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Results: 1 to 20 of 101

1.

In vivo selection of transplanted hepatocytes by pharmacological inhibition of fumarylacetoacetate hydrolase in wild-type mice.

Paulk NK, Wursthorn K, Haft A, Pelz C, Clarke G, Newell AH, Olson SB, Harding CO, Finegold MJ, Bateman RL, Witte JF, McClard R, Grompe M.

Mol Ther. 2012 Oct;20(10):1981-7. doi: 10.1038/mt.2012.154. Epub 2012 Aug 7.

PMID:
22871666
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.

Bateman RL, Ashworth J, Witte JF, Baker LJ, Bhanumoorthy P, Timm DE, Hurley TD, Grompe M, McClard RW.

Biochem J. 2007 Mar 1;402(2):251-60.

PMID:
17064256
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I.

Overturf K, Al-Dhalimy M, Tanguay R, Brantly M, Ou CN, Finegold M, Grompe M.

Nat Genet. 1996 Mar;12(3):266-73. Erratum in: Nat Genet 1996 Apr;12(4):458.

PMID:
8589717
[PubMed - indexed for MEDLINE]
4.

Hepatocytes from wild-type or heterozygous donors are equally effective in achieving successful therapeutic liver repopulation in murine phenylketonuria (PKU).

Hamman KJ, Winn SR, Harding CO.

Mol Genet Metab. 2011 Nov;104(3):235-40. doi: 10.1016/j.ymgme.2011.07.027. Epub 2011 Aug 4.

PMID:
21917493
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Ex vivo hepatic gene therapy of a mouse model of Hereditary Tyrosinemia Type I.

Overturf K, Al-Dhalimy M, Manning K, Ou CN, Finegold M, Grompe M.

Hum Gene Ther. 1998 Feb 10;9(3):295-304.

PMID:
9508047
[PubMed - indexed for MEDLINE]
6.

Complete rescue of lethal albino c14CoS mice by null mutation of 4-hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway.

Endo F, Kubo S, Awata H, Kiwaki K, Katoh H, Kanegae Y, Saito I, Miyazaki J, Yamamoto T, Jakobs C, Hattori S, Matsuda I.

J Biol Chem. 1997 Sep 26;272(39):24426-32.

PMID:
9305902
[PubMed - indexed for MEDLINE]
Free Article
7.

In vivo genetic selection of renal proximal tubules.

Held PK, Al-Dhalimy M, Willenbring H, Akkari Y, Jiang S, Torimaru Y, Olson S, Fleming WH, Finegold M, Grompe M.

Mol Ther. 2006 Jan;13(1):49-58. Epub 2005 Oct 10.

PMID:
16216560
[PubMed - indexed for MEDLINE]
8.

Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes.

Mignon A, Guidotti JE, Mitchell C, Fabre M, Wernet A, De La Coste A, Soubrane O, Gilgenkrantz H, Kahn A.

Nat Med. 1998 Oct;4(10):1185-8.

PMID:
9771754
[PubMed - indexed for MEDLINE]
9.

Messenger RNA as a source of transposase for sleeping beauty transposon-mediated correction of hereditary tyrosinemia type I.

Wilber A, Wangensteen KJ, Chen Y, Zhuo L, Frandsen JL, Bell JB, Chen ZJ, Ekker SC, McIvor RS, Wang X.

Mol Ther. 2007 Jul;15(7):1280-7. Epub 2007 Apr 17.

PMID:
17440442
[PubMed - indexed for MEDLINE]
10.

Aneuploidy as a mechanism for stress-induced liver adaptation.

Duncan AW, Hanlon Newell AE, Bi W, Finegold MJ, Olson SB, Beaudet AL, Grompe M.

J Clin Invest. 2012 Sep 4;122(9):3307-15. doi: 10.1172/JCI64026. Epub 2012 Aug 6.

PMID:
22863619
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Allogeneic bone marrow transplantation restores liver function in Fah-knockout mice.

Eggenhofer E, Popp FC, Renner P, Slowik P, Neuwinger A, Piso P, Geissler EK, Schlitt HJ, Dahlke MH.

Exp Hematol. 2008 Nov;36(11):1507-13. doi: 10.1016/j.exphem.2008.05.010. Epub 2008 Aug 19.

PMID:
18715687
[PubMed - indexed for MEDLINE]
12.

Kidneys of mice with hereditary tyrosinemia type I are extremely sensitive to cytotoxicity.

Jacobs SM, van Beurden DH, Klomp LW, Berger R, van den Berg IE.

Pediatr Res. 2006 Mar;59(3):365-70.

PMID:
16492973
[PubMed - indexed for MEDLINE]
13.

Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I.

Overturf K, al-Dhalimy M, Ou CN, Finegold M, Tanguay R, Lieber A, Kay M, Grompe M.

Hum Gene Ther. 1997 Mar 20;8(5):513-21.

PMID:
9095403
[PubMed - indexed for MEDLINE]
14.

Renal proximal tubular cells acquire resistance to cell death stimuli in mice with hereditary tyrosinemia type 1.

Luijerink MC, van Beurden EA, Malingré HE, Jacobs SM, Grompe M, Klomp LW, Berger R, van den Berg IE.

Kidney Int. 2004 Sep;66(3):990-1000.

PMID:
15327392
[PubMed - indexed for MEDLINE]
15.

Transplanted bone marrow regenerates liver by cell fusion.

Vassilopoulos G, Wang PR, Russell DW.

Nature. 2003 Apr 24;422(6934):901-4. Epub 2003 Mar 30.

PMID:
12665833
[PubMed - indexed for MEDLINE]
16.

Murine embryonic stem cell-derived hepatocytes correct metabolic liver disease after serial liver repopulation.

He ZY, Deng L, Li YF, Xiang D, Hu JK, Chen YX, Wang MJ, Chen F, Liu CC, Li WL, Zi XY, Wu X, Li GP, Wangensteen KJ, Hu YP, Wang X.

Int J Biochem Cell Biol. 2012 Apr;44(4):648-58. doi: 10.1016/j.biocel.2012.01.002. Epub 2012 Jan 10.

PMID:
22249028
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Xeno-repopulation of Fah -/- Nod/Scid mice livers by human hepatocytes.

Su B, Liu C, Xiang D, Zhang H, Yuan S, Wang M, Chen F, Zhu H, He Z, Wang X, Hu Y.

Sci China Life Sci. 2011 Mar;54(3):227-34. doi: 10.1007/s11427-011-4140-7. Epub 2011 Mar 16. Erratum in: Sci China Life Sci. 2011 Jun;54(6):588.

PMID:
21416322
[PubMed - indexed for MEDLINE]
18.

Ploidy reductions in murine fusion-derived hepatocytes.

Duncan AW, Hickey RD, Paulk NK, Culberson AJ, Olson SB, Finegold MJ, Grompe M.

PLoS Genet. 2009 Feb;5(2):e1000385. doi: 10.1371/journal.pgen.1000385. Epub 2009 Feb 20.

PMID:
19229314
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells.

Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Schöler HR, Cantz T.

PLoS Biol. 2011 Jul;9(7):e1001099. doi: 10.1371/journal.pbio.1001099. Epub 2011 Jul 12.

PMID:
21765802
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

High volume naked DNA tail-vein injection restores liver function in Fah-knock out mice.

Eggenhofer E, Doenecke A, Renner P, Slowik P, Piso P, Geissler EK, Schlitt HJ, Dahlke MH, Popp FC.

J Gastroenterol Hepatol. 2010 May;25(5):1002-8. doi: 10.1111/j.1440-1746.2009.06156.x.

PMID:
20546455
[PubMed - indexed for MEDLINE]
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