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Results: 1 to 20 of 166

1.

DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9.

Ohouo PY, Bastos de Oliveira FM, Liu Y, Ma CJ, Smolka MB.

Nature. 2013 Jan 3;493(7430):120-4. doi: 10.1038/nature11658. Epub 2012 Nov 18.

PMID:
23160493
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response.

Ohouo PY, Bastos de Oliveira FM, Almeida BS, Smolka MB.

Mol Cell. 2010 Jul 30;39(2):300-6. doi: 10.1016/j.molcel.2010.06.019.

PMID:
20670896
[PubMed - indexed for MEDLINE]
Free Article
3.

Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4.

Roberts TM, Kobor MS, Bastin-Shanower SA, Ii M, Horte SA, Gin JW, Emili A, Rine J, Brill SJ, Brown GW.

Mol Biol Cell. 2006 Jan;17(1):539-48. Epub 2005 Nov 2.

PMID:
16267268
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway.

Lévesque N, Leung GP, Fok AK, Schmidt TI, Kobor MS.

J Biol Chem. 2010 Nov 5;285(45):35113-22. doi: 10.1074/jbc.M110.116855. Epub 2010 Sep 1.

PMID:
20810656
[PubMed - indexed for MEDLINE]
Free PMC Article
5.
6.

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

Hoch NC, Chen ES, Buckland R, Wang SC, Fazio A, Hammet A, Pellicioli A, Chabes A, Tsai MD, Heierhorst J.

Mol Cell Biol. 2013 Aug;33(16):3202-13. doi: 10.1128/MCB.00474-13. Epub 2013 Jun 10.

PMID:
23754745
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.

Sweeney FD, Yang F, Chi A, Shabanowitz J, Hunt DF, Durocher D.

Curr Biol. 2005 Aug 9;15(15):1364-75.

PMID:
16085488
[PubMed - indexed for MEDLINE]
Free Article
8.

CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.

Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP.

PLoS Biol. 2010 Jan 26;8(1):e1000286. doi: 10.1371/journal.pbio.1000286.

PMID:
20126259
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.

Vialard JE, Gilbert CS, Green CM, Lowndes NF.

EMBO J. 1998 Oct 1;17(19):5679-88.

PMID:
9755168
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast.

Gangavarapu V, Santa Maria SR, Prakash S, Prakash L.

MBio. 2011 May 17;2(3):e00079-11. doi: 10.1128/mBio.00079-11. Print 2011.

PMID:
21586645
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

Duch A, Felipe-Abrio I, Barroso S, Yaakov G, García-Rubio M, Aguilera A, de Nadal E, Posas F.

Nature. 2013 Jan 3;493(7430):116-9. doi: 10.1038/nature11675. Epub 2012 Nov 25.

PMID:
23178807
[PubMed - indexed for MEDLINE]
12.

Association of Rad9 with double-strand breaks through a Mec1-dependent mechanism.

Naiki T, Wakayama T, Nakada D, Matsumoto K, Sugimoto K.

Mol Cell Biol. 2004 Apr;24(8):3277-85.

PMID:
15060150
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε.

Puddu F, Piergiovanni G, Plevani P, Muzi-Falconi M.

PLoS Genet. 2011 Mar;7(3):e1002022. doi: 10.1371/journal.pgen.1002022. Epub 2011 Mar 17.

PMID:
21436894
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage.

O'Neill BM, Szyjka SJ, Lis ET, Bailey AO, Yates JR 3rd, Aparicio OM, Romesberg FE.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9290-5. Epub 2007 May 21.

PMID:
17517611
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.

Clerici M, Baldo V, Mantiero D, Lottersberger F, Lucchini G, Longhese MP.

Mol Cell Biol. 2004 Dec;24(23):10126-44.

PMID:
15542824
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress.

Feng W, Bachant J, Collingwood D, Raghuraman MK, Brewer BJ.

Genetics. 2009 Dec;183(4):1249-60. doi: 10.1534/genetics.109.107508. Epub 2009 Oct 5.

PMID:
19805819
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase.

Navadgi-Patil VM, Burgers PM.

J Biol Chem. 2008 Dec 19;283(51):35853-9. doi: 10.1074/jbc.M807435200. Epub 2008 Oct 15.

PMID:
18922789
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Regulation of tolerance to DNA alkylating damage by Dot1 and Rad53 in Saccharomyces cerevisiae.

Conde F, Ontoso D, Acosta I, Gallego-Sánchez A, Bueno A, San-Segundo PA.

DNA Repair (Amst). 2010 Oct 5;9(10):1038-49. doi: 10.1016/j.dnarep.2010.07.003. Epub 2010 Jul 31.

PMID:
20674515
[PubMed - indexed for MEDLINE]
19.

G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint.

Manfrini N, Gobbini E, Baldo V, Trovesi C, Lucchini G, Longhese MP.

Mol Cell Biol. 2012 Dec;32(24):4971-85. doi: 10.1128/MCB.00956-12. Epub 2012 Oct 8.

PMID:
23045388
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.

Javaheri A, Wysocki R, Jobin-Robitaille O, Altaf M, Côté J, Kron SJ.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13771-6. Epub 2006 Aug 29.

PMID:
16940359
[PubMed - indexed for MEDLINE]
Free PMC Article

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