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Evaluation of the INS-1 832/13 cell line as a beta-cell based screening system to assess pollutant effects on beta-cell function.

Hectors TL, Vanparys C, Pereira-Fernandes A, Martens GA, Blust R.

PLoS One. 2013;8(3):e60030. doi: 10.1371/journal.pone.0060030. Epub 2013 Mar 21.


Quercetin potentiates insulin secretion and protects INS-1 pancreatic β-cells against oxidative damage via the ERK1/2 pathway.

Youl E, Bardy G, Magous R, Cros G, Sejalon F, Virsolvy A, Richard S, Quignard JF, Gross R, Petit P, Bataille D, Oiry C.

Br J Pharmacol. 2010 Oct;161(4):799-814. doi: 10.1111/j.1476-5381.2010.00910.x.


Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents.

Arakawa M, Ebato C, Mita T, Hirose T, Kawamori R, Fujitani Y, Watada H.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):809-14. doi: 10.1016/j.bbrc.2009.10.054. Epub 2009 Oct 21.


Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells.

Lin Y, Sun X, Qiu L, Wei J, Huang Q, Fang C, Ye T, Kang M, Shen H, Dong S.

Cell Death Dis. 2013 Jan 17;4:e460. doi: 10.1038/cddis.2012.206.


Gene networks modified by sulphonylureas in beta cells: a pathway-based analysis of insulin secretion and cell death.

Magnusson NE, Dyrskjøt L, Grimm D, Wehland M, Pietsch J, Rungby J.

Basic Clin Pharmacol Toxicol. 2012 Oct;111(4):254-61. doi: 10.1111/j.1742-7843.2012.00902.x. Epub 2012 Jul 10.


Bisphenol A accelerates toxic amyloid formation of human islet amyloid polypeptide: a possible link between bisphenol A exposure and type 2 diabetes.

Gong H, Zhang X, Cheng B, Sun Y, Li C, Li T, Zheng L, Huang K.

PLoS One. 2013;8(1):e54198. doi: 10.1371/journal.pone.0054198. Epub 2013 Jan 23.


Effect of environmental contaminants on Beta cell function.

Makaji E, Raha S, Wade MG, Holloway AC.

Int J Toxicol. 2011 Aug;30(4):410-8. doi: 10.1177/1091581811405544. Epub 2011 Jun 24.


Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide.

Nguyen KH, Ta TN, Pham TH, Nguyen QT, Pham HD, Mishra S, Nyomba BL.

J Ethnopharmacol. 2012 Jul 13;142(2):488-95. doi: 10.1016/j.jep.2012.05.024. Epub 2012 May 23.


Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line.

Wei Q, Sun YQ, Zhang J.

Peptides. 2012 Sep;37(1):18-24. doi: 10.1016/j.peptides.2012.06.018. Epub 2012 Jul 7.


Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms.

Yang W, Yang G, Jia X, Wu L, Wang R.

J Physiol. 2005 Dec 1;569(Pt 2):519-31. Epub 2005 Sep 22.


Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.

Schvartz D, Couté Y, Brunner Y, Wollheim CB, Sanchez JC.

Mol Cell Proteomics. 2012 Aug;11(8):244-54. doi: 10.1074/mcp.M112.018051. Epub 2012 Mar 16.


Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways.

Tuo Y, Wang D, Li S, Chen C.

Endocrine. 2011 Apr;39(2):128-38. doi: 10.1007/s12020-010-9432-3. Epub 2010 Dec 15.


Exendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation.

Heller C, Kühn MC, Mülders-Opgenoorth B, Schott M, Willenberg HS, Scherbaum WA, Schinner S.

Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E864-72. doi: 10.1152/ajpendo.00144.2011. Epub 2011 Jul 19.


Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells.

Kamath V, Kyathanahalli CN, Jayaram B, Syed I, Olson LK, Ludwig K, Klumpp S, Krieglstein J, Kowluru A.

Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E276-86. doi: 10.1152/ajpendo.00091.2010. Epub 2010 May 25.


Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line.

Sturgess NC, Kozlowski RZ, Carrington CA, Hales CN, Ashford ML.

Br J Pharmacol. 1988 Sep;95(1):83-94.


Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion.

Cohen G, Riahi Y, Shamni O, Guichardant M, Chatgilialoglu C, Ferreri C, Kaiser N, Sasson S.

Diabetes. 2011 Nov;60(11):2830-42. doi: 10.2337/db11-0347. Epub 2011 Sep 6.


Metabolomic analysis of pancreatic beta cells following exposure to high glucose.

Wallace M, Whelan H, Brennan L.

Biochim Biophys Acta. 2013 Mar;1830(3):2583-90.

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