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Items: 1 to 20 of 106


CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid.

Cheng J, Krausz KW, Li F, Ma X, Gonzalez FJ.

Toxicol Appl Pharmacol. 2013 Jan 15;266(2):245-53. doi: 10.1016/j.taap.2012.10.024. Epub 2012 Nov 8.


Resistance of SHP-null mice to bile acid-induced liver damage.

Wang L, Han Y, Kim CS, Lee YK, Moore DD.

J Biol Chem. 2003 Nov 7;278(45):44475-81. Epub 2003 Aug 21.


Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice.

Lian Y, Zhao J, Xu P, Wang Y, Zhao J, Jia L, Fu Z, Jing L, Liu G, Peng S.

PLoS One. 2013 Aug 13;8(8):e72058. doi: 10.1371/journal.pone.0072058. eCollection 2013.


Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.

Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AI.

Hepatology. 2008 May;47(5):1483-94. doi: 10.1002/hep.22222.


Selected pharmaceutical excipient prevent isoniazid and rifampicin induced hepatotoxicity.

Shih TY, Ho SC, Hsiong CH, Huang TY, Hu OY.

Curr Drug Metab. 2013 Jul;14(6):720-8.


Effect of chitosan supplementation on antitubercular drugs-induced hepatotoxicity in rats.

Santhosh S, Sini TK, Anandan R, Mathew PT.

Toxicology. 2006 Feb 15;219(1-3):53-9. Epub 2005 Dec 5.


Role of CYP3A in isoniazid metabolism in vivo.

Liu K, Li F, Lu J, Gao Z, Klaassen CD, Ma X.

Drug Metab Pharmacokinet. 2014;29(2):219-22. Epub 2013 Oct 29.


CYP2E1 mediated isoniazid-induced hepatotoxicity in rats.

Yue J, Peng RX, Yang J, Kong R, Liu J.

Acta Pharmacol Sin. 2004 May;25(5):699-704.


Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo.

Wang X, Wu D, Yang L, Gan L, Cederbaum AI.

Free Radic Biol Med. 2013 Oct;63:175-86. doi: 10.1016/j.freeradbiomed.2013.05.009. Epub 2013 May 10.


Inhibition of isoniazid-induced hepatotoxicity in rabbits by pretreatment with an amidase inhibitor.

Sarich TC, Adams SP, Petricca G, Wright JM.

J Pharmacol Exp Ther. 1999 May;289(2):695-702.


CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.

Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ, Keshavarzian A, Song BJ.

Free Radic Biol Med. 2013 Dec;65:1238-45. doi: 10.1016/j.freeradbiomed.2013.09.009. Epub 2013 Sep 21.


Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice.

Cheng J, Fang ZZ, Kim JH, Krausz KW, Tanaka N, Chiang JY, Gonzalez FJ.

J Lipid Res. 2014 Mar;55(3):455-65. doi: 10.1194/jlr.M044420. Epub 2013 Dec 16.


Lipopolysaccharide exposure augments isoniazide-induced liver injury.

Su Y, Zhang Y, Chen M, Jiang Z, Sun L, Wang T, Zhang L.

J Appl Toxicol. 2014 Dec;34(12):1436-42. doi: 10.1002/jat.2979. Epub 2014 Feb 6.


The role of l-thyroxine and hepatic reductase activity in isoniazid-induced hepatotoxicity in rabbits.

Sarich TC, Adams SP, Wright JM.

Pharmacol Res. 1998 Sep;38(3):199-207.


Protective effects of kaempferol on isoniazid- and rifampicin-induced hepatotoxicity.

Shih TY, Young TH, Lee HS, Hsieh CB, Hu OY.

AAPS J. 2013 Jul;15(3):753-62. doi: 10.1208/s12248-013-9490-6. Epub 2013 Apr 17.


Induction of CYP2E1 in testes of isoniazid-treated rats as possible cause of testicular disorders.

Shayakhmetova GM, Bondarenko LB, Voronina AK, Anisimova SI, Matvienko AV, Kovalenko VM.

Toxicol Lett. 2015 Apr 16;234(2):59-66. doi: 10.1016/j.toxlet.2015.02.008. Epub 2015 Feb 13.


Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy.

Wu D, Wang X, Zhou R, Yang L, Cederbaum AI.

Free Radic Biol Med. 2012 Sep 15;53(6):1346-57. doi: 10.1016/j.freeradbiomed.2012.07.005. Epub 2012 Jul 20.


Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity.

Miyata M, Tozawa A, Otsuka H, Nakamura T, Nagata K, Gonzalez FJ, Yamazoe Y.

J Pharmacol Exp Ther. 2005 Feb;312(2):759-66. Epub 2004 Oct 1.


Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.

Aubert J, Begriche K, Delannoy M, Morel I, Pajaud J, Ribault C, Lepage S, McGill MR, Lucas-Clerc C, Turlin B, Robin MA, Jaeschke H, Fromenty B.

J Pharmacol Exp Ther. 2012 Sep;342(3):676-87. doi: 10.1124/jpet.112.193813. Epub 2012 May 30.

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