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Items: 1 to 20 of 168

1.

Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.

Ammosova T, Platonov M, Yedavalli VR, Obukhov Y, Gordeuk VR, Jeang KT, Kovalskyy D, Nekhai S.

PLoS One. 2012;7(6):e39481. doi: 10.1371/journal.pone.0039481. Epub 2012 Jun 29.

2.

1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.

Ammosova T, Platonov M, Ivanov A, Kont YS, Kumari N, Kehn-Hall K, Jerebtsova M, Kulkarni AA, Uren A, Kovalskyy D, Nekhai S.

Br J Pharmacol. 2014 Nov;171(22):5059-75. doi: 10.1111/bph.12863.

3.

Expression of a protein phosphatase 1 inhibitor, cdNIPP1, increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcription.

Ammosova T, Yedavalli VR, Niu X, Jerebtsova M, Van Eynde A, Beullens M, Bollen M, Jeang KT, Nekhai S.

J Biol Chem. 2011 Feb 4;286(5):3798-804. doi: 10.1074/jbc.M110.196493. Epub 2010 Nov 22.

4.

Identification of novel inhibitors of human immunodeficiency virus type 1 replication by in silico screening targeting cyclin T1/Tat interaction.

Hamasaki T, Okamoto M, Baba M.

Antimicrob Agents Chemother. 2013 Mar;57(3):1323-31. doi: 10.1128/AAC.01711-12. Epub 2012 Dec 28.

5.

Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.

Ammosova T, Washington K, Debebe Z, Brady J, Nekhai S.

Retrovirology. 2005 Jul 27;2:47.

6.

Interactor-mediated nuclear translocation and retention of protein phosphatase-1.

Lesage B, Beullens M, Nuytten M, Van Eynde A, Keppens S, Himpens B, Bollen M.

J Biol Chem. 2004 Dec 31;279(53):55978-84. Epub 2004 Oct 22.

7.

Regulation of HIV-1 transcription by protein phosphatase 1.

Nekhai S, Jerebtsova M, Jackson A, Southerland W.

Curr HIV Res. 2007 Jan;5(1):3-9. Review.

PMID:
17266553
8.

PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation.

Kim YM, Watanabe T, Allen PB, Kim YM, Lee SJ, Greengard P, Nairn AC, Kwon YG.

J Biol Chem. 2003 Apr 18;278(16):13819-28. Epub 2003 Feb 6.

9.

Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA.

Lalonde MS, Lobritz MA, Ratcliff A, Chamanian M, Athanassiou Z, Tyagi M, Wong J, Robinson JA, Karn J, Varani G, Arts EJ.

PLoS Pathog. 2011 May;7(5):e1002038. doi: 10.1371/journal.ppat.1002038. Epub 2011 May 19.

10.

Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.

Choy MS, Hieke M, Kumar GS, Lewis GR, Gonzalez-DeWhitt KR, Kessler RP, Stein BJ, Hessenberger M, Nairn AC, Peti W, Page R.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4097-102. doi: 10.1073/pnas.1317395111. Epub 2014 Mar 3.

11.

[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].

Wang J, Liu XY.

Yao Xue Xue Bao. 2009 Dec;44(12):1343-7. Review. Chinese.

PMID:
21351466
12.

Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.

Ammosova T, Jerebtsova M, Beullens M, Lesage B, Jackson A, Kashanchi F, Southerland W, Gordeuk VR, Bollen M, Nekhai S.

J Biol Chem. 2005 Oct 28;280(43):36364-71. Epub 2005 Aug 29.

13.

Nuclear protein phosphatase-1 regulates HIV-1 transcription.

Ammosova T, Jerebtsova M, Beullens M, Voloshin Y, Ray PE, Kumar A, Bollen M, Nekhai S.

J Biol Chem. 2003 Aug 22;278(34):32189-94. Epub 2003 Jun 4.

14.

The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme.

O'Connell N, Nichols SR, Heroes E, Beullens M, Bollen M, Peti W, Page R.

Structure. 2012 Oct 10;20(10):1746-56. doi: 10.1016/j.str.2012.08.003. Epub 2012 Aug 30.

15.

Inhibitors of HIV-1 gene expression and transcription.

Baba M.

Curr Top Med Chem. 2004;4(9):871-82. Review.

PMID:
15134546
16.

Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1.

Wakula P, Beullens M, Ceulemans H, Stalmans W, Bollen M.

J Biol Chem. 2003 May 23;278(21):18817-23. Epub 2003 Mar 25.

17.

Importance of a surface hydrophobic pocket on protein phosphatase-1 catalytic subunit in recognizing cellular regulators.

Gibbons JA, Weiser DC, Shenolikar S.

J Biol Chem. 2005 Apr 22;280(16):15903-11. Epub 2005 Feb 9.

18.
19.

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication.

Hamy F, Felder ER, Heizmann G, Lazdins J, Aboul-ela F, Varani G, Karn J, Klimkait T.

Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3548-53.

20.

Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription.

Wang Q, Young TM, Mathews MB, Pe'ery T.

J Mol Biol. 2007 Mar 30;367(3):630-46. Epub 2007 Jan 12.

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