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Items: 1 to 20 of 105

1.

Bmi1 is required for hepatic progenitor cell expansion and liver tumor development.

Fan L, Xu C, Wang C, Tao J, Ho C, Jiang L, Gui B, Huang S, Evert M, Calvisi DF, Chen X.

PLoS One. 2012;7(9):e46472. doi: 10.1371/journal.pone.0046472. Epub 2012 Sep 28.

2.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.

Hepatology. 2010 Sep;52(3):1111-23. doi: 10.1002/hep.23793.

PMID:
20648475
3.

Bmi1 functions as an oncogene independent of Ink4A/Arf repression in hepatic carcinogenesis.

Xu CR, Lee S, Ho C, Bommi P, Huang SA, Cheung ST, Dimri GP, Chen X.

Mol Cancer Res. 2009 Dec;7(12):1937-45. doi: 10.1158/1541-7786.MCR-09-0333. Epub 2009 Nov 24.

4.

Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.

Liu Y, Liu F, Yu H, Zhao X, Sashida G, Deblasio A, Harr M, She QB, Chen Z, Lin HK, Di Giandomenico S, Elf SE, Yang Y, Miyata Y, Huang G, Menendez S, Mellinghoff IK, Rosen N, Pandolfi PP, Hedvat CV, Nimer SD.

Sci Signal. 2012 Oct 23;5(247):ra77. doi: 10.1126/scisignal.2003199.

5.

Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.

Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J, van Tellingen O, van Lohuizen M.

Cancer Cell. 2007 Oct;12(4):328-41.

6.

BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor.

Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD.

Nat Cell Biol. 2013 Jul;15(7):846-52. doi: 10.1038/ncb2766. Epub 2013 Jun 2.

7.

Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation.

Kim HG, Kim DJ, Li S, Lee KY, Li X, Bode AM, Dong Z.

J Biol Chem. 2012 Sep 14;287(38):31920-8. doi: 10.1074/jbc.M112.360362. Epub 2012 Jul 28.

8.

Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.

Kranc KR, Bamforth SD, Bragança J, Norbury C, van Lohuizen M, Bhattacharya S.

Mol Cell Biol. 2003 Nov;23(21):7658-66.

9.

Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.

Bednar F, Schofield HK, Collins MA, Yan W, Zhang Y, Shyam N, Eberle JA, Almada LL, Olive KP, Bardeesy N, Fernandez-Zapico ME, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M.

Carcinogenesis. 2015 Jul;36(7):730-8. doi: 10.1093/carcin/bgv058. Epub 2015 May 4.

10.

Conditional activation of Bmi1 expression regulates self-renewal, apoptosis, and differentiation of neural stem/progenitor cells in vitro and in vivo.

Yadirgi G, Leinster V, Acquati S, Bhagat H, Shakhova O, Marino S.

Stem Cells. 2011 Apr;29(4):700-12. doi: 10.1002/stem.614.

11.

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch.

López-Arribillaga E, Rodilla V, Pellegrinet L, Guiu J, Iglesias M, Roman AC, Gutarra S, González S, Muñoz-Cánoves P, Fernández-Salguero P, Radtke F, Bigas A, Espinosa L.

Development. 2015 Jan 1;142(1):41-50. doi: 10.1242/dev.107714. Epub 2014 Dec 5.

12.

Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.

Dovey JS, Zacharek SJ, Kim CF, Lees JA.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11857-62. doi: 10.1073/pnas.0803574105. Epub 2008 Aug 12.

13.

The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.

Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A.

J Hepatol. 2010 Jun;52(6):854-63. doi: 10.1016/j.jhep.2010.01.027. Epub 2010 Mar 24.

PMID:
20395008
14.

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

Bruggeman SW, Valk-Lingbeek ME, van der Stoop PP, Jacobs JJ, Kieboom K, Tanger E, Hulsman D, Leung C, Arsenijevic Y, Marino S, van Lohuizen M.

Genes Dev. 2005 Jun 15;19(12):1438-43.

15.

Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.

Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H, Iwama A.

J Exp Med. 2012 Mar 12;209(3):445-54. doi: 10.1084/jem.20111709. Epub 2012 Feb 20.

16.

A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.

Negishi M, Saraya A, Mochizuki S, Helin K, Koseki H, Iwama A.

PLoS One. 2010 Aug 24;5(8):e12373. doi: 10.1371/journal.pone.0012373.

17.

Validation of Bmi1 as a therapeutic target of hepatocellular carcinoma in mice.

Qi S, Li B, Yang T, Liu Y, Cao S, He X, Zhang P, Li L, Xu C.

Int J Mol Sci. 2014 Nov 3;15(11):20004-21. doi: 10.3390/ijms151120004.

18.

Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion.

Michael LE, Westerman BA, Ermilov AN, Wang A, Ferris J, Liu J, Blom M, Ellison DW, van Lohuizen M, Dlugosz AA.

Neoplasia. 2008 Dec;10(12):1343-9, 5p following 1349.

19.

Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer.

Becker M, Korn C, Sienerth AR, Voswinckel R, Luetkenhaus K, Ceteci F, Rapp UR.

PLoS One. 2009;4(1):e4230. doi: 10.1371/journal.pone.0004230. Epub 2009 Jan 19.

20.

The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.

Chiba T, Miyagi S, Saraya A, Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A.

Cancer Res. 2008 Oct 1;68(19):7742-9. doi: 10.1158/0008-5472.CAN-07-5882.

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