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Results: 1 to 20 of 140

1.

PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome.

He X, Saji M, Radhakrishnan D, Romigh T, Ngeow J, Yu Q, Wang Y, Ringel MD, Eng C.

J Clin Endocrinol Metab. 2012 Nov;97(11):E2179-87. doi: 10.1210/jc.2012-1991. Epub 2012 Sep 7.

PMID:
22962422
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Utility of PTEN protein dosage in predicting for underlying germline PTEN mutations among patients presenting with thyroid cancer and Cowden-like phenotypes.

Ngeow J, He X, Mester JL, Lei J, Romigh T, Orloff MS, Milas M, Eng C.

J Clin Endocrinol Metab. 2012 Dec;97(12):E2320-7. doi: 10.1210/jc.2012-2944. Epub 2012 Oct 12.

PMID:
23066114
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53.

Ni Y, He X, Chen J, Moline J, Mester J, Orloff MS, Ringel MD, Eng C.

Hum Mol Genet. 2012 Jan 15;21(2):300-10. doi: 10.1093/hmg/ddr459. Epub 2011 Oct 6.

PMID:
21979946
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations.

Ngeow J, Mester J, Rybicki LA, Ni Y, Milas M, Eng C.

J Clin Endocrinol Metab. 2011 Dec;96(12):E2063-71. doi: 10.1210/jc.2011-1616. Epub 2011 Sep 28.

PMID:
21956414
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway.

Zhou XP, Waite KA, Pilarski R, Hampel H, Fernandez MJ, Bos C, Dasouki M, Feldman GL, Greenberg LA, Ivanovich J, Matloff E, Patterson A, Pierpont ME, Russo D, Nassif NT, Eng C.

Am J Hum Genet. 2003 Aug;73(2):404-11. Epub 2003 Jul 3.

PMID:
12844284
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome.

Bennett KL, Mester J, Eng C.

JAMA. 2010 Dec 22;304(24):2724-31. doi: 10.1001/jama.2010.1877.

PMID:
21177507
[PubMed - indexed for MEDLINE]
Free PMC Article
7.
8.

Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line.

Singh G, Odriozola L, Guan H, Kennedy CR, Chan AM.

BMC Cancer. 2011 Nov 21;11:490. doi: 10.1186/1471-2407-11-490.

PMID:
22103913
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1.

Bruni P, Boccia A, Baldassarre G, Trapasso F, Santoro M, Chiappetta G, Fusco A, Viglietto G.

Oncogene. 2000 Jun 29;19(28):3146-55.

PMID:
10918569
[PubMed - indexed for MEDLINE]
Free Article
10.

Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis.

Eng C.

Ann N Y Acad Sci. 2002 Jun;968:213-21. Review.

PMID:
12119278
[PubMed - indexed for MEDLINE]
11.

Immunohistochemical staining of thyroidectomy specimens for PTEN can aid in the identification of patients with Cowden syndrome.

Barletta JA, Bellizzi AM, Hornick JL.

Am J Surg Pathol. 2011 Oct;35(10):1505-11. doi: 10.1097/PAS.0b013e31822fbc7d.

PMID:
21921783
[PubMed - indexed for MEDLINE]
12.

A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer.

Tate G, Suzuki T, Endo Y, Mitsuya T.

Cancer Genet Cytogenet. 2008 Jul;184(1):67-71. doi: 10.1016/j.cancergencyto.2008.03.013.

PMID:
18558293
[PubMed - indexed for MEDLINE]
13.

Thyroid pathology in PTEN-hamartoma tumor syndrome: characteristic findings of a distinct entity.

Laury AR, Bongiovanni M, Tille JC, Kozakewich H, Nosé V.

Thyroid. 2011 Feb;21(2):135-44. doi: 10.1089/thy.2010.0226. Epub 2010 Dec 29.

PMID:
21190448
[PubMed - indexed for MEDLINE]
14.

Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.

Orloff MS, He X, Peterson C, Chen F, Chen JL, Mester JL, Eng C.

Am J Hum Genet. 2013 Jan 10;92(1):76-80. doi: 10.1016/j.ajhg.2012.10.021. Epub 2012 Dec 13.

PMID:
23246288
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes.

Ni Y, Zbuk KM, Sadler T, Patocs A, Lobo G, Edelman E, Platzer P, Orloff MS, Waite KA, Eng C.

Am J Hum Genet. 2008 Aug;83(2):261-8. doi: 10.1016/j.ajhg.2008.07.011.

PMID:
18678321
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53.

He X, Ni Y, Wang Y, Romigh T, Eng C.

Hum Mol Genet. 2011 Jan 1;20(1):80-9. doi: 10.1093/hmg/ddq434. Epub 2010 Oct 6.

PMID:
20926450
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.

Yeager N, Klein-Szanto A, Kimura S, Di Cristofano A.

Cancer Res. 2007 Feb 1;67(3):959-66.

PMID:
17283127
[PubMed - indexed for MEDLINE]
Free Article
18.

PTEN inhibits BMI1 function independently of its phosphatase activity.

Fan C, He L, Kapoor A, Rybak AP, De Melo J, Cutz JC, Tang D.

Mol Cancer. 2009 Nov 10;8:98. doi: 10.1186/1476-4598-8-98.

PMID:
19903340
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors.

Gimm O, Perren A, Weng LP, Marsh DJ, Yeh JJ, Ziebold U, Gil E, Hinze R, Delbridge L, Lees JA, Mutter GL, Robinson BG, Komminoth P, Dralle H, Eng C.

Am J Pathol. 2000 May;156(5):1693-700.

PMID:
10793080
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

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