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Items: 1 to 20 of 108

1.

Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.

Kaiser SE, Mao K, Taherbhoy AM, Yu S, Olszewski JL, Duda DM, Kurinov I, Deng A, Fenn TD, Klionsky DJ, Schulman BA.

Nat Struct Mol Biol. 2012 Dec;19(12):1242-9. doi: 10.1038/nsmb.2415. Epub 2012 Nov 11.

2.

Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7.

Yamaguchi M, Matoba K, Sawada R, Fujioka Y, Nakatogawa H, Yamamoto H, Kobashigawa Y, Hoshida H, Akada R, Ohsumi Y, Noda NN, Inagaki F.

Nat Struct Mol Biol. 2012 Dec;19(12):1250-6. doi: 10.1038/nsmb.2451. Epub 2012 Nov 11.

PMID:
23142983
3.

Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.

Taherbhoy AM, Tait SW, Kaiser SE, Williams AH, Deng A, Nourse A, Hammel M, Kurinov I, Rock CO, Green DR, Schulman BA.

Mol Cell. 2011 Nov 4;44(3):451-61. doi: 10.1016/j.molcel.2011.08.034.

4.

Structures of Atg7-Atg3 and Atg7-Atg10 reveal noncanonical mechanisms of E2 recruitment by the autophagy E1.

Kaiser SE, Qiu Y, Coats JE, Mao K, Klionsky DJ, Schulman BA.

Autophagy. 2013 May;9(5):778-80. doi: 10.4161/auto.23644. Epub 2013 Feb 6.

5.

Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3.

Qiu Y, Hofmann K, Coats JE, Schulman BA, Kaiser SE.

Protein Sci. 2013 Dec;22(12):1691-7. doi: 10.1002/pro.2381.

6.

The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation.

Tanida I, Yamasaki M, Komatsu M, Ueno T.

Autophagy. 2012 Jan;8(1):88-97. doi: 10.4161/auto.8.1.18339. Epub 2012 Jan 1.

PMID:
22170151
7.

Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8.

Hong SB, Kim BW, Lee KE, Kim SW, Jeon H, Kim J, Song HK.

Nat Struct Mol Biol. 2011 Nov 6;18(12):1323-30. doi: 10.1038/nsmb.2165.

PMID:
22056771
8.

Structural basis of Atg8 activation by a homodimeric E1, Atg7.

Noda NN, Satoo K, Fujioka Y, Kumeta H, Ogura K, Nakatogawa H, Ohsumi Y, Inagaki F.

Mol Cell. 2011 Nov 4;44(3):462-75. doi: 10.1016/j.molcel.2011.08.035.

9.

Structure of the autophagic E2 enzyme Atg10.

Hong SB, Kim BW, Kim JH, Song HK.

Acta Crystallogr D Biol Crystallogr. 2012 Oct;68(Pt 10):1409-17. Epub 2012 Sep 18.

PMID:
22993095
10.

Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes.

Ohashi K, Otomo T.

Biochem Biophys Res Commun. 2015 Jul 31;463(3):447-52. doi: 10.1016/j.bbrc.2015.05.107. Epub 2015 Jun 2.

PMID:
26043688
11.

The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation.

Yamada Y, Suzuki NN, Hanada T, Ichimura Y, Kumeta H, Fujioka Y, Ohsumi Y, Inagaki F.

J Biol Chem. 2007 Mar 16;282(11):8036-43. Epub 2007 Jan 16.

12.

Uba1 functions in Atg7- and Atg3-independent autophagy.

Chang TK, Shravage BV, Hayes SD, Powers CM, Simin RT, Wade Harper J, Baehrecke EH.

Nat Cell Biol. 2013 Sep;15(9):1067-78. doi: 10.1038/ncb2804. Epub 2013 Jul 21.

13.

Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways.

Wang J, Taherbhoy AM, Hunt HW, Seyedin SN, Miller DW, Miller DJ, Huang DT, Schulman BA.

PLoS One. 2010 Dec 30;5(12):e15805. doi: 10.1371/journal.pone.0015805.

14.

Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.

Lee I, Schindelin H.

Cell. 2008 Jul 25;134(2):268-78. doi: 10.1016/j.cell.2008.05.046.

15.

Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.

Huang DT, Hunt HW, Zhuang M, Ohi MD, Holton JM, Schulman BA.

Nature. 2007 Jan 25;445(7126):394-8. Epub 2007 Jan 14.

16.
17.

Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy.

Nakatogawa H.

Essays Biochem. 2013;55:39-50. doi: 10.1042/bse0550039. Review.

PMID:
24070470
18.

Purification and characterization of a ubiquitin-like system for autophagosome formation.

Bae JY, Park HH.

J Microbiol Biotechnol. 2010 Dec;20(12):1647-52.

19.

Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site.

Sakoh-Nakatogawa M, Matoba K, Asai E, Kirisako H, Ishii J, Noda NN, Inagaki F, Nakatogawa H, Ohsumi Y.

Nat Struct Mol Biol. 2013 Apr;20(4):433-9. doi: 10.1038/nsmb.2527. Epub 2013 Mar 17.

PMID:
23503366
20.

Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.

Bacik JP, Walker JR, Ali M, Schimmer AD, Dhe-Paganon S.

J Biol Chem. 2010 Jun 25;285(26):20273-80. doi: 10.1074/jbc.M110.102921. Epub 2010 Apr 5.

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