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Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma.

Mukherjee J, Phillips JJ, Zheng S, Wiencke J, Ronen SM, Pieper RO.

PLoS One. 2013;8(2):e57610. doi: 10.1371/journal.pone.0057610. Epub 2013 Feb 25.


Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis.

Zhan C, Yan L, Wang L, Ma J, Jiang W, Zhang Y, Shi Y, Wang Q.

PLoS One. 2015 Mar 4;10(3):e0118663. doi: 10.1371/journal.pone.0118663. eCollection 2015.


Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.

Chiavarina B, Whitaker-Menezes D, Martinez-Outschoorn UE, Witkiewicz AK, Birbe R, Howell A, Pestell RG, Smith J, Daniel R, Sotgia F, Lisanti MP.

Cancer Biol Ther. 2011 Dec 15;12(12):1101-13. doi: 10.4161/cbt.12.12.18703. Epub 2011 Dec 15.


Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells.

Kefas B, Comeau L, Erdle N, Montgomery E, Amos S, Purow B.

Neuro Oncol. 2010 Nov;12(11):1102-12. doi: 10.1093/neuonc/noq080. Epub 2010 Jul 28.


Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers.

Desai S, Ding M, Wang B, Lu Z, Zhao Q, Shaw K, Yung WK, Weinstein JN, Tan M, Yao J.

Oncotarget. 2014 Sep 30;5(18):8202-10.


No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis.

Bluemlein K, Grüning NM, Feichtinger RG, Lehrach H, Kofler B, Ralser M.

Oncotarget. 2011 May;2(5):393-400.


Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling.

Yang P, Li Z, Fu R, Wu H, Li Z.

Cell Signal. 2014 Sep;26(9):1853-62. doi: 10.1016/j.cellsig.2014.03.020. Epub 2014 Mar 29.


Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):6904-9. doi: 10.1073/pnas.1204176109. Epub 2012 Apr 16.


Overexpression of alpha4 chain-containing laminins in human glial tumors identified by gene microarray analysis.

Ljubimova JY, Lakhter AJ, Loksh A, Yong WH, Riedinger MS, Miner JH, Sorokin LM, Ljubimov AV, Black KL.

Cancer Res. 2001 Jul 15;61(14):5601-10.


PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG.

Cell. 2013 Oct 10;155(2):397-409. doi: 10.1016/j.cell.2013.09.025.


Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis.

Bluemlein K, Glückmann M, Grüning NM, Feichtinger R, Krüger A, Wamelink M, Lehrach H, Tate S, Neureiter D, Kofler B, Ralser M.

Oncotarget. 2012 Nov;3(11):1356-69.


Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.

Gao X, Wang H, Yang JJ, Liu X, Liu ZR.

Mol Cell. 2012 Mar 9;45(5):598-609. doi: 10.1016/j.molcel.2012.01.001. Epub 2012 Feb 2.


Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms.

Taniguchi K, Ito Y, Sugito N, Kumazaki M, Shinohara H, Yamada N, Nakagawa Y, Sugiyama T, Futamura M, Otsuki Y, Yoshida K, Uchiyama K, Akao Y.

Sci Rep. 2015 Feb 27;5:8647. doi: 10.1038/srep08647.


Identification of small molecule inhibitors of pyruvate kinase M2.

Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC.

Biochem Pharmacol. 2010 Apr 15;79(8):1118-24. doi: 10.1016/j.bcp.2009.12.003. Epub 2009 Dec 11.


Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells.

Zhou CF, Li XB, Sun H, Zhang B, Han YS, Jiang Y, Zhuang QL, Fang J, Wu GH.

IUBMB Life. 2012 Sep;64(9):775-82. doi: 10.1002/iub.1066. Epub 2012 Jul 18.


Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.

Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO.

Cancer Res. 2014 Dec 1;74(23):7115-24. doi: 10.1158/0008-5472.CAN-14-0849. Epub 2014 Oct 15.


M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.

Cortés-Cros M, Hemmerlin C, Ferretti S, Zhang J, Gounarides JS, Yin H, Muller A, Haberkorn A, Chene P, Sellers WR, Hofmann F.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):489-94. doi: 10.1073/pnas.1212780110. Epub 2012 Dec 24.


Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2.

Iqbal MA, Siddiqui FA, Gupta V, Chattopadhyay S, Gopinath P, Kumar B, Manvati S, Chaman N, Bamezai RN.

Mol Cancer. 2013 Jul 9;12:72. doi: 10.1186/1476-4598-12-72.


Control of glioma cell death and differentiation by PKM2-Oct4 interaction.

Morfouace M, Lalier L, Oliver L, Cheray M, Pecqueur C, Cartron PF, Vallette FM.

Cell Death Dis. 2014 Jan 30;5:e1036. doi: 10.1038/cddis.2013.561.


ERK2-Pyruvate Kinase Axis Permits Phorbol 12-Myristate 13-Acetate-induced Megakaryocyte Differentiation in K562 Cells.

Chaman N, Iqbal MA, Siddiqui FA, Gopinath P, Bamezai RN.

J Biol Chem. 2015 Sep 25;290(39):23803-15. doi: 10.1074/jbc.M115.657411. Epub 2015 Aug 12.

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