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Items: 1 to 20 of 102

1.

7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove.

Ibarra-Soza JM, Morris AA, Jayalath P, Peacock H, Conrad WE, Donald MB, Kurth MJ, Beal PA.

Org Biomol Chem. 2012 Aug 28;10(32):6491-7. doi: 10.1039/c2ob25647a. Epub 2012 Jul 5.

2.

N(2)-Modified 2-aminopurine ribonucleosides as minor-groove-modulating adenosine replacements in duplex RNA.

Peacock H, Maydanovych O, Beal PA.

Org Lett. 2010 Mar 5;12(5):1044-7. doi: 10.1021/ol100019r.

3.

Modification of the siRNA passenger strand by 5-nitroindole dramatically reduces its off-target effects.

Zhang J, Zheng J, Lu C, Du Q, Liang Z, Xi Z.

Chembiochem. 2012 Sep 3;13(13):1940-5. doi: 10.1002/cbic.201200349. Epub 2012 Aug 7.

PMID:
22887813
4.

Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.

Ghanty U, Fostvedt E, Valenzuela R, Beal PA, Burrows CJ.

J Am Chem Soc. 2012 Oct 24;134(42):17643-52. doi: 10.1021/ja307102g. Epub 2012 Oct 11.

5.

RNA major groove modifications improve siRNA stability and biological activity.

Terrazas M, Kool ET.

Nucleic Acids Res. 2009 Feb;37(2):346-53. doi: 10.1093/nar/gkn958. Epub 2008 Nov 28.

6.

siRNA function in RNAi: a chemical modification analysis.

Chiu YL, Rana TM.

RNA. 2003 Sep;9(9):1034-48.

7.

Click modification of RNA at adenosine: structure and reactivity of 7-ethynyl- and 7-triazolyl-8-aza-7-deazaadenosine in RNA.

Phelps KJ, Ibarra-Soza JM, Tran K, Fisher AJ, Beal PA.

ACS Chem Biol. 2014 Aug 15;9(8):1780-7. doi: 10.1021/cb500270x. Epub 2014 Jun 16.

8.

Preparation of zwitterionic ribonucleoside phosphoramidites for solid-phase siRNA synthesis.

Smicius R, Engels JW.

J Org Chem. 2008 Jul 4;73(13):4994-5002. doi: 10.1021/jo800451m. Epub 2008 Jun 4.

PMID:
18522425
9.

Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.

Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M.

Nucleic Acids Res. 2007;35(19):6424-38. Epub 2007 Sep 18.

10.

Hoogsteen vs. Watson-Crick base pairing: incorporation of 2-substituted adenine- and 7-deazaadenine 2'-deoxy-beta-D-ribonucleosides into oligonucleotides.

Ramzaeva N, Michalek E, Kazimierczuk Z, Seela F, Rosemeyer H.

Chem Biodivers. 2007 Dec;4(12):2725-44.

PMID:
18081083
11.

Synthesis of 2'-O-guanidinopropyl-modified nucleoside phosphoramidites and their incorporation into siRNAs targeting hepatitis B virus.

Brzezinska J, D'Onofrio J, Buff MC, Hean J, Ely A, Marimani M, Arbuthnot P, Engels JW.

Bioorg Med Chem. 2012 Feb 15;20(4):1594-606. doi: 10.1016/j.bmc.2011.12.024. Epub 2011 Dec 21.

PMID:
22264759
12.

Intracellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect.

Takahashi M, Nagai C, Hatakeyama H, Minakawa N, Harashima H, Matsuda A.

Nucleic Acids Res. 2012 Jul;40(12):5787-93. doi: 10.1093/nar/gks204. Epub 2012 Mar 12.

13.

Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors.

Gillerman I, Fischer B.

J Med Chem. 2011 Jan 13;54(1):107-21. doi: 10.1021/jm101286g. Epub 2010 Dec 7.

PMID:
21138280
14.

Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs.

Peacock H, Fostvedt E, Beal PA.

ACS Chem Biol. 2010 Dec 17;5(12):1115-24. doi: 10.1021/cb100245u. Epub 2010 Oct 7.

15.

Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases.

Hernández AR, Peterson LW, Kool ET.

ACS Chem Biol. 2012 Aug 17;7(8):1454-61. doi: 10.1021/cb300174c. Epub 2012 Jun 12.

16.

Short interfering RNA guide strand modifiers from computational screening.

Onizuka K, Harrison JG, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Ly D, Lam W, Mac S, Tantillo DJ, Beal PA.

J Am Chem Soc. 2013 Nov 13;135(45):17069-77. doi: 10.1021/ja4079754. Epub 2013 Nov 5.

17.

Synthesis, gene silencing, and molecular modeling studies of 4'-C-aminomethyl-2'-O-methyl modified small interfering RNAs.

Gore KR, Nawale GN, Harikrishna S, Chittoor VG, Pandey SK, Höbartner C, Patankar S, Pradeepkumar PI.

J Org Chem. 2012 Apr 6;77(7):3233-45. doi: 10.1021/jo202666m. Epub 2012 Mar 16.

PMID:
22372696
18.

Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.

Mutisya D, Selvam C, Lunstad BD, Pallan PS, Haas A, Leake D, Egli M, Rozners E.

Nucleic Acids Res. 2014 Jun;42(10):6542-51. doi: 10.1093/nar/gku235. Epub 2014 May 9. Erratum in: Nucleic Acids Res. 2014;42(16):10870.

19.
20.

Syntheses of 4'-thioribonucleosides and thermodynamic stability and crystal structure of RNA oligomers with incorporated 4'-thiocytosine.

Haeberli P, Berger I, Pallan PS, Egli M.

Nucleic Acids Res. 2005 Jul 18;33(13):3965-75. Print 2005.

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