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De novo CNV formation in mouse embryonic stem cells occurs in the absence of Xrcc4-dependent nonhomologous end joining.

Arlt MF, Rajendran S, Birkeland SR, Wilson TE, Glover TW.

PLoS Genet. 2012 Sep;8(9):e1002981. doi: 10.1371/journal.pgen.1002981. Epub 2012 Sep 20.


Hydroxyurea induces de novo copy number variants in human cells.

Arlt MF, Ozdemir AC, Birkeland SR, Wilson TE, Glover TW.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17360-5. doi: 10.1073/pnas.1109272108. Epub 2011 Oct 10.


Time-dependent predominance of nonhomologous DNA end-joining pathways during embryonic development in mice.

Chiruvella KK, Sebastian R, Sharma S, Karande AA, Choudhary B, Raghavan SC.

J Mol Biol. 2012 Mar 30;417(3):197-211. doi: 10.1016/j.jmb.2012.01.029. Epub 2012 Jan 27.


Copy number variants are produced in response to low-dose ionizing radiation in cultured cells.

Arlt MF, Rajendran S, Birkeland SR, Wilson TE, Glover TW.

Environ Mol Mutagen. 2014 Mar;55(2):103-13. doi: 10.1002/em.21840. Epub 2013 Dec 10.


Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation.

Simsek D, Jasin M.

Nat Struct Mol Biol. 2010 Apr;17(4):410-6. doi: 10.1038/nsmb.1773. Epub 2010 Mar 7.


Origins and breakpoint analyses of copy number variations: up close and personal.

van Binsbergen E.

Cytogenet Genome Res. 2011;135(3-4):271-6. doi: 10.1159/000330267. Epub 2011 Aug 12. Review.


Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks.

Tichy ED, Pillai R, Deng L, Liang L, Tischfield J, Schwemberger SJ, Babcock GF, Stambrook PJ.

Stem Cells Dev. 2010 Nov;19(11):1699-711. doi: 10.1089/scd.2010.0058. Epub 2010 Aug 5.


Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.

Eccleston J, Yan C, Yuan K, Alt FW, Selsing E.

J Immunol. 2011 Feb 15;186(4):2336-43. doi: 10.4049/jimmunol.1003104. Epub 2011 Jan 17.


Mechanisms of DNA double strand break repair and chromosome aberration formation.

Iliakis G, Wang H, Perrault AR, Boecker W, Rosidi B, Windhofer F, Wu W, Guan J, Terzoudi G, Pantelias G.

Cytogenet Genome Res. 2004;104(1-4):14-20. Review.


Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants.

Arlt MF, Mulle JG, Schaibley VM, Ragland RL, Durkin SG, Warren ST, Glover TW.

Am J Hum Genet. 2009 Mar;84(3):339-50. doi: 10.1016/j.ajhg.2009.01.024. Epub 2009 Feb 19.


The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV.

Kuhfittig-Kulle S, Feldmann E, Odersky A, Kuliczkowska A, Goedecke W, Eggert A, Pfeiffer P.

Mutagenesis. 2007 May;22(3):217-33. Epub 2007 Mar 7.


Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4.

Terasawa M, Shinohara A, Shinohara M.

PLoS Genet. 2014 Aug 28;10(8):e1004563. doi: 10.1371/journal.pgen.1004563. eCollection 2014 Aug.


Alternative pathways for the repair of RAG-induced DNA breaks.

Weinstock DM, Jasin M.

Mol Cell Biol. 2006 Jan;26(1):131-9.


Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks.

Schulte-Uentrop L, El-Awady RA, Schliecker L, Willers H, Dahm-Daphi J.

Nucleic Acids Res. 2008 May;36(8):2561-9. doi: 10.1093/nar/gkn094. Epub 2008 Mar 10.


Differences in sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient human cells.

Katsube T, Mori M, Tsuji H, Shiomi T, Shiomi N, Onoda M.

J Radiat Res. 2011;52(4):415-24. doi: 10.1269/jrr.10168.


Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks.

Rothkamm K, Kühne M, Jeggo PA, Löbrich M.

Cancer Res. 2001 May 15;61(10):3886-93.


Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends.

Guirouilh-Barbat J, Rass E, Plo I, Bertrand P, Lopez BS.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20902-7. Epub 2007 Dec 18.


XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.

Ahnesorg P, Smith P, Jackson SP.

Cell. 2006 Jan 27;124(2):301-13.


Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing.

Arlt MF, Ozdemir AC, Birkeland SR, Lyons RH Jr, Glover TW, Wilson TE.

Genetics. 2011 Mar;187(3):675-83. doi: 10.1534/genetics.110.124776. Epub 2011 Jan 6.

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