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Items: 1 to 20 of 114

1.

A 22-mer segment in the structurally pliable regulatory domain of metazoan CTP: phosphocholine cytidylyltransferase facilitates both silencing and activating functions.

Ding Z, Taneva SG, Huang HK, Campbell SA, Semenec L, Chen N, Cornell RB.

J Biol Chem. 2012 Nov 9;287(46):38980-91. doi: 10.1074/jbc.M112.402081. Epub 2012 Sep 17.

2.

Contribution of each membrane binding domain of the CTP:phosphocholine cytidylyltransferase-alpha dimer to its activation, membrane binding, and membrane cross-bridging.

Taneva S, Dennis MK, Ding Z, Smith JL, Cornell RB.

J Biol Chem. 2008 Oct 17;283(42):28137-48. doi: 10.1074/jbc.M802595200. Epub 2008 Aug 11.

3.

The amphipathic helix of an enzyme that regulates phosphatidylcholine synthesis remodels membranes into highly curved nanotubules.

Taneva SG, Lee JM, Cornell RB.

Biochim Biophys Acta. 2012 May;1818(5):1173-86. doi: 10.1016/j.bbamem.2012.01.006. Epub 2012 Jan 18.

4.

Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold.

Lee J, Johnson J, Ding Z, Paetzel M, Cornell RB.

J Biol Chem. 2009 Nov 27;284(48):33535-48. doi: 10.1074/jbc.M109.053363. Epub 2009 Sep 25.

5.
6.

The membrane-binding domain of an amphitropic enzyme suppresses catalysis by contact with an amphipathic helix flanking its active site.

Huang HK, Taneva SG, Lee J, Silva LP, Schriemer DC, Cornell RB.

J Mol Biol. 2013 May 13;425(9):1546-64. doi: 10.1016/j.jmb.2012.12.003. Epub 2012 Dec 10. Erratum in: J Mol Biol. 2013 Sep 23;425(18):3576.

PMID:
23238251
8.
9.
10.

Functions of membrane binding domain of CTP:phosphocholine cytidylyltransferase in alveolar type II cells.

Ridsdale R, Tseu I, Wang J, Post M.

Am J Respir Cell Mol Biol. 2010 Jul;43(1):74-87. doi: 10.1165/rcmb.2009-0231OC. Epub 2009 Aug 14.

PMID:
19684306
11.

Structural basis for autoinhibition of CTP:phosphocholine cytidylyltransferase (CCT), the regulatory enzyme in phosphatidylcholine synthesis, by its membrane-binding amphipathic helix.

Lee J, Taneva SG, Holland BW, Tieleman DP, Cornell RB.

J Biol Chem. 2014 Jan 17;289(3):1742-55. doi: 10.1074/jbc.M113.526970. Epub 2013 Nov 25.

12.

CTP:phosphocholine cytidylyltransferase.

Kent C.

Biochim Biophys Acta. 1997 Sep 4;1348(1-2):79-90. Review.

PMID:
9370319
13.

Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization.

Cornell RB, Northwood IC.

Trends Biochem Sci. 2000 Sep;25(9):441-7. Review.

PMID:
10973058
14.

Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum.

Nagy GN, Marton L, Krámos B, Oláh J, Révész Á, Vékey K, Delsuc F, Hunyadi-Gulyás É, Medzihradszky KF, Lavigne M, Vial H, Cerdan R, Vértessy BG.

FEBS J. 2013 Jul;280(13):3132-48. doi: 10.1111/febs.12282. Epub 2013 May 24.

15.

Interdomain and membrane interactions of CTP:phosphocholine cytidylyltransferase revealed via limited proteolysis and mass spectrometry.

Bogan MJ, Agnes GR, Pio F, Cornell RB.

J Biol Chem. 2005 May 20;280(20):19613-24. Epub 2005 Feb 15.

16.

CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis.

Cornell RB, Ridgway ND.

Prog Lipid Res. 2015 Jul;59:147-71. doi: 10.1016/j.plipres.2015.07.001. Epub 2015 Jul 9. Review.

PMID:
26165797
17.

The intrinsically disordered nuclear localization signal and phosphorylation segments distinguish the membrane affinity of two cytidylyltransferase isoforms.

Dennis MK, Taneva SG, Cornell RB.

J Biol Chem. 2011 Apr 8;286(14):12349-60. doi: 10.1074/jbc.M110.201715. Epub 2011 Feb 8.

19.

The curvature sensitivity of a membrane-binding amphipathic helix can be modulated by the charge on a flanking region.

Chong SS, Taneva SG, Lee JM, Cornell RB.

Biochemistry. 2014 Jan 28;53(3):450-61. doi: 10.1021/bi401457r. Epub 2014 Jan 15.

PMID:
24397368
20.

CTP:phosphocholine cytidylyltransferase: insights into regulatory mechanisms and novel functions.

Clement JM, Kent C.

Biochem Biophys Res Commun. 1999 Apr 21;257(3):643-50. Review.

PMID:
10208837
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