC, Siddens LK, Morré JT, Krueger SK, Williams DE.

Toxicol Appl Pharmacol. 2008 Dec 15;233(3):420-7. doi: 10.1016/j.taap.2008.09.017. Epub 2008 Oct 1.

3.

Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.

Francois AA, Nishida CR, de Montellano PR, Phillips IR, Shephard EA.

Drug Metab Dispos. 2009 Jan;37(1):178-86. doi: 10.1124/dmd.108.024158. Epub 2008 Oct 23.

4.

Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics.

Krueger SK, Siddens LK, Henderson MC, Andreasen EA, Tanguay RL, Pereira CB, Cabacungan ET, Hines RN, Ardlie KG, Williams DE.

Pharmacogenet Genomics. 2005 Apr;15(4):245-56.

5.

Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.

Whetstine JR, Yueh MF, McCarver DG, Williams DE, Park CS, Kang JH, Cha YN, Dolphin CT, Shephard EA, Phillips IR, Hines RN.

Toxicol Appl Pharmacol. 2000 Nov 1;168(3):216-24.

PMID:
11042094
6.

Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent.

Krueger SK, Siddens LK, Martin SR, Yu Z, Pereira CB, Cabacungan ET, Hines RN, Ardlie KG, Raucy JL, Williams DE.

Drug Metab Dispos. 2004 Dec;32(12):1337-40. Epub 2004 Sep 8.

7.
8.

Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide.

Siddens LK, Krueger SK, Henderson MC, Williams DE.

Biochem Pharmacol. 2014 May 1;89(1):141-7. doi: 10.1016/j.bcp.2014.02.006. Epub 2014 Feb 19.

9.
10.

[Development of antituberculous drugs: current status and future prospects].

Tomioka H, Namba K.

Kekkaku. 2006 Dec;81(12):753-74. Review. Japanese.

PMID:
17240921
11.

New times, new trends for ethionamide: In vitro evaluation of drug-loaded thermally carbonized porous silicon microparticles.

Vale N, Mäkilä E, Salonen J, Gomes P, Hirvonen J, Santos HA.

Eur J Pharm Biopharm. 2012 Jun;81(2):314-23. doi: 10.1016/j.ejpb.2012.02.017. Epub 2012 Mar 6.

PMID:
22418076
12.

S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2.

Henderson MC, Krueger SK, Siddens LK, Stevens JF, Williams DE.

Biochem Pharmacol. 2004 Sep 1;68(5):959-67.

PMID:
15294458
13.

The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein.

Dolphin CT, Beckett DJ, Janmohamed A, Cullingford TE, Smith RL, Shephard EA, Phillips IR.

J Biol Chem. 1998 Nov 13;273(46):30599-607.

14.

Genetic polymorphisms of flavin-containing monooxygenase (FMO).

Krueger SK, Williams DE, Yueh MF, Martin SR, Hines RN, Raucy JL, Dolphin CT, Shephard EA, Phillips IR.

Drug Metab Rev. 2002 Aug;34(3):523-32. Review.

PMID:
12214664
15.

The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.

Veeramah KR, Thomas MG, Weale ME, Zeitlyn D, Tarekegn A, Bekele E, Mendell NR, Shephard EA, Bradman N, Phillips IR.

Pharmacogenet Genomics. 2008 Oct;18(10):877-86. doi: 10.1097/FPC.0b013e3283097311.

16.

The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase.

Vannelli TA, Dykman A, Ortiz de Montellano PR.

J Biol Chem. 2002 Apr 12;277(15):12824-9. Epub 2002 Jan 31.

17.
18.

Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.

Krueger SK, Henderson MC, Siddens LK, VanDyke JE, Benninghoff AD, Karplus PA, Furnes B, Schlenk D, Williams DE.

Drug Metab Dispos. 2009 Aug;37(8):1785-91. doi: 10.1124/dmd.109.027201. Epub 2009 May 6.

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