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Results: 1 to 20 of 126

1.

The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.

Alemi F, Poole DP, Chiu J, Schoonjans K, Cattaruzza F, Grider JR, Bunnett NW, Corvera CU.

Gastroenterology. 2013 Jan;144(1):145-54. doi: 10.1053/j.gastro.2012.09.055. Epub 2012 Oct 3.

PMID:
23041323
[PubMed - indexed for MEDLINE]
2.

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.

Poole DP, Godfrey C, Cattaruzza F, Cottrell GS, Kirkland JG, Pelayo JC, Bunnett NW, Corvera CU.

Neurogastroenterol Motil. 2010 Jul;22(7):814-25, e227-8. doi: 10.1111/j.1365-2982.2010.01487.x. Epub 2010 Mar 12.

PMID:
20236244
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice.

Péan N, Doignon I, Garcin I, Besnard A, Julien B, Liu B, Branchereau S, Spraul A, Guettier C, Humbert L, Schoonjans K, Rainteau D, Tordjmann T.

Hepatology. 2013 Oct;58(4):1451-60. doi: 10.1002/hep.26463. Epub 2013 Aug 19.

PMID:
23686672
[PubMed - indexed for MEDLINE]
4.

Effect of progesterone on colonic motility and fecal output in mice with diarrhea.

Li CP, Ling C, Biancani P, Behar J.

Neurogastroenterol Motil. 2012 Apr;24(4):392-e174. doi: 10.1111/j.1365-2982.2011.01875.x. Epub 2012 Jan 27.

PMID:
22284724
[PubMed - indexed for MEDLINE]
5.

Muscarinic receptor subtypes involved in regulation of colonic motility in mice: functional studies using muscarinic receptor-deficient mice.

Kondo T, Nakajima M, Teraoka H, Unno T, Komori S, Yamada M, Kitazawa T.

Eur J Pharmacol. 2011 Nov 16;670(1):236-43. doi: 10.1016/j.ejphar.2011.08.034. Epub 2011 Sep 10.

PMID:
21924260
[PubMed - indexed for MEDLINE]
6.

The TGR5 receptor mediates bile acid-induced itch and analgesia.

Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU.

J Clin Invest. 2013 Apr 1;123(4):1513-30. doi: 10.1172/JCI64551. Epub 2013 Mar 25.

PMID:
23524965
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU.

J Biol Chem. 2013 Aug 9;288(32):22942-60. doi: 10.1074/jbc.M113.455774. Epub 2013 Jul 1.

PMID:
23818521
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

GPBA: a GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation.

Lieu T, Jayaweera G, Bunnett NW.

Br J Pharmacol. 2014 Mar;171(5):1156-66. doi: 10.1111/bph.12426. Review.

PMID:
24111923
[PubMed - indexed for MEDLINE]
9.

The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.

Li T, Holmstrom SR, Kir S, Umetani M, Schmidt DR, Kliewer SA, Mangelsdorf DJ.

Mol Endocrinol. 2011 Jun;25(6):1066-71. doi: 10.1210/me.2010-0460. Epub 2011 Mar 31.

PMID:
21454404
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders.

Camilleri M, Vazquez-Roque MI, Carlson P, Burton D, Wong BS, Zinsmeister AR.

Neurogastroenterol Motil. 2011 Nov;23(11):995-9, e458. doi: 10.1111/j.1365-2982.2011.01772.x. Epub 2011 Aug 24.

PMID:
21883702
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Desensitization of the peristaltic reflex induced by mucosal stimulation with the selective 5-HT4 agonist tegaserod.

Grider JR.

Am J Physiol Gastrointest Liver Physiol. 2006 Feb;290(2):G319-27. Epub 2005 Oct 13.

PMID:
16223945
[PubMed - indexed for MEDLINE]
Free Article
12.

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.

Lieu T, Jayaweera G, Zhao P, Poole DP, Jensen D, Grace M, McIntyre P, Bron R, Wilson YM, Krappitz M, Haerteis S, Korbmacher C, Steinhoff MS, Nassini R, Materazzi S, Geppetti P, Corvera CU, Bunnett NW.

Gastroenterology. 2014 Dec;147(6):1417-28. doi: 10.1053/j.gastro.2014.08.042. Epub 2014 Sep 3.

PMID:
25194674
[PubMed - in process]
13.

Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine.

Poole DP, Pelayo JC, Cattaruzza F, Kuo YM, Gai G, Chiu JV, Bron R, Furness JB, Grady EF, Bunnett NW.

Gastroenterology. 2011 Aug;141(2):565-75, 575.e1-4. doi: 10.1053/j.gastro.2011.04.049. Epub 2011 May 4.

PMID:
21689654
[PubMed - indexed for MEDLINE]
14.

Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice.

Moriya R, Fujikawa T, Ito J, Shirakura T, Hirose H, Suzuki J, Fukuroda T, Macneil DJ, Kanatani A.

Eur J Pharmacol. 2010 Feb 10;627(1-3):258-64. doi: 10.1016/j.ejphar.2009.09.057. Epub 2009 Oct 8.

PMID:
19818748
[PubMed - indexed for MEDLINE]
15.

Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.

Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G527-35. doi: 10.1152/ajpgi.00388.2012. Epub 2012 Dec 28.

PMID:
23275618
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.

Hoffman JM, Tyler K, MacEachern SJ, Balemba OB, Johnson AC, Brooks EM, Zhao H, Swain GM, Moses PL, Galligan JJ, Sharkey KA, Greenwood-Van Meerveld B, Mawe GM.

Gastroenterology. 2012 Apr;142(4):844-854.e4. doi: 10.1053/j.gastro.2011.12.041. Epub 2012 Jan 4.

PMID:
22226658
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons.

Grider JR, Kuemmerle JF, Jin JG.

Am J Physiol. 1996 May;270(5 Pt 1):G778-82.

PMID:
8967488
[PubMed - indexed for MEDLINE]
18.

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease.

Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume MT, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, Koganei K, Sugita A, Kanai T, Hibi T.

Immunology. 2013 May;139(1):19-29. doi: 10.1111/imm.12045.

PMID:
23566200
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon.

Ward JB, Mroz MS, Keely SJ.

Neurogastroenterol Motil. 2013 Aug;25(8):708-11. doi: 10.1111/nmo.12148. Epub 2013 May 1.

PMID:
23634890
[PubMed - indexed for MEDLINE]
20.

Release of 5-hydroxytryptamine from the mucosa is not required for the generation or propagation of colonic migrating motor complexes.

Keating DJ, Spencer NJ.

Gastroenterology. 2010 Feb;138(2):659-70 670.e1-2. doi: 10.1053/j.gastro.2009.09.020. Epub 2009 Sep 24.

PMID:
19782081
[PubMed - indexed for MEDLINE]
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