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Results: 1 to 20 of 105

1.

Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules.

Johnson S, Tan L, van der Veen S, Caesar J, Goicoechea De Jorge E, Harding RJ, Bai X, Exley RM, Ward PN, Ruivo N, Trivedi K, Cumber E, Jones R, Newham L, Staunton D, Ufret-Vincenty R, Borrow R, Pickering MC, Lea SM, Tang CM.

PLoS Pathog. 2012;8(10):e1002981. doi: 10.1371/journal.ppat.1002981. Epub 2012 Oct 25. Erratum in: PLoS Pathog. 2013 Jan;9(1). doi: 10.1371/annotation/3e7e6415-fb12-4a87-89e6-f87d2e800ba8.

PMID:
23133374
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Nonfunctional variant 3 factor H binding proteins as meningococcal vaccine candidates.

van der Veen S, Johnson S, Jongerius I, Malik T, Genovese A, Santini L, Staunton D, Ufret-Vincenty RL, Pickering MC, Lea SM, Tang CM.

Infect Immun. 2014 Mar;82(3):1157-63. doi: 10.1128/IAI.01183-13. Epub 2013 Dec 30.

PMID:
24379280
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Does binding of complement factor H to the meningococcal vaccine antigen, factor H binding protein, decrease protective serum antibody responses?

Granoff DM, Ram S, Beernink PT.

Clin Vaccine Immunol. 2013 Aug;20(8):1099-107. doi: 10.1128/CVI.00260-13. Epub 2013 Jun 5. Review.

PMID:
23740919
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein.

Jongerius I, Lavender H, Tan L, Ruivo N, Exley RM, Caesar JJ, Lea SM, Johnson S, Tang CM.

PLoS Pathog. 2013;9(8):e1003528. doi: 10.1371/journal.ppat.1003528. Epub 2013 Aug 1.

PMID:
23935503
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination.

Beernink PT, Shaughnessy J, Braga EM, Liu Q, Rice PA, Ram S, Granoff DM.

J Immunol. 2011 Mar 15;186(6):3606-14. doi: 10.4049/jimmunol.1003470. Epub 2011 Feb 16.

PMID:
21325619
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein.

Beernink PT, Shaughnessy J, Pajon R, Braga EM, Ram S, Granoff DM.

PLoS Pathog. 2012;8(5):e1002688. doi: 10.1371/journal.ppat.1002688. Epub 2012 May 10.

PMID:
22589720
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Meningococcal factor H binding protein fHbpd184 polymorphism influences clinical course of meningococcal meningitis.

Piet JR, Brouwer MC, Exley R, van der Veen S, van de Beek D, van der Ende A.

PLoS One. 2012;7(10):e47973. doi: 10.1371/journal.pone.0047973. Epub 2012 Oct 23.

PMID:
23110143
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Design of meningococcal factor H binding protein mutant vaccines that do not bind human complement factor H.

Pajon R, Beernink PT, Granoff DM.

Infect Immun. 2012 Aug;80(8):2667-77. doi: 10.1128/IAI.00103-12. Epub 2012 May 21. Erratum in: Infect Immun. 2014 Apr;82(4):1742.

PMID:
22615247
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice.

Rossi R, Granoff DM, Beernink PT.

Vaccine. 2013 Nov 4;31(46):5451-7. doi: 10.1016/j.vaccine.2013.08.099. Epub 2013 Sep 11.

PMID:
24035433
[PubMed - indexed for MEDLINE]
10.

Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity.

Giuntini S, Beernink PT, Reason DC, Granoff DM.

PLoS One. 2012;7(3):e34272. doi: 10.1371/journal.pone.0034272. Epub 2012 Mar 26.

PMID:
22461909
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis.

Lewis LA, Vu DM, Vasudhev S, Shaughnessy J, Granoff DM, Ram S.

MBio. 2013 Oct 15;4(5):e00339-13. doi: 10.1128/mBio.00339-13.

PMID:
24129254
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Impaired immunogenicity of a meningococcal factor H-binding protein vaccine engineered to eliminate factor h binding.

Beernink PT, Shaughnessy J, Ram S, Granoff DM.

Clin Vaccine Immunol. 2010 Jul;17(7):1074-8. doi: 10.1128/CVI.00103-10. Epub 2010 Jun 2.

PMID:
20519444
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Bactericidal antibody responses induced by meningococcal recombinant chimeric factor H-binding protein vaccines.

Beernink PT, Granoff DM.

Infect Immun. 2008 Jun;76(6):2568-75. doi: 10.1128/IAI.00033-08. Epub 2008 Mar 24.

PMID:
18362128
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Complement-mediated bactericidal activity of anti-factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding.

Giuntini S, Reason DC, Granoff DM.

Infect Immun. 2011 Sep;79(9):3751-9. doi: 10.1128/IAI.05182-11. Epub 2011 Jun 27.

PMID:
21708990
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Importance of inhibition of binding of complement factor H for serum bactericidal antibody responses to meningococcal factor H-binding protein vaccines.

Konar M, Granoff DM, Beernink PT.

J Infect Dis. 2013 Aug 15;208(4):627-36. doi: 10.1093/infdis/jit239. Epub 2013 May 28.

PMID:
23715659
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Functional impacts of the diversity of the meningococcal factor H binding protein.

Hong E, Giorgini D, Deghmane AE, Taha MK.

Vaccine. 2012 Dec 17;31(1):183-9. doi: 10.1016/j.vaccine.2012.10.072. Epub 2012 Oct 30.

PMID:
23123023
[PubMed - indexed for MEDLINE]
17.

Meningococcal factor H binding proteins in epidemic strains from Africa: implications for vaccine development.

Pajon R, Fergus AM, Koeberling O, Caugant DA, Granoff DM.

PLoS Negl Trop Dis. 2011 Sep;5(9):e1302. doi: 10.1371/journal.pntd.0001302. Epub 2011 Sep 6.

PMID:
21909444
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies.

Seib KL, Brunelli B, Brogioni B, Palumbo E, Bambini S, Muzzi A, DiMarcello F, Marchi S, van der Ende A, Aricó B, Savino S, Scarselli M, Comanducci M, Rappuoli R, Giuliani MM, Pizza M.

Infect Immun. 2011 Feb;79(2):970-81. doi: 10.1128/IAI.00891-10. Epub 2010 Dec 13.

PMID:
21149595
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement.

Lewis LA, Ngampasutadol J, Wallace R, Reid JE, Vogel U, Ram S.

PLoS Pathog. 2010 Jul 29;6(7):e1001027. doi: 10.1371/journal.ppat.1001027.

PMID:
20686663
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Functional comparison of the binding of factor H short consensus repeat 6 (SCR 6) to factor H binding protein from Neisseria meningitidis and the binding of factor H SCR 18 to 20 to Neisseria gonorrhoeae porin.

Shaughnessy J, Lewis LA, Jarva H, Ram S.

Infect Immun. 2009 May;77(5):2094-103. doi: 10.1128/IAI.01561-08. Epub 2009 Mar 9.

PMID:
19273554
[PubMed - indexed for MEDLINE]
Free PMC Article

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