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Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.

Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T.

Cell. 2013 Feb 28;152(5):1008-20. doi: 10.1016/j.cell.2013.01.056.


Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine nucleotide exchange factor Sos1.

McDonald CB, Seldeen KL, Deegan BJ, Farooq A.

Arch Biochem Biophys. 2008 Nov 1;479(1):52-62. doi: 10.1016/ Epub 2008 Aug 26.


Quantifying intramolecular binding in multivalent interactions: a structure-based synergistic study on Grb2-Sos1 complex.

Sethi A, Goldstein B, Gnanakaran S.

PLoS Comput Biol. 2011 Oct;7(10):e1002192. doi: 10.1371/journal.pcbi.1002192. Epub 2011 Oct 13.


SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner.

McDonald CB, Seldeen KL, Deegan BJ, Farooq A.

Biochemistry. 2009 May 19;48(19):4074-85. doi: 10.1021/bi802291y.


Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control.

McDonald CB, Seldeen KL, Deegan BJ, Bhat V, Farooq A.

Arch Biochem Biophys. 2010 Feb 15;494(2):216-25. doi: 10.1016/ Epub 2009 Dec 22.


Quantitative analysis of Grb2-Sos1 interaction: the N-terminal SH3 domain of Grb2 mediates affinity.

Sastry L, Lin W, Wong WT, Di Fiore PP, Scoppa CA, King CR.

Oncogene. 1995 Sep 21;11(6):1107-12.


Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.

McDonald CB, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

Biochemistry. 2012 Mar 13;51(10):2122-35. doi: 10.1021/bi3000534. Epub 2012 Mar 2.


The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain.

Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS.

EMBO J. 2000 Mar 15;19(6):1263-71.


SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.

Qu Y, Chen Q, Lai X, Zhu C, Chen C, Zhao X, Deng R, Xu M, Yuan H, Wang Y, Yu J, Huang J.

Mol Cancer. 2014 Apr 29;13:95. doi: 10.1186/1476-4598-13-95.


Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D.

Science. 1993 May 28;260(5112):1338-43.


Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells.

Lioubin MN, Myles GM, Carlberg K, Bowtell D, Rohrschneider LR.

Mol Cell Biol. 1994 Sep;14(9):5682-91.


Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

Cheng AM, Saxton TM, Sakai R, Kulkarni S, Mbamalu G, Vogel W, Tortorice CG, Cardiff RD, Cross JC, Muller WJ, Pawson T.

Cell. 1998 Dec 11;95(6):793-803.


The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.

Zarich N, Oliva JL, Jorge R, Santos E, Rojas JM.

Oncogene. 2000 Nov 30;19(51):5872-83.


Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.

McDonald CB, El Hokayem J, Zafar N, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

J Mol Recognit. 2013 Feb;26(2):92-103. doi: 10.1002/jmr.2256.


Sos-mediated activation of rac1 by p66shc.

Khanday FA, Santhanam L, Kasuno K, Yamamori T, Naqvi A, Dericco J, Bugayenko A, Mattagajasingh I, Disanza A, Scita G, Irani K.

J Cell Biol. 2006 Mar 13;172(6):817-22. Epub 2006 Mar 6.


Differential interactions of human Sos1 and Sos2 with Grb2.

Yang SS, Van Aelst L, Bar-Sagi D.

J Biol Chem. 1995 Aug 4;270(31):18212-5.


Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms.

Ozaki K, Miyazaki S, Tanimura S, Kohno M.

J Cell Sci. 2005 Dec 15;118(Pt 24):5861-71.


Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells.

Ogata A, Chauhan D, Urashima M, Teoh G, Treon SP, Anderson KC.

Clin Cancer Res. 1997 Jun;3(6):1017-22.


Functional coupling of the mammalian EGF receptor to the Ras/cAMP pathway in the yeast Saccharomyces cerevisiae.

Busti S, Sacco E, Martegani E, Vanoni M.

Curr Genet. 2008 Mar;53(3):153-62. doi: 10.1007/s00294-007-0173-7. Epub 2008 Jan 9.


Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2.

Corbalan-Garcia S, Yang SS, Degenhardt KR, Bar-Sagi D.

Mol Cell Biol. 1996 Oct;16(10):5674-82.

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