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Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes.

Levy H, Wang X, Kaldunski M, Jia S, Kramer J, Pavletich SJ, Reske M, Gessel T, Yassai M, Quasney MW, Dahmer MK, Gorski J, Hessner MJ.

Genes Immun. 2012 Dec;13(8):593-604. doi: 10.1038/gene.2012.41. Epub 2012 Sep 13.


Use of transcriptional signatures induced in lymphoid and myeloid cell lines as an inflammatory biomarker in Type 1 diabetes.

Jia S, Kaldunski M, Jailwala P, Geoffrey R, Kramer J, Wang X, Hessner MJ.

Physiol Genomics. 2011 Jun 15;43(11):697-709. doi: 10.1152/physiolgenomics.00235.2010. Epub 2011 Mar 15.


Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat.

Kaldunski M, Jia S, Geoffrey R, Basken J, Prosser S, Kansra S, Mordes JP, Lernmark A, Wang X, Hessner MJ.

Diabetes. 2010 Oct;59(10):2375-85. doi: 10.2337/db10-0372. Epub 2010 Aug 3.


MicroRNAs miR-21a and miR-93 are down regulated in peripheral blood mononuclear cells (PBMCs) from patients with type 1 diabetes.

Salas-Pérez F, Codner E, Valencia E, Pizarro C, Carrasco E, Pérez-Bravo F.

Immunobiology. 2013 May;218(5):733-7. doi: 10.1016/j.imbio.2012.08.276. Epub 2012 Aug 23.


Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease.

Rieber N, Brand A, Hector A, Graepler-Mainka U, Ost M, Schäfer I, Wecker I, Neri D, Wirth A, Mays L, Zundel S, Fuchs J, Handgretinger R, Stern M, Hogardt M, Döring G, Riethmüller J, Kormann M, Hartl D.

J Immunol. 2013 Feb 1;190(3):1276-84. doi: 10.4049/jimmunol.1202144. Epub 2012 Dec 31.


Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics.

Wang X, Jia S, Geoffrey R, Alemzadeh R, Ghosh S, Hessner MJ.

J Immunol. 2008 Feb 1;180(3):1929-37.


Molecular signatures differentiate immune states in type 1 diabetic families.

Chen YG, Cabrera SM, Jia S, Kaldunski ML, Kramer J, Cheong S, Geoffrey R, Roethle MF, Woodliff JE, Greenbaum CJ, Wang X, Hessner MJ.

Diabetes. 2014 Nov;63(11):3960-73. doi: 10.2337/db14-0214. Epub 2014 Apr 23.


Common and specific signatures of gene expression and protein-protein interactions in autoimmune diseases.

Tuller T, Atar S, Ruppin E, Gurevich M, Achiron A.

Genes Immun. 2013 Mar;14(2):67-82. doi: 10.1038/gene.2012.55. Epub 2012 Nov 29.


The expression of inflammatory genes is upregulated in peripheral blood of patients with type 1 diabetes.

Jin Y, Sharma A, Carey C, Hopkins D, Wang X, Robertson DG, Bode B, Anderson SW, Reed JC, Steed RD, Steed L, She JX.

Diabetes Care. 2013 Sep;36(9):2794-802. doi: 10.2337/dc12-1986. Epub 2013 May 1.


Signal transducer and activator of transcription 4 (STAT4), but not IL-12 contributes to Pseudomonas aeruginosa-induced lung inflammation in mice.

O'Sullivan R, Carrigan SO, Marshall JS, Lin TJ.

Immunobiology. 2008;213(6):469-79. doi: 10.1016/j.imbio.2007.11.007. Epub 2008 Jan 2.


Autoreactive T cell response in CD25-negative fraction of peripheral blood mononuclear cells in established type 1 diabetes.

Moriyama H, Kotani R, Katsuta A, Kameno M, Arai T, Okumachi Y, Kishi M, Yamada K, Yasuda H, Hara K, Yokono K, Nagata M.

Ann N Y Acad Sci. 2008 Dec;1150:278-81. doi: 10.1196/annals.1447.007.


Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes.

Hunt WR, Zughaier SM, Guentert DE, Shenep MA, Koval M, McCarty NA, Hansen JM.

Am J Physiol Lung Cell Mol Physiol. 2014 Jan 1;306(1):L43-9. doi: 10.1152/ajplung.00224.2013. Epub 2013 Oct 4.


Fcgamma receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis.

De Rose V, Arduino C, Cappello N, Piana R, Salmin P, Bardessono M, Goia M, Padoan R, Bignamini E, Costantini D, Pizzamiglio G, Bennato V, Colombo C, Giunta A, Piazza A.

Eur J Hum Genet. 2005 Jan;13(1):96-101.


Association of interleukin-10 gene haplotypes with Pseudomonas aeruginosa airway colonization in cystic fibrosis.

Tesse R, Cardinale F, Santostasi T, Polizzi A, Mappa L, Manca A, De Robertis F, Silecchia O, Armenio L.

J Cyst Fibros. 2008 Jul;7(4):329-32. Epub 2008 Feb 21.


Increased expression of IL-18 in the serum and islets of type 1 diabetics.

Harms RZ, Yarde DN, Guinn Z, Lorenzo-Arteaga KM, Corley KP, Cabrera MS, Sarvetnick NE.

Mol Immunol. 2015 Apr;64(2):306-12. doi: 10.1016/j.molimm.2014.12.012. Epub 2015 Jan 7.


High T-helper-1 cytokines but low T-helper-3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes.

Stechova K, Bohmova K, Vrabelova Z, Sepa A, Stadlerova G, Zacharovova K, Faresjö M.

Diabetes Metab Res Rev. 2007 Sep;23(6):462-71.


Microarray analysis of microRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1).

Song H, Wang Q, Guo Y, Liu S, Song R, Gao X, Dai L, Li B, Zhang D, Cheng J.

BMC Infect Dis. 2013 Jun 3;13:257. doi: 10.1186/1471-2334-13-257.


Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells.

Parker D, Cohen TS, Alhede M, Harfenist BS, Martin FJ, Prince A.

Am J Respir Cell Mol Biol. 2012 Jan;46(1):6-13. doi: 10.1165/rcmb.2011-0080OC.


The effect of diabetes-associated autoantigens on cell processes in human PBMCs and their relevance to autoimmune diabetes development.

Vcelakova J, Blatny R, Halbhuber Z, Kolar M, Neuwirth A, Petruzelkova L, Ulmannova T, Kolouskova S, Sumnik Z, Pithova P, Krivjanska M, Filipp D, Stechova K.

J Diabetes Res. 2013;2013:589451. doi: 10.1155/2013/589451. Epub 2013 Jun 12.

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