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From biomarkers to a clue of biology: a computation-aided perspective of immune gene expression profiles in human type 1 diabetes.

Han D, Cai X, Wen J, Kenyon NS, Chen Z.

Front Immunol. 2012 Oct 25;3:320. doi: 10.3389/fimmu.2012.00320. eCollection 2012.


Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes.

Han D, Cai X, Wen J, Matheson D, Skyler JS, Kenyon NS, Chen Z.

Clin Exp Immunol. 2012 Nov;170(2):131-8. doi: 10.1111/j.1365-2249.2012.04650.x.


CTLA4 gene variants in autoimmunity and cancer: a comparative review.

Ghaderi A.

Iran J Immunol. 2011 Sep;8(3):127-49. doi: IJIv8i3A1. Review.


CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.

Bergholdt R, Taxvig C, Eising S, Nerup J, Pociot F.

J Leukoc Biol. 2005 Apr;77(4):579-85. Epub 2005 Jan 3.


Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling.

Elo LL, Mykkänen J, Nikula T, Järvenpää H, Simell S, Aittokallio T, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O, Lahesmaa R.

J Autoimmun. 2010 Aug;35(1):70-6. doi: 10.1016/j.jaut.2010.03.001. Epub 2010 Mar 30.


Pancreatic islet autoimmunity.

Boitard C.

Presse Med. 2012 Dec;41(12 P 2):e636-50. doi: 10.1016/j.lpm.2012.10.003. Epub 2012 Nov 22. Review.


Global gene expression changes in type 1 diabetes: insights into autoimmune response in the target organ and in the periphery.

Planas R, Pujol-Borrell R, Vives-Pi M.

Immunol Lett. 2010 Oct 30;133(2):55-61. doi: 10.1016/j.imlet.2010.08.001. Epub 2010 Aug 11. Review.


Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes.

Planas R, Carrillo J, Sanchez A, de Villa MC, Nuñez F, Verdaguer J, James RF, Pujol-Borrell R, Vives-Pi M.

Clin Exp Immunol. 2010 Jan;159(1):23-44. doi: 10.1111/j.1365-2249.2009.04053.x. Epub 2009 Nov 11.


Functional evaluation of the type 1 diabetes (T1D) susceptibility candidate genes.

Park Y.

Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S110-5. Epub 2007 Apr 19. Review.


Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity.

Regnault B, Osorio Y Fortea J, Miao D, Eisenbarth G, Melanitou E.

BMC Med Genomics. 2009 Oct 2;2:63. doi: 10.1186/1755-8794-2-63.


CTLA4 is differentially associated with autoimmune diseases in the Dutch population.

Zhernakova A, Eerligh P, Barrera P, Wesoly JZ, Huizinga TW, Roep BO, Wijmenga C, Koeleman BP.

Hum Genet. 2005 Oct;118(1):58-66. Epub 2005 Jul 16. Erratum in: Hum Genet. 2006 Mar;119(1-2):225. Weseloy, Joanna Z [corrected to Wesoly, Joanna Z].


Foxp3+ Treg expanded from patients with established diabetes reduce Helios expression while retaining normal function compared to healthy individuals.

Du W, Shen YW, Lee WH, Wang D, Paz S, Kandeel F, Liu CP.

PLoS One. 2013;8(2):e56209. doi: 10.1371/journal.pone.0056209. Epub 2013 Feb 11.


Evidence of association with type 1 diabetes in the SLC11A1 gene region.

Yang JH, Downes K, Howson JM, Nutland S, Stevens HE, Walker NM, Todd JA.

BMC Med Genet. 2011 Apr 27;12:59. doi: 10.1186/1471-2350-12-59.


Up-regulation of fas and fasL pro-apoptotic genes expression in type 1 diabetes patients after autologous haematopoietic stem cell transplantation.

de Oliveira GL, Malmegrim KC, Ferreira AF, Tognon R, Kashima S, Couri CE, Covas DT, Voltarelli JC, de Castro FA.

Clin Exp Immunol. 2012 Jun;168(3):291-302. doi: 10.1111/j.1365-2249.2012.04583.x.


Protective role of anti-idiotypic antibodies in autoimmunity--lessons for type 1 diabetes.

Hampe CS.

Autoimmunity. 2012 Jun;45(4):320-31. doi: 10.3109/08916934.2012.659299. Epub 2012 Feb 23. Review.


Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

Smyth DJ, Howson JM, Payne F, Maier LM, Bailey R, Holland K, Lowe CE, Cooper JD, Hulme JS, Vella A, Dahlman I, Lam AC, Nutland S, Walker NM, Twells RC, Todd JA.

BMC Med Genet. 2006 Mar 6;7:20.


Foxp3(+) regulatory T cells in mouse models of type 1 diabetes.

Petzold C, Riewaldt J, Watts D, Sparwasser T, Schallenberg S, Kretschmer K.

J Diabetes Res. 2013;2013:940710. doi: 10.1155/2013/940710. Epub 2013 Mar 14.


Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation.

Jailwala P, Waukau J, Glisic S, Jana S, Ehlenbach S, Hessner M, Alemzadeh R, Matsuyama S, Laud P, Wang X, Ghosh S.

PLoS One. 2009 Aug 5;4(8):e6527. doi: 10.1371/journal.pone.0006527.


What causes type 1 diabetes? Lessons from animal models.

Buschard K.

APMIS Suppl. 2011 Jul;(132):1-19. doi: 10.1111/j.1600-0463.2011.02765.x. Review.


Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes.

Li CR, Baaten BJ, Bradley LM.

J Mol Cell Biol. 2012 Feb;4(1):38-47. doi: 10.1093/jmcb/mjr040. Epub 2011 Nov 24. Review.

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