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Items: 1 to 20 of 118

1.

Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.

Buckley SM, Aranda-Orgilles B, Strikoudis A, Apostolou E, Loizou E, Moran-Crusio K, Farnsworth CL, Koller AA, Dasgupta R, Silva JC, Stadtfeld M, Hochedlinger K, Chen EI, Aifantis I.

Cell Stem Cell. 2012 Dec 7;11(6):783-98. doi: 10.1016/j.stem.2012.09.011. Epub 2012 Oct 25.

2.

Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2.

Nakajima T, Kitagawa K, Ohhata T, Sakai S, Uchida C, Shibata K, Minegishi N, Yumimoto K, Nakayama KI, Masumoto K, Katou F, Niida H, Kitagawa M.

J Biol Chem. 2015 Apr 17;290(16):10368-81. doi: 10.1074/jbc.M114.613018. Epub 2015 Feb 10.

3.

Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells.

Jang J, Wang Y, Kim HS, Lalli MA, Kosik KS.

Stem Cells. 2014 Oct;32(10):2616-25. doi: 10.1002/stem.1764.

4.

Triggering Fbw7-mediated proteasomal degradation of c-Myc by oridonin induces cell growth inhibition and apoptosis.

Huang HL, Weng HY, Wang LQ, Yu CH, Huang QJ, Zhao PP, Wen JZ, Zhou H, Qu LH.

Mol Cancer Ther. 2012 May;11(5):1155-65. doi: 10.1158/1535-7163.MCT-12-0066. Epub 2012 Mar 2.

5.

Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability.

Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z.

Stem Cells. 2014 Mar;32(3):623-35. doi: 10.1002/stem.1580.

6.

TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells.

Sato T, Okumura F, Ariga T, Hatakeyama S.

J Cell Sci. 2012 Mar 15;125(Pt 6):1544-55. doi: 10.1242/jcs.095273. Epub 2012 Feb 10.

7.

Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation.

Okita Y, Matsumoto A, Yumimoto K, Isoshita R, Nakayama KI.

Genes Cells. 2012 Sep;17(9):768-77. doi: 10.1111/j.1365-2443.2012.01626.x. Epub 2012 Aug 16.

8.

Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.

Kanei-Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama KI, Ishii S.

J Biol Chem. 2008 Nov 7;283(45):30540-8. doi: 10.1074/jbc.M804340200. Epub 2008 Sep 2.

9.

The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming.

Wang L, Miao YL, Zheng X, Lackford B, Zhou B, Han L, Yao C, Ward JM, Burkholder A, Lipchina I, Fargo DC, Hochedlinger K, Shi Y, Williams CJ, Hu G.

Cell Stem Cell. 2013 Dec 5;13(6):676-90. doi: 10.1016/j.stem.2013.10.008.

10.

F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.

Yumimoto K, Matsumoto M, Onoyama I, Imaizumi K, Nakayama KI.

J Biol Chem. 2013 Oct 4;288(40):28488-502. doi: 10.1074/jbc.M113.465179. Epub 2013 Aug 16.

11.

Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond.

Kourtis N, Strikoudis A, Aifantis I.

Curr Opin Cell Biol. 2015 Dec;37:28-34. doi: 10.1016/j.ceb.2015.09.003. Epub 2015 Sep 28. Review.

PMID:
26426760
12.

The transcriptional regulation of pluripotency.

Yeo JC, Ng HH.

Cell Res. 2013 Jan;23(1):20-32. doi: 10.1038/cr.2012.172. Epub 2012 Dec 11. Review.

13.

O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network.

Jang H, Kim TW, Yoon S, Choi SY, Kang TW, Kim SY, Kwon YW, Cho EJ, Youn HD.

Cell Stem Cell. 2012 Jul 6;11(1):62-74. doi: 10.1016/j.stem.2012.03.001. Epub 2012 May 17.

14.

Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.

Thompson JW, Nagel J, Hoving S, Gerrits B, Bauer A, Thomas JR, Kirschner MW, Schirle M, Luchansky SJ.

J Biol Chem. 2014 Oct 17;289(42):28942-55. doi: 10.1074/jbc.M114.573352. Epub 2014 Aug 21.

15.

Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction.

Liao B, Zhong X, Xu H, Xiao F, Fang Z, Gu J, Chen Y, Zhao Y, Jin Y.

J Cell Physiol. 2013 Jul;228(7):1443-51. doi: 10.1002/jcp.24297.

PMID:
23255053
16.

E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation.

Lochab S, Pal P, Kapoor I, Kanaujiya JK, Sanyal S, Behre G, Trivedi AK.

Biochim Biophys Acta. 2013 Dec;1833(12):2639-52. doi: 10.1016/j.bbamcr.2013.06.018. Epub 2013 Jun 29.

17.

Role of the ubiquitin proteasome system in hematologic malignancies.

Sahasrabuddhe AA, Elenitoba-Johnson KS.

Immunol Rev. 2015 Jan;263(1):224-39. doi: 10.1111/imr.12236. Review.

PMID:
25510280
18.

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.

Hirsch CL, Coban Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY.

Genes Dev. 2015 Apr 15;29(8):803-16. doi: 10.1101/gad.255109.114. Epub 2015 Apr 15. Erratum in: Genes Dev. 2015 Jun 15;29(12):1341.

19.

The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.

Sun XX, He X, Yin L, Komada M, Sears RC, Dai MS.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3734-9. doi: 10.1073/pnas.1411713112. Epub 2015 Mar 9.

20.

A label-free quantitative proteomics strategy to identify E3 ubiquitin ligase substrates targeted to proteasome degradation.

Burande CF, Heuzé ML, Lamsoul I, Monsarrat B, Uttenweiler-Joseph S, Lutz PG.

Mol Cell Proteomics. 2009 Jul;8(7):1719-27. doi: 10.1074/mcp.M800410-MCP200. Epub 2009 Apr 17.

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