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Items: 1 to 20 of 176

1.

Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial.

Roberts I, Perel P, Prieto-Merino D, Shakur H, Coats T, Hunt BJ, Lecky F, Brohi K, Willett K; CRASH-2 Collaborators.

BMJ. 2012 Sep 11;345:e5839. doi: 10.1136/bmj.e5839.

3.

The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.

Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, Cook L, Kawahara T, Perel P, Prieto-Merino D, Ramos M, Cairns J, Guerriero C.

Health Technol Assess. 2013 Mar;17(10):1-79. doi: 10.3310/hta17100.

4.

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.

CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S.

Lancet. 2010 Jul 3;376(9734):23-32. doi: 10.1016/S0140-6736(10)60835-5. Epub 2010 Jun 14.

PMID:
20554319
5.

The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.

CRASH-2 collaborators, Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T.

Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2. doi: 10.1016/S0140-6736(11)60278-X.

PMID:
21439633
6.

CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial.

Perel P, Al-Shahi Salman R, Kawahara T, Morris Z, Prieto-Merino D, Roberts I, Sandercock P, Shakur H, Wardlaw J.

Health Technol Assess. 2012;16(13):iii-xii, 1-54. doi: 10.3310/hta16130.

7.

Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study).

CRASH-2 Collaborators, Intracranial Bleeding Study.

BMJ. 2011 Jul 1;343:d3795. doi: 10.1136/bmj.d3795.

8.
9.

HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial.

Roberts I, Coats T, Edwards P, Gilmore I, Jairath V, Ker K, Manno D, Shakur H, Stanworth S, Veitch A.

Trials. 2014 Nov 19;15:450. doi: 10.1186/1745-6215-15-450.

10.

Antifibrinolytic drugs for acute traumatic injury.

Ker K, Roberts I, Shakur H, Coats TJ.

Cochrane Database Syst Rev. 2015 May 9;(5):CD004896. doi: 10.1002/14651858.CD004896.pub4. Review.

PMID:
25956410
11.

Trauma and severe bleeding. Tranexamic acid within one hour to reduce mortality.

[No authors listed]

Prescrire Int. 2013 Jul;22(140):189-90. Review.

PMID:
23951599
12.
13.

Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial.

Roberts I, Prieto-Merino D, Manno D.

Crit Care. 2014 Dec 13;18(6):685. doi: 10.1186/s13054-014-0685-8.

14.

CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial.

Dewan Y, Komolafe EO, Mejía-Mantilla JH, Perel P, Roberts I, Shakur H; CRASH-3 Collaborators.

Trials. 2012 Jun 21;13:87. doi: 10.1186/1745-6215-13-87.

15.

Tranexamic acid in trauma: how should we use it?

Roberts I.

J Thromb Haemost. 2015 Jun;13 Suppl 1:S195-9. doi: 10.1111/jth.12878. Review.

PMID:
26149023
16.

Antifibrinolytic drugs for acute traumatic injury.

Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators.

Cochrane Database Syst Rev. 2011 Jan 19;(1):CD004896. doi: 10.1002/14651858.CD004896.pub3. Review. Update in: Cochrane Database Syst Rev. 2012;12:CD004896.

PMID:
21249666
17.

Antifibrinolytic drugs for acute traumatic injury.

Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators.

Cochrane Database Syst Rev. 2012;12:CD004896. Review. Update in: Cochrane Database Syst Rev. 2015;5:CD004896.

PMID:
23418644
18.

The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial.

Shakur H, Elbourne D, Gülmezoglu M, Alfirevic Z, Ronsmans C, Allen E, Roberts I.

Trials. 2010 Apr 16;11:40. doi: 10.1186/1745-6215-11-40.

19.

Tranexamic acid use in severely injured civilian patients and the effects on outcomes: a prospective cohort study.

Cole E, Davenport R, Willett K, Brohi K.

Ann Surg. 2015 Feb;261(2):390-4. doi: 10.1097/SLA.0000000000000717.

PMID:
25412319
20.

Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial.

Guerriero C, Cairns J, Perel P, Shakur H, Roberts I; CRASH 2 trial collaborators.

PLoS One. 2011 May 3;6(5):e18987. doi: 10.1371/journal.pone.0018987.

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