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Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans.

Park SO, Wamsley HL, Bae K, Hu Z, Li X, Choe SW, Slayton WB, Oh SP, Wagner KU, Sayeski PP.

PLoS One. 2013;8(3):e59675. doi: 10.1371/journal.pone.0059675. Epub 2013 Mar 27.


Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia.

Grisouard J, Hao-Shen H, Dirnhofer S, Wagner KU, Skoda RC.

Haematologica. 2014 Apr;99(4):e52-4. doi: 10.3324/haematol.2013.100016. Epub 2014 Feb 7. No abstract available.


Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.

Neubauer H, Cumano A, Müller M, Wu H, Huffstadt U, Pfeffer K.

Cell. 1998 May 1;93(3):397-409.


FADD deficiency impairs early hematopoiesis in the bone marrow.

Rosenberg S, Zhang H, Zhang J.

J Immunol. 2011 Jan 1;186(1):203-13. doi: 10.4049/jimmunol.1000648. Epub 2010 Nov 29.


Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model.

Kubovcakova L, Lundberg P, Grisouard J, Hao-Shen H, Romanet V, Andraos R, Murakami M, Dirnhofer S, Wagner KU, Radimerski T, Skoda RC.

Blood. 2013 Feb 14;121(7):1188-99. doi: 10.1182/blood-2012-03-415646. Epub 2012 Dec 20.


Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis.

Sánchez-Aguilera A, Arranz L, Martín-Pérez D, García-García A, Stavropoulou V, Kubovcakova L, Isern J, Martín-Salamanca S, Langa X, Skoda RC, Schwaller J, Méndez-Ferrer S.

Cell Stem Cell. 2014 Dec 4;15(6):791-804. doi: 10.1016/j.stem.2014.11.002.


Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice.

Krempler A, Qi Y, Triplett AA, Zhu J, Rui H, Wagner KU.

Genesis. 2004 Sep;40(1):52-7.


Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy.

Presley CA, Lee AW, Kastl B, Igbinosa I, Yamada Y, Fishman GI, Gutstein DE, Cancelas JA.

Cell Commun Adhes. 2005 Jul-Dec;12(5-6):307-17.


Hematopoietic defects in mice lacking the sialomucin CD34.

Cheng J, Baumhueter S, Cacalano G, Carver-Moore K, Thibodeaux H, Thomas R, Broxmeyer HE, Cooper S, Hague N, Moore M, Lasky LA.

Blood. 1996 Jan 15;87(2):479-90.


Essential role of the RNA-binding protein HuR in progenitor cell survival in mice.

Ghosh M, Aguila HL, Michaud J, Ai Y, Wu MT, Hemmes A, Ristimaki A, Guo C, Furneaux H, Hla T.

J Clin Invest. 2009 Dec;119(12):3530-43. doi: 10.1172/JCI38263. Epub 2009 Nov 2.


Perinatal synthetic lethality and hematopoietic defects in compound mafG::mafK mutant mice.

Onodera K, Shavit JA, Motohashi H, Yamamoto M, Engel JD.

EMBO J. 2000 Mar 15;19(6):1335-45.


JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.

Hasan S, Lacout C, Marty C, Cuingnet M, Solary E, Vainchenker W, Villeval JL.

Blood. 2013 Aug 22;122(8):1464-77. doi: 10.1182/blood-2013-04-498956. Epub 2013 Jul 17.


Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.

Akada H, Akada S, Hutchison RE, Sakamoto K, Wagner KU, Mohi G.

Stem Cells. 2014 Jul;32(7):1878-89. doi: 10.1002/stem.1711.


Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling.

Jenkins BJ, Quilici C, Roberts AW, Grail D, Dunn AR, Ernst M.

Exp Hematol. 2002 Nov;30(11):1248-56.


Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.

Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T.

Haematologica. 2015 Apr;100(4):439-51. doi: 10.3324/haematol.2014.119537. Epub 2014 Dec 31.


Leukemic stromal hematopoietic microenvironment negatively regulates the normal hematopoiesis in mouse model of leukemia.

Basak P, Chatterjee S, Das P, Das M, Pereira JA, Dutta RK, Chaklader M, Chaudhuri S, Law S.

Chin J Cancer. 2010 Dec;29(12):969-79.


Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice.

Wagner KU, Krempler A, Triplett AA, Qi Y, George NM, Zhu J, Rui H.

Mol Cell Biol. 2004 Jun;24(12):5510-20.


Osteomyelosclerosis, anemia and extramedullary hematopoiesis in mice lacking the transcription factor NFATc2.

Bauer W, Rauner M, Haase M, Kujawski S, Arabanian LS, Habermann I, Hofbauer LC, Ehninger G, Kiani A.

Haematologica. 2011 Nov;96(11):1580-8. doi: 10.3324/haematol.2011.042515. Epub 2011 Jul 12.


Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis.

Gutiérrez L, Tsukamoto S, Suzuki M, Yamamoto-Mukai H, Yamamoto M, Philipsen S, Ohneda K.

Blood. 2008 Apr 15;111(8):4375-85. doi: 10.1182/blood-2007-09-115121. Epub 2008 Feb 7.

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