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Results: 1 to 20 of 97

1.

Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond.

Jiang W, Cashman JR, Nachon F, Masson P, Schopfer LM, Lockridge O.

Toxicol Sci. 2013 Apr;132(2):390-8. doi: 10.1093/toxsci/kft011. Epub 2013 Jan 23.

PMID:
23345579
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.

Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O.

Chem Res Toxicol. 2009 Oct;22(10):1680-8. doi: 10.1021/tx900090m.

PMID:
19715348
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase.

Jiang W, Murashko EA, Dubrovskii YA, Podolskaya EP, Babakov VN, Mikler J, Nachon F, Masson P, Schopfer LM, Lockridge O.

Anal Biochem. 2013 Aug 15;439(2):132-41. doi: 10.1016/j.ab.2013.04.018. Epub 2013 Apr 25.

PMID:
23624322
[PubMed - indexed for MEDLINE]
4.

Structural approach to the aging of phosphylated cholinesterases.

Masson P, Nachon F, Lockridge O.

Chem Biol Interact. 2010 Sep 6;187(1-3):157-62. doi: 10.1016/j.cbi.2010.03.027. Epub 2010 Mar 23. Review.

PMID:
20338153
[PubMed - indexed for MEDLINE]
5.

Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.

Li H, Schopfer LM, Nachon F, Froment MT, Masson P, Lockridge O.

Toxicol Sci. 2007 Nov;100(1):136-45. Epub 2007 Aug 13.

PMID:
17698511
[PubMed - indexed for MEDLINE]
Free Article
6.

Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.

Carletti E, Aurbek N, Gillon E, Loiodice M, Nicolet Y, Fontecilla-Camps JC, Masson P, Thiermann H, Nachon F, Worek F.

Biochem J. 2009 Jun 12;421(1):97-106. doi: 10.1042/BJ20090091.

PMID:
19368529
[PubMed - indexed for MEDLINE]
Free Article
7.

Identification of butyrylcholinesterase adducts after inhibition with isomalathion using mass spectrometry: difference in mechanism between (1R)- and (1S)-stereoisomers.

Doorn JA, Schall M, Gage DA, Talley TT, Thompson CM, Richardson RJ.

Toxicol Appl Pharmacol. 2001 Oct 15;176(2):73-80.

PMID:
11601883
[PubMed - indexed for MEDLINE]
8.

Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation.

Carletti E, Li H, Li B, Ekström F, Nicolet Y, Loiodice M, Gillon E, Froment MT, Lockridge O, Schopfer LM, Masson P, Nachon F.

J Am Chem Soc. 2008 Nov 26;130(47):16011-20. doi: 10.1021/ja804941z.

PMID:
18975951
[PubMed - indexed for MEDLINE]
9.

Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: MALDI-TOF/MS analysis of various nerve agent phosphyl adducts.

Elhanany E, Ordentlich A, Dgany O, Kaplan D, Segall Y, Barak R, Velan B, Shafferman A.

Chem Res Toxicol. 2001 Jul;14(7):912-8.

PMID:
11453739
[PubMed - indexed for MEDLINE]
10.

Direct quantitation of methyl phosphonate adducts to human serum butyrylcholinesterase by immunomagnetic-UHPLC-MS/MS.

Carter MD, Crow BS, Pantazides BG, Watson CM, Thomas JD, Blake TA, Johnson RC.

Anal Chem. 2013 Nov 19;85(22):11106-11. doi: 10.1021/ac4029714. Epub 2013 Nov 8.

PMID:
24205842
[PubMed - indexed for MEDLINE]
11.

Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.

Carletti E, Colletier JP, Dupeux F, Trovaslet M, Masson P, Nachon F.

J Med Chem. 2010 May 27;53(10):4002-8. doi: 10.1021/jm901853b.

PMID:
20408548
[PubMed - indexed for MEDLINE]
12.

Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging.

Nachon F, Asojo OA, Borgstahl GE, Masson P, Lockridge O.

Biochemistry. 2005 Feb 1;44(4):1154-62.

PMID:
15667209
[PubMed - indexed for MEDLINE]
13.

Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase.

Barak D, Ordentlich A, Kaplan D, Barak R, Mizrahi D, Kronman C, Segall Y, Velan B, Shafferman A.

Biochemistry. 2000 Feb 8;39(5):1156-61.

PMID:
10653663
[PubMed - indexed for MEDLINE]
14.

Mechanism of aging of mipafox-inhibited butyrylcholinesterase.

Kropp TJ, Richardson RJ.

Chem Res Toxicol. 2007 Mar;20(3):504-10. Epub 2007 Feb 27.

PMID:
17323978
[PubMed - indexed for MEDLINE]
15.

The pH dependence of dealkylation in soman-inhibited cholinesterases and their mutants: further evidence for a push-pull mechanism.

Saxena A, Viragh C, Frazier DS, Kovach IM, Maxwell DM, Lockridge O, Doctor BP.

Biochemistry. 1998 Oct 27;37(43):15086-96.

PMID:
9790671
[PubMed - indexed for MEDLINE]
16.

Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis.

Carletti E, Schopfer LM, Colletier JP, Froment MT, Nachon F, Weik M, Lockridge O, Masson P.

Chem Res Toxicol. 2011 Jun 20;24(6):797-808. doi: 10.1021/tx100447k. Epub 2011 Apr 18.

PMID:
21438623
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase.

Liyasova MS, Schopfer LM, Lockridge O.

Chem Biol Interact. 2013 Mar 25;203(1):103-7. doi: 10.1016/j.cbi.2012.07.006. Epub 2012 Aug 8.

PMID:
22898212
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry.

Tacal O, Lockridge O.

J Appl Toxicol. 2010 Jul;30(5):469-75. doi: 10.1002/jat.1518.

PMID:
20229498
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum.

Li H, Ricordel I, Tong L, Schopfer LM, Baud F, Mégarbane B, Maury E, Masson P, Lockridge O.

J Appl Toxicol. 2009 Mar;29(2):149-55. doi: 10.1002/jat.1392.

PMID:
18937214
[PubMed - indexed for MEDLINE]
20.

Kinetics and mechanism of inhibition of serine esterases by fluorinated aminophosphonates.

Makhaeva GF, Aksinenko AY, Sokolov VB, Baskin II, Palyulin VA, Zefirov NS, Hein ND, Kampf JW, Wijeyesakere SJ, Richardson RJ.

Chem Biol Interact. 2010 Sep 6;187(1-3):177-84. doi: 10.1016/j.cbi.2009.12.018. Epub 2009 Dec 23.

PMID:
20035729
[PubMed - indexed for MEDLINE]

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