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Results: 1 to 20 of 135

1.

Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells.

Yen WC, Fischer MM, Hynes M, Wu J, Kim E, Beviglia L, Yeung VP, Song X, Kapoun AM, Lewicki J, Gurney A, Simeone DM, Hoey T.

Clin Cancer Res. 2012 Oct 1;18(19):5374-86. doi: 10.1158/1078-0432.CCR-12-0736. Epub 2012 Sep 5.

PMID:
22952347
[PubMed - indexed for MEDLINE]
Free Article
2.

Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

Li JL, Sainson RC, Shi W, Leek R, Harrington LS, Preusser M, Biswas S, Turley H, Heikamp E, Hainfellner JA, Harris AL.

Cancer Res. 2007 Dec 1;67(23):11244-53.

PMID:
18056450
[PubMed - indexed for MEDLINE]
Free Article
3.

DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency.

Hoey T, Yen WC, Axelrod F, Basi J, Donigian L, Dylla S, Fitch-Bruhns M, Lazetic S, Park IK, Sato A, Satyal S, Wang X, Clarke MF, Lewicki J, Gurney A.

Cell Stem Cell. 2009 Aug 7;5(2):168-77. doi: 10.1016/j.stem.2009.05.019.

PMID:
19664991
[PubMed - indexed for MEDLINE]
Free Article
4.

DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

Li JL, Sainson RC, Oon CE, Turley H, Leek R, Sheldon H, Bridges E, Shi W, Snell C, Bowden ET, Wu H, Chowdhury PS, Russell AJ, Montgomery CP, Poulsom R, Harris AL.

Cancer Res. 2011 Sep 15;71(18):6073-83. doi: 10.1158/0008-5472.CAN-11-1704. Epub 2011 Jul 29.

PMID:
21803743
[PubMed - indexed for MEDLINE]
Free Article
5.

Delta-like ligand 4-notch blockade and tumor radiation response.

Liu SK, Bham SA, Fokas E, Beech J, Im J, Cho S, Harris AL, Muschel RJ.

J Natl Cancer Inst. 2011 Dec 7;103(23):1778-98. doi: 10.1093/jnci/djr419. Epub 2011 Oct 18.

PMID:
22010178
[PubMed - indexed for MEDLINE]
Free Article
6.

Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer.

Yabuuchi S, Pai SG, Campbell NR, de Wilde RF, De Oliveira E, Korangath P, Streppel MM, Rasheed ZA, Hidalgo M, Maitra A, Rajeshkumar NV.

Cancer Lett. 2013 Jul 10;335(1):41-51. doi: 10.1016/j.canlet.2013.01.054. Epub 2013 Feb 10.

PMID:
23402814
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Aberrant expression and association of VEGF and Dll4/Notch pathway molecules under hypoxia in patients with lung cancer.

Yu S, Sun J, Zhang J, Xu X, Li H, Shan B, Tian T, Wang H, Ma D, Ji C.

Histol Histopathol. 2013 Feb;28(2):277-84.

PMID:
23275310
[PubMed - indexed for MEDLINE]
8.

Insights into the regulation of tumor dormancy by angiogenesis in experimental tumors.

Indraccolo S.

Adv Exp Med Biol. 2013;734:37-52. doi: 10.1007/978-1-4614-1445-2_3.

PMID:
23143974
[PubMed - indexed for MEDLINE]
9.

Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations.

Fischer M, Yen WC, Kapoun AM, Wang M, O'Young G, Lewicki J, Gurney A, Hoey T.

Cancer Res. 2011 Mar 1;71(5):1520-5. doi: 10.1158/0008-5472.CAN-10-2817. Epub 2010 Dec 30.

PMID:
21193546
[PubMed - indexed for MEDLINE]
Free Article
10.

Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells.

Harrington LS, Sainson RC, Williams CK, Taylor JM, Shi W, Li JL, Harris AL.

Microvasc Res. 2008 Mar;75(2):144-54. Epub 2007 Jun 29.

PMID:
17692341
[PubMed - indexed for MEDLINE]
11.

Antibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in mice.

Li L, Hao X, Qin J, Tang W, He F, Smith A, Zhang M, Simeone DM, Qiao XT, Chen ZN, Lawrence TS, Xu L.

Gastroenterology. 2014 Apr;146(4):1108-18. doi: 10.1053/j.gastro.2013.12.035. Epub 2014 Jan 5.

PMID:
24397969
[PubMed - indexed for MEDLINE]
12.

Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.

Bruns CJ, Harbison MT, Davis DW, Portera CA, Tsan R, McConkey DJ, Evans DB, Abbruzzese JL, Hicklin DJ, Radinsky R.

Clin Cancer Res. 2000 May;6(5):1936-48.

PMID:
10815919
[PubMed - indexed for MEDLINE]
Free Article
13.

Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth.

Segarra M, Williams CK, Sierra Mde L, Bernardo M, McCormick PJ, Maric D, Regino C, Choyke P, Tosato G.

Blood. 2008 Sep 1;112(5):1904-11. doi: 10.1182/blood-2007-11-126045. Epub 2008 Jun 24.

PMID:
18577711
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Delta-like 4/Notch signaling and its therapeutic implications.

Yan M, Plowman GD.

Clin Cancer Res. 2007 Dec 15;13(24):7243-6. Review.

PMID:
18094402
[PubMed - indexed for MEDLINE]
Free Article
15.

Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer.

Mullendore ME, Koorstra JB, Li YM, Offerhaus GJ, Fan X, Henderson CM, Matsui W, Eberhart CG, Maitra A, Feldmann G.

Clin Cancer Res. 2009 Apr 1;15(7):2291-301. doi: 10.1158/1078-0432.CCR-08-2004. Epub 2009 Mar 3.

PMID:
19258443
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis.

Djokovic D, Trindade A, Gigante J, Badenes M, Silva L, Liu R, Li X, Gong M, Krasnoperov V, Gill PS, Duarte A.

BMC Cancer. 2010 Nov 23;10:641. doi: 10.1186/1471-2407-10-641.

PMID:
21092311
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function.

Williams CK, Li JL, Murga M, Harris AL, Tosato G.

Blood. 2006 Feb 1;107(3):931-9. Epub 2005 Oct 11.

PMID:
16219802
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts.

Bockhorn M, Tsuzuki Y, Xu L, Frilling A, Broelsch CE, Fukumura D.

Clin Cancer Res. 2003 Sep 15;9(11):4221-6.

PMID:
14519649
[PubMed - indexed for MEDLINE]
Free Article
19.

Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells.

Williams CK, Segarra M, Sierra Mde L, Sainson RC, Tosato G, Harris AL.

Cancer Res. 2008 Mar 15;68(6):1889-95. doi: 10.1158/0008-5472.CAN-07-2181.

PMID:
18339870
[PubMed - indexed for MEDLINE]
Free Article
20.

Feed-forward signaling by membrane-bound ligand receptor circuit: the case of NOTCH DELTA-like 4 ligand in endothelial cells.

Caolo V, van den Akker NM, Verbruggen S, Donners MM, Swennen G, Schulten H, Waltenberger J, Post MJ, Molin DG.

J Biol Chem. 2010 Dec 24;285(52):40681-9. doi: 10.1074/jbc.M110.176065. Epub 2010 Oct 19.

PMID:
20959466
[PubMed - indexed for MEDLINE]
Free PMC Article

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