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Items: 1 to 20 of 99

1.

Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.

Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C.

Nat Chem Biol. 2012 Aug;8(8):725-30. doi: 10.1038/nchembio.1008. Epub 2012 Jun 24.

2.

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.

Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C.

J Clin Invest. 2004 Oct;114(8):1158-64.

3.

Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.

Wilczynski A, Wang XS, Joseph CG, Xiang Z, Bauzo RM, Scott JW, Sorensen NB, Shaw AM, Millard WJ, Richards NG, Haskell-Luevano C.

J Med Chem. 2004 Apr 22;47(9):2194-207.

PMID:
15084118
4.

Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH.

Chapman KL, Kinsella GK, Cox A, Donnelly D, Findlay JB.

J Mol Biol. 2010 Aug 20;401(3):433-50. doi: 10.1016/j.jmb.2010.06.028. Epub 2010 Jun 19.

5.
7.

Activation of MAPK by inverse agonists in six naturally occurring constitutively active mutant human melanocortin-4 receptors.

Mo XL, Tao YX.

Biochim Biophys Acta. 2013 Dec;1832(12):1939-48. doi: 10.1016/j.bbadis.2013.06.006. Epub 2013 Jun 18.

8.

Constitutive traffic of melanocortin-4 receptor in Neuro2A cells and immortalized hypothalamic neurons.

Mohammad S, Baldini G, Granell S, Narducci P, Martelli AM, Baldini G.

J Biol Chem. 2007 Feb 16;282(7):4963-74. Epub 2006 Dec 12.

9.

Constitutive activity of neural melanocortin receptors.

Tao YX, Huang H, Wang ZQ, Yang F, Williams JN, Nikiforovich GV.

Methods Enzymol. 2010;484:267-79. doi: 10.1016/B978-0-12-381298-8.00014-9.

PMID:
21036237
10.

Molecular basis of melanocortin-4 receptor for AGRP inverse agonism.

Chen M, Celik A, Georgeson KE, Harmon CM, Yang Y.

Regul Pept. 2006 Sep 11;136(1-3):40-9. Epub 2006 Jul 3.

PMID:
16820227
11.
12.

Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.

Xiang Z, Litherland SA, Sorensen NB, Proneth B, Wood MS, Shaw AM, Millard WJ, Haskell-Luevano C.

Biochemistry. 2006 Jun 13;45(23):7277-88.

PMID:
16752916
13.

Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism.

Proneth B, Xiang Z, Pogozheva ID, Litherland SA, Gorbatyuk OS, Shaw AM, Millard WJ, Mosberg HI, Haskell-Luevano C.

Chem Biol Drug Des. 2006 Mar;67(3):215-29.

PMID:
16611215
14.

Exposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize.

Granell S, Molden BM, Baldini G.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4733-42. doi: 10.1073/pnas.1219808110. Epub 2013 Nov 18.

15.

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.

Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD.

Nature. 2015 Apr 2;520(7545):94-8. doi: 10.1038/nature14051. Epub 2015 Jan 19.

16.

Molecular determination of agouti-related protein binding to human melanocortin-4 receptor.

Yang Y, Chen M, Lai Y, Gantz I, Yagmurlu A, Georgeson KE, Harmon CM.

Mol Pharmacol. 2003 Jul;64(1):94-103.

17.

Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).

Singh A, Dirain ML, Wilczynski A, Chen C, Gosnell BA, Levine AS, Edison AS, Haskell-Luevano C.

ACS Chem Neurosci. 2014 Oct 15;5(10):1020-31. doi: 10.1021/cn5000953. Epub 2014 Aug 26.

18.

Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to α-melanocyte-stimulating hormone (α-MSH).

McDaniel FK, Molden BM, Mohammad S, Baldini G, McPike L, Narducci P, Granell S, Baldini G.

J Biol Chem. 2012 Jun 22;287(26):21873-90. doi: 10.1074/jbc.M112.346890. Epub 2012 Apr 27.

19.

Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax).

Sánchez E, Rubio VC, Thompson D, Metz J, Flik G, Millhauser GL, Cerdá-Reverter JM.

Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1293-306. doi: 10.1152/ajpregu.90948.2008. Epub 2009 Feb 18.

20.

Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein.

Oosterom J, Garner KM, den Dekker WK, Nijenhuis WA, Gispen WH, Burbach JP, Barsh GS, Adan RA.

J Biol Chem. 2001 Jan 12;276(2):931-6.

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