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Results: 1 to 20 of 76

1.

Alzheimer's-related peptide amyloid-β plays a conserved role in angiogenesis.

Cameron DJ, Galvin C, Alkam T, Sidhu H, Ellison J, Luna S, Ethell DW.

PLoS One. 2012;7(7):e39598. doi: 10.1371/journal.pone.0039598. Epub 2012 Jul 9.

PMID:
22792182
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

An amyloid-notch hypothesis for Alzheimer's disease.

Ethell DW.

Neuroscientist. 2010 Dec;16(6):614-7. doi: 10.1177/1073858410366162. Epub 2010 Jun 30. Review.

PMID:
20592273
[PubMed - indexed for MEDLINE]
3.

Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies.

Evin G, Sernee MF, Masters CL.

CNS Drugs. 2006;20(5):351-72. Review.

PMID:
16696577
[PubMed - indexed for MEDLINE]
4.

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

Phiel CJ, Wilson CA, Lee VM, Klein PS.

Nature. 2003 May 22;423(6938):435-9.

PMID:
12761548
[PubMed - indexed for MEDLINE]
5.

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.

Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T.

Am J Pathol. 2007 Feb;170(2):680-92.

PMID:
17255335
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.

Nakayama K, Nagase H, Koh CS, Ohkawara T.

Cell Mol Neurobiol. 2011 Aug;31(6):887-900. doi: 10.1007/s10571-011-9688-z. Epub 2011 Apr 23. Review.

PMID:
21516353
[PubMed - indexed for MEDLINE]
7.

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.

Borgegård T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J, Jureus A, Ridderstad-Wollberg A, Wollberg P, Stockling K, Karlström H, Malmberg A, Lund J, Arvidsson PI, De Strooper B, Lendahl U, Lundkvist J.

J Neurosci. 2012 Nov 28;32(48):17297-305. doi: 10.1523/JNEUROSCI.1451-12.2012.

PMID:
23197721
[PubMed - indexed for MEDLINE]
Free Article
8.

Alzheimer's disease and Notch signaling.

Woo HN, Park JS, Gwon AR, Arumugam TV, Jo DG.

Biochem Biophys Res Commun. 2009 Dec 25;390(4):1093-7. doi: 10.1016/j.bbrc.2009.10.093. Epub 2009 Oct 22. Review.

PMID:
19853579
[PubMed - indexed for MEDLINE]
9.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
[PubMed - indexed for MEDLINE]
10.

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.

Pamrén A, Wanngren J, Tjernberg LO, Winblad B, Bhat R, Näslund J, Karlström H.

J Biol Chem. 2011 Sep 9;286(36):31153-8. doi: 10.1074/jbc.C111.235267. Epub 2011 Jul 18.

PMID:
21768095
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H.

J Biol Chem. 2010 Mar 19;285(12):8527-36. doi: 10.1074/jbc.M109.055590. Epub 2010 Jan 27.

PMID:
20106965
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Abeta peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis.

Donnini S, Solito R, Cetti E, Corti F, Giachetti A, Carra S, Beltrame M, Cotelli F, Ziche M.

FASEB J. 2010 Jul;24(7):2385-95. doi: 10.1096/fj.09-146456. Epub 2010 Mar 5.

PMID:
20207941
[PubMed - indexed for MEDLINE]
Free Article
13.

Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.

Albright CF, Dockens RC, Meredith JE Jr, Olson RE, Slemmon R, Lentz KA, Wang JS, Denton RR, Pilcher G, Rhyne PW, Raybon JJ, Barten DM, Burton C, Toyn JH, Sankaranarayanan S, Polson C, Guss V, White R, Simutis F, Sanderson T, Gillman KW, Starrett JE Jr, Bronson J, Sverdlov O, Huang SP, Castaneda L, Feldman H, Coric V, Zaczek R, Macor JE, Houston J, Berman RM, Tong G.

J Pharmacol Exp Ther. 2013 Mar;344(3):686-95. doi: 10.1124/jpet.112.199356. Epub 2012 Dec 28.

PMID:
23275065
[PubMed - indexed for MEDLINE]
Free Article
14.

γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.

Hedskog L, Petersen CA, Svensson AI, Welander H, Tjernberg LO, Karlström H, Ankarcrona M.

J Cell Mol Med. 2011 Oct;15(10):2150-63. doi: 10.1111/j.1582-4934.2010.01208.x.

PMID:
21054783
[PubMed - indexed for MEDLINE]
15.

APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis.

Crews L, Rockenstein E, Masliah E.

Brain Struct Funct. 2010 Mar;214(2-3):111-26. doi: 10.1007/s00429-009-0232-6. Epub 2009 Nov 29. Review.

PMID:
20091183
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Regulation of β cleavage of amyloid precursor protein.

Wang JF, Lu R, Wang YZ.

Neurosci Bull. 2010 Oct;26(5):417-27. doi: 10.1007/s12264-010-0515-1. Review.

PMID:
20882069
[PubMed - indexed for MEDLINE]
17.

Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment.

Li T, Huang Y, Jin S, Ye L, Rong N, Yang X, Ding Y, Cheng Z, Zhang J, Wan Z, Harrison DC, Hussain I, Hall A, Lee DH, Lau LF, Matsuoka Y.

J Neurochem. 2012 Apr;121(2):277-86. doi: 10.1111/j.1471-4159.2011.07560.x. Epub 2012 Mar 13.

PMID:
22035227
[PubMed - indexed for MEDLINE]
18.

Processing of amyloid precursor protein as a biochemical link between atherosclerosis and Alzheimer's disease.

Jans DM, Martinet W, Van De Parre TJ, Herman AG, Bult H, Kockx MM, De Meyer GR.

Cardiovasc Hematol Disord Drug Targets. 2006 Mar;6(1):21-34. Review.

PMID:
16724933
[PubMed - indexed for MEDLINE]
19.

Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.

Ho A, Liu X, Südhof TC.

J Neurosci. 2008 Dec 31;28(53):14392-400. doi: 10.1523/JNEUROSCI.2481-08.2008.

PMID:
19118172
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

PMID:
19671883
[PubMed - indexed for MEDLINE]
Free Article
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