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Items: 1 to 20 of 105


Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2.

Shi K, Kurahashi K, Gao R, Tsutakawa SE, Tainer JA, Pommier Y, Aihara H.

Nat Struct Mol Biol. 2012 Dec;19(12):1372-7. doi: 10.1038/nsmb.2423. Epub 2012 Oct 28.


Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).

Gao R, Schellenberg MJ, Huang SY, Abdelmalak M, Marchand C, Nitiss KC, Nitiss JL, Williams RS, Pommier Y.

J Biol Chem. 2014 Jun 27;289(26):17960-9. doi: 10.1074/jbc.M114.565374. Epub 2014 May 7.


Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

Pommier Y, Huang SY, Gao R, Das BB, Murai J, Marchand C.

DNA Repair (Amst). 2014 Jul;19:114-29. doi: 10.1016/j.dnarep.2014.03.020. Epub 2014 May 22. Review.


Pleiotropic functions of EAPII/TTRAP/TDP2: cancer development, chemoresistance and beyond.

Li C, Sun SY, Khuri FR, Li R.

Cell Cycle. 2011 Oct 1;10(19):3274-83. doi: 10.4161/cc.10.19.17763. Epub 2011 Oct 1. Review.


Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.

Schellenberg MJ, Appel CD, Adhikari S, Robertson PD, Ramsden DA, Williams RS.

Nat Struct Mol Biol. 2012 Dec;19(12):1363-71. doi: 10.1038/nsmb.2418. Epub 2012 Oct 28.


TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF.

Nucleic Acids Res. 2012 Sep 1;40(17):8371-80. Epub 2012 Jun 26.


Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses.

Königer C, Wingert I, Marsmann M, Rösler C, Beck J, Nassal M.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4244-53. doi: 10.1073/pnas.1409986111. Epub 2014 Sep 8.


Development of a novel assay for human tyrosyl DNA phosphodiesterase 2.

Adhikari S, Karmahapatra SK, Elias H, Dhopeshwarkar P, Williams RS, Byers S, Uren A, Roy R.

Anal Biochem. 2011 Sep 1;416(1):112-6. doi: 10.1016/j.ab.2011.05.008. Epub 2011 May 12.


An RNA virus hijacks an incognito function of a DNA repair enzyme.

Virgen-Slane R, Rozovics JM, Fitzgerald KD, Ngo T, Chou W, van der Heden van Noort GJ, Filippov DV, Gershon PD, Semler BL.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14634-9. doi: 10.1073/pnas.1208096109. Epub 2012 Aug 20.


Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

Schellenberg MJ, Perera L, Strom CN, Waters CA, Monian B, Appel CD, Vilas CK, Williams JG, Ramsden DA, Williams RS.

Nucleic Acids Res. 2016 May 5;44(8):3829-44. doi: 10.1093/nar/gkw228. Epub 2016 Apr 8.


Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose.

Caldecott KW.

Nat Struct Mol Biol. 2012 Dec;19(12):1212-3. doi: 10.1038/nsmb.2455. No abstract available.


TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.

Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, Vermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F.

PLoS Genet. 2013;9(3):e1003226. doi: 10.1371/journal.pgen.1003226. Epub 2013 Mar 7.


A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.

Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K, Caldecott KW.

Nature. 2009 Oct 1;461(7264):674-8. doi: 10.1038/nature08444.


Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.

Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y.

ACS Chem Biol. 2016 May 11. [Epub ahead of print]


Crystal structure of the human Fe65-PTB1 domain.

Radzimanowski J, Ravaud S, Schlesinger S, Koch J, Beyreuther K, Sinning I, Wild K.

J Biol Chem. 2008 Aug 22;283(34):23113-20. doi: 10.1074/jbc.M800861200. Epub 2008 Jun 11.


Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.

Kont YS, Dutta A, Mallisetty A, Mathew J, Minas T, Kraus C, Dhopeshwarkar P, Kallakury B, Mitra S, Üren A, Adhikari S.

DNA Repair (Amst). 2016 Jul;43:38-47. doi: 10.1016/j.dnarep.2016.04.009. Epub 2016 May 7.


Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW.

Biochem J. 2016 Apr 20. pii: BCJ20160180. [Epub ahead of print]


Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase.

Groesch TD, Zhou F, Mattila S, Geahlen RL, Post CB.

J Mol Biol. 2006 Mar 10;356(5):1222-36. Epub 2005 Dec 27.


The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.

Tsutakawa SE, Lafrance-Vanasse J, Tainer JA.

DNA Repair (Amst). 2014 Jul;19:95-107. doi: 10.1016/j.dnarep.2014.03.022. Epub 2014 Apr 19. Review.

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