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Results: 1 to 20 of 98

1.

Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model.

Parthsarathy V, Hölscher C.

PLoS One. 2013;8(3):e58784. doi: 10.1371/journal.pone.0058784. Epub 2013 Mar 11.

PMID:
23536825
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease.

McClean PL, Hölscher C.

Neuropharmacology. 2014 Jan;76 Pt A:57-67. doi: 10.1016/j.neuropharm.2013.08.005. Epub 2013 Aug 21.

PMID:
23973293
[PubMed - indexed for MEDLINE]
3.

Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain.

Hamilton A, Patterson S, Porter D, Gault VA, Holscher C.

J Neurosci Res. 2011 Apr;89(4):481-9. doi: 10.1002/jnr.22565. Epub 2011 Jan 10.

PMID:
21312223
[PubMed - indexed for MEDLINE]
4.

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

McClean PL, Parthsarathy V, Faivre E, Hölscher C.

J Neurosci. 2011 Apr 27;31(17):6587-94. doi: 10.1523/JNEUROSCI.0529-11.2011.

PMID:
21525299
[PubMed - indexed for MEDLINE]
Free Article
5.

Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis.

Hunter K, Hölscher C.

BMC Neurosci. 2012 Mar 23;13:33. doi: 10.1186/1471-2202-13-33.

PMID:
22443187
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease.

Hamilton A, Holscher C.

Brain Res. 2012 Apr 17;1449:83-93. doi: 10.1016/j.brainres.2012.02.015. Epub 2012 Feb 13.

PMID:
22418058
[PubMed - indexed for MEDLINE]
7.

Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model.

Yu Y, He J, Zhang Y, Luo H, Zhu S, Yang Y, Zhao T, Wu J, Huang Y, Kong J, Tan Q, Li XM.

Hippocampus. 2009 Dec;19(12):1247-53. doi: 10.1002/hipo.20587.

PMID:
19309037
[PubMed - indexed for MEDLINE]
8.

The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease.

Long-Smith CM, Manning S, McClean PL, Coakley MF, O'Halloran DJ, Holscher C, O'Neill C.

Neuromolecular Med. 2013 Mar;15(1):102-14. doi: 10.1007/s12017-012-8199-5. Epub 2012 Sep 21.

PMID:
23011726
[PubMed - indexed for MEDLINE]
9.

Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain.

McGovern SF, Hunter K, Hölscher C.

Brain Res. 2012 Sep 14;1473:204-13. doi: 10.1016/j.brainres.2012.07.029. Epub 2012 Jul 31.

PMID:
22867941
[PubMed - indexed for MEDLINE]
10.

Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress.

Sharma MK, Jalewa J, Hölscher C.

J Neurochem. 2014 Feb;128(3):459-71. doi: 10.1111/jnc.12469. Epub 2013 Oct 28.

PMID:
24112036
[PubMed - indexed for MEDLINE]
11.

Intranasal delivery of plasma and platelet growth factors using PRGF-Endoret system enhances neurogenesis in a mouse model of Alzheimer's disease.

Anitua E, Pascual C, Pérez-Gonzalez R, Antequera D, Padilla S, Orive G, Carro E.

PLoS One. 2013 Sep 19;8(9):e73118. doi: 10.1371/journal.pone.0073118. eCollection 2013.

PMID:
24069173
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's disease.

Rockenstein E, Mante M, Adame A, Crews L, Moessler H, Masliah E.

Acta Neuropathol. 2007 Mar;113(3):265-75. Epub 2006 Nov 28.

PMID:
17131129
[PubMed - indexed for MEDLINE]
13.

Neurogenic effects of β-amyloid in the choroid plexus epithelial cells in Alzheimer's disease.

Bolos M, Spuch C, Ordoñez-Gutierrez L, Wandosell F, Ferrer I, Carro E.

Cell Mol Life Sci. 2013 Aug;70(15):2787-97. doi: 10.1007/s00018-013-1300-x. Epub 2013 Mar 3.

PMID:
23455075
[PubMed - indexed for MEDLINE]
14.

A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury.

Sompol P, Ittarat W, Tangpong J, Chen Y, Doubinskaia I, Batinic-Haberle I, Abdul HM, Butterfield DA, St Clair DK.

Neuroscience. 2008 Apr 22;153(1):120-30. doi: 10.1016/j.neuroscience.2008.01.044. Epub 2008 Feb 7.

PMID:
18353561
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease.

Duffy AM, Hölscher C.

Neuroscience. 2013 Jan 3;228:294-300. doi: 10.1016/j.neuroscience.2012.10.045. Epub 2012 Oct 26.

PMID:
23103794
[PubMed - indexed for MEDLINE]
16.

Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy.

Hattiangady B, Shetty AK.

Hippocampus. 2010 Jan;20(1):97-112. doi: 10.1002/hipo.20594.

PMID:
19309040
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Differential cell proliferation in the cortex of the APPswePS1dE9 Alzheimer's disease mouse model.

Kamphuis W, Orre M, Kooijman L, Dahmen M, Hol EM.

Glia. 2012 Apr;60(4):615-29. doi: 10.1002/glia.22295. Epub 2012 Jan 19.

PMID:
22262260
[PubMed - indexed for MEDLINE]
18.

Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease.

Donovan MH, Yazdani U, Norris RD, Games D, German DC, Eisch AJ.

J Comp Neurol. 2006 Mar 1;495(1):70-83.

PMID:
16432899
[PubMed - indexed for MEDLINE]
19.

Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease.

Holscher C.

Recent Pat CNS Drug Discov. 2010 Jun;5(2):109-17. Review.

PMID:
20337586
[PubMed - indexed for MEDLINE]
20.

The Alzheimer's disease drug memantine increases the number of radial glia-like progenitor cells in adult hippocampus.

Namba T, Maekawa M, Yuasa S, Kohsaka S, Uchino S.

Glia. 2009 Aug 1;57(10):1082-90. doi: 10.1002/glia.20831.

PMID:
19115386
[PubMed - indexed for MEDLINE]

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