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Items: 1 to 20 of 144

1.

The receptors that mediate the direct lethality of anthrax toxin.

Liu S, Zhang Y, Hoover B, Leppla SH.

Toxins (Basel). 2012 Dec 27;5(1):1-8. doi: 10.3390/toxins5010001.

2.

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo.

Liu S, Crown D, Miller-Randolph S, Moayeri M, Wang H, Hu H, Morley T, Leppla SH.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12424-9. doi: 10.1073/pnas.0905409106. Epub 2009 Jul 15.

3.

Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin.

Martchenko M, Jeong SY, Cohen SN.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15583-8. doi: 10.1073/pnas.1010145107. Epub 2010 Aug 16.

4.

Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor.

Scobie HM, Rainey GJ, Bradley KA, Young JA.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4. Epub 2003 Apr 16.

5.

Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells.

Chen KH, Liu S, Bankston LA, Liddington RC, Leppla SH.

J Biol Chem. 2007 Mar 30;282(13):9834-45. Epub 2007 Jan 24.

6.

Anthrax edema toxin impairs clearance in mice.

Sastalla I, Tang S, Crown D, Liu S, Eckhaus MA, Hewlett IK, Leppla SH, Moayeri M.

Infect Immun. 2012 Feb;80(2):529-38. doi: 10.1128/IAI.05947-11. Epub 2011 Nov 21.

7.

Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice.

Liu S, Miller-Randolph S, Crown D, Moayeri M, Sastalla I, Okugawa S, Leppla SH.

Cell Host Microbe. 2010 Nov 18;8(5):455-62. doi: 10.1016/j.chom.2010.10.004.

8.

Targeted silencing of anthrax toxin receptors protects against anthrax toxins.

Arévalo MT, Navarro A, Arico CD, Li J, Alkhatib O, Chen S, Diaz-Arévalo D, Zeng M.

J Biol Chem. 2014 May 30;289(22):15730-8. doi: 10.1074/jbc.M113.538587. Epub 2014 Apr 17.

9.

The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin.

Fu S, Tong X, Cai C, Zhao Y, Wu Y, Li Y, Xu J, Zhang XC, Xu L, Chen W, Rao Z.

PLoS One. 2010 Jun 18;5(6):e11203. doi: 10.1371/journal.pone.0011203.

10.

Receptor-specific requirements for anthrax toxin delivery into cells.

Rainey GJ, Wigelsworth DJ, Ryan PL, Scobie HM, Collier RJ, Young JA.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13278-83. Epub 2005 Sep 1.

11.

Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen.

Wigelsworth DJ, Krantz BA, Christensen KA, Lacy DB, Juris SJ, Collier RJ.

J Biol Chem. 2004 May 28;279(22):23349-56. Epub 2004 Mar 24.

12.

Tumor endothelium marker-8 based decoys exhibit superiority over capillary morphogenesis protein-2 based decoys as anthrax toxin inhibitors.

Cai C, Che J, Xu L, Guo Q, Kong Y, Fu L, Xu J, Cheng Y, Chen W.

PLoS One. 2011;6(6):e20646. doi: 10.1371/journal.pone.0020646. Epub 2011 Jun 2.

13.

Interactions between anthrax toxin receptors and protective antigen.

Scobie HM, Young JA.

Curr Opin Microbiol. 2005 Feb;8(1):106-12. Review.

PMID:
15694864
14.

Anthrax lethal and edema toxins in anthrax pathogenesis.

Liu S, Moayeri M, Leppla SH.

Trends Microbiol. 2014 Jun;22(6):317-25. doi: 10.1016/j.tim.2014.02.012. Epub 2014 Mar 27. Review.

15.

Anthrax toxin uptake by primary immune cells as determined with a lethal factor-beta-lactamase fusion protein.

Hu H, Leppla SH.

PLoS One. 2009 Nov 23;4(11):e7946. doi: 10.1371/journal.pone.0007946.

16.

Anthrax toxin receptor 2-dependent lethal toxin killing in vivo.

Scobie HM, Wigelsworth DJ, Marlett JM, Thomas D, Rainey GJ, Lacy DB, Manchester M, Collier RJ, Young JA.

PLoS Pathog. 2006 Oct;2(10):e111. Erratum in: PLoS Pathog. 2008 Oct;4(10).doi:10.1371/annotation/08c1bcf0-da65-4abd-97c7-5df86b1120b5.

17.

Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.

Jeong SY, Martchenko M, Cohen SN.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4007-15. doi: 10.1073/pnas.1316852110. Epub 2013 Oct 1.

18.

Key tissue targets responsible for anthrax-toxin-induced lethality.

Liu S, Zhang Y, Moayeri M, Liu J, Crown D, Fattah RJ, Wein AN, Yu ZX, Finkel T, Leppla SH.

Nature. 2013 Sep 5;501(7465):63-8. doi: 10.1038/nature12510. Epub 2013 Aug 28.

19.

Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli.

Ding Z, Bradley KA, Amin Arnaout M, Xiong JP.

Protein Expr Purif. 2006 Sep;49(1):121-8. Epub 2006 Apr 28.

PMID:
16798009
20.

Anthrax Toxin Protective Antigen Variants that selectively utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting.

Chen KH, Liu S, Leysath CE, Miller-Randolph S, Zhang Y, Fattah R, Bugge TH, Leppla SH.

J Biol Chem. 2016 Aug 23. pii: jbc.M116.753301. [Epub ahead of print]

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