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In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice.

Palmer BE, Neff CP, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman AJ, Fontenot AP, Akkina R.

J Immunol. 2013 Jan 1;190(1):211-9. doi: 10.4049/jimmunol.1201108. Epub 2012 Dec 3.


PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads.

Seung E, Dudek TE, Allen TM, Freeman GJ, Luster AD, Tager AM.

PLoS One. 2013 Oct 21;8(10):e77780. doi: 10.1371/journal.pone.0077780. eCollection 2013.


PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.

Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C, Mncube Z, Duraiswamy J, Zhu B, Eichbaum Q, Altfeld M, Wherry EJ, Coovadia HM, Goulder PJ, Klenerman P, Ahmed R, Freeman GJ, Walker BD.

Nature. 2006 Sep 21;443(7109):350-4. Epub 2006 Aug 20.


Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction.

D'Souza M, Fontenot AP, Mack DG, Lozupone C, Dillon S, Meditz A, Wilson CC, Connick E, Palmer BE.

J Immunol. 2007 Aug 1;179(3):1979-87.


HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model.

Berges BK, Wheat WH, Palmer BE, Connick E, Akkina R.

Retrovirology. 2006 Nov 1;3:76.


Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions.

Porichis F, Hart MG, Zupkosky J, Barblu L, Kwon DS, McMullen A, Brennan T, Ahmed R, Freeman GJ, Kavanagh DG, Kaufmann DE.

J Virol. 2014 Mar;88(5):2508-18. doi: 10.1128/JVI.02034-13. Epub 2013 Dec 18.


Combined Env- and Gag-specific T cell responses in relation to programmed death-1 receptor and CD4 T cell loss rates in human immunodeficiency virus-1 infection.

Pettersen FO, Taskén K, Kvale D.

Clin Exp Immunol. 2010 Aug;161(2):315-23. doi: 10.1111/j.1365-2249.2010.04179.x. Epub 2010 May 10.


Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.

Ito T, Ueno T, Clarkson MR, Yuan X, Jurewicz MM, Yagita H, Azuma M, Sharpe AH, Auchincloss H Jr, Sayegh MH, Najafian N.

J Immunol. 2005 Jun 1;174(11):6648-56.


Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year.

Berges BK, Akkina SR, Remling L, Akkina R.

Virology. 2010 Feb 5;397(1):100-3. doi: 10.1016/j.virol.2009.10.034. Epub 2009 Nov 18.


Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.

Brainard DM, Seung E, Frahm N, Cariappa A, Bailey CC, Hart WK, Shin HS, Brooks SF, Knight HL, Eichbaum Q, Yang YG, Sykes M, Walker BD, Freeman GJ, Pillai S, Westmoreland SV, Brander C, Luster AD, Tager AM.

J Virol. 2009 Jul;83(14):7305-21. doi: 10.1128/JVI.02207-08. Epub 2009 May 6.


Human immunodeficiency virus (HIV-1) infection selectively downregulates PD-1 expression in infected cells and protects the cells from early apoptosis in vitro and in vivo.

Venkatachari NJ, Buchanan WG, Ayyavoo V.

Virology. 2008 Jun 20;376(1):140-53. doi: 10.1016/j.virol.2008.03.015. Epub 2008 Apr 25.


PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model.

Tzeng HT, Tsai HF, Liao HJ, Lin YJ, Chen L, Chen PJ, Hsu PN.

PLoS One. 2012;7(6):e39179. doi: 10.1371/journal.pone.0039179. Epub 2012 Jun 22.


Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice.

Zhou J, Neff CP, Liu X, Zhang J, Li H, Smith DD, Swiderski P, Aboellail T, Huang Y, Du Q, Liang Z, Peng L, Akkina R, Rossi JJ.

Mol Ther. 2011 Dec;19(12):2228-38. doi: 10.1038/mt.2011.207. Epub 2011 Sep 27.


Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.

Kearl TJ, Jing W, Gershan JA, Johnson BD.

J Immunol. 2013 Jun 1;190(11):5620-8. doi: 10.4049/jimmunol.1202005. Epub 2013 Apr 24.


Programmed death (PD)-1 molecule and its ligand PD-L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus-1-infected individuals.

Rosignoli G, Lim CH, Bower M, Gotch F, Imami N.

Clin Exp Immunol. 2009 Jul;157(1):90-7. doi: 10.1111/j.1365-2249.2009.03960.x.


Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection.

Kassu A, Marcus RA, D'Souza MB, Kelly-McKnight EA, Golden-Mason L, Akkina R, Fontenot AP, Wilson CC, Palmer BE.

J Immunol. 2010 Sep 1;185(5):3007-18. doi: 10.4049/jimmunol.1000156. Epub 2010 Jul 23.


Programmed death 1 receptor changes ex vivo in HIV-infected adults following initiation of highly active antiretroviral therapy.

Spitsin S, Tustin NB, Riedel E, Tustin R 3rd, Murray JB, Peck LM, Khan M, Quinn J, Douglas SD.

Clin Vaccine Immunol. 2012 May;19(5):752-6. doi: 10.1128/CVI.00093-12. Epub 2012 Mar 21.


PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia.

Tendeiro R, Foxall RB, Baptista AP, Pinto F, Soares RS, Cavaleiro R, Valadas E, Gomes P, Victorino RM, Sousa AE.

AIDS. 2012 Jun 1;26(9):1065-71. doi: 10.1097/QAD.0b013e32835374db.


B cell responses to HIV antigen are a potent correlate of viremia in HIV-1 infection and improve with PD-1 blockade.

Nicholas KJ, Zern EK, Barnett L, Smith RM, Lorey SL, Copeland CA, Sadagopal S, Kalams SA.

PLoS One. 2013 Dec 16;8(12):e84185. doi: 10.1371/journal.pone.0084185. eCollection 2013.


Latent HIV-1 infection of resting CD4⁺ T cells in the humanized Rag2⁻/⁻ γc⁻/⁻ mouse.

Choudhary SK, Archin NM, Cheema M, Dahl NP, Garcia JV, Margolis DM.

J Virol. 2012 Jan;86(1):114-20. doi: 10.1128/JVI.05590-11. Epub 2011 Oct 19.

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