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Results: 1 to 20 of 166

Similar articles for PubMed (Select 22688056)

1.

Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.

Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM.

Am J Pathol. 2012 Aug;181(2):616-25. doi: 10.1016/j.ajpath.2012.04.020. Epub 2012 Jun 9.

2.

Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.

Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG.

J Biol Chem. 2010 Sep 3;285(36):27737-44. doi: 10.1074/jbc.M110.117960. Epub 2010 Jul 1.

3.

Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions.

Higuchi M, Iwata N, Saido TC.

Biochim Biophys Acta. 2005 Aug 1;1751(1):60-7. Epub 2005 Mar 17. Review.

PMID:
16054018
4.

The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo.

Nikkel AL, Martino B, Markosyan S, Brederson JD, Medeiros R, Moeller A, Bitner RS.

Neuropharmacology. 2012 Sep;63(4):606-12. doi: 10.1016/j.neuropharm.2012.05.011. Epub 2012 May 18.

PMID:
22613839
5.

Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice.

Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, Kakuda N, Horikoshi-Sakuraba Y, Tan J, Town T.

J Biol Chem. 2012 Feb 24;287(9):6912-27. doi: 10.1074/jbc.M111.294025. Epub 2012 Jan 4.

6.

Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5.

Lopes JP, Oliveira CR, Agostinho P.

Aging Cell. 2010 Feb;9(1):64-77. doi: 10.1111/j.1474-9726.2009.00536.x. Epub 2009 Nov 6.

7.

Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.

Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E.

J Neurosci Res. 2006 May 15;83(7):1252-61.

PMID:
16511867
8.

Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.

Chu J, Li JG, Praticò D.

PLoS One. 2013 Aug 7;8(8):e70991. doi: 10.1371/journal.pone.0070991. eCollection 2013.

9.

Hypoxia increases Aβ-induced tau phosphorylation by calpain and promotes behavioral consequences in AD transgenic mice.

Gao L, Tian S, Gao H, Xu Y.

J Mol Neurosci. 2013 Sep;51(1):138-47. doi: 10.1007/s12031-013-9966-y. Epub 2013 Jan 24.

PMID:
23345083
10.

Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice.

Barroso E, del Valle J, Porquet D, Vieira Santos AM, Salvadó L, Rodríguez-Rodríguez R, Gutiérrez P, Anglada-Huguet M, Alberch J, Camins A, Palomer X, Pallàs M, Michalik L, Wahli W, Vázquez-Carrera M.

Biochim Biophys Acta. 2013 Aug;1832(8):1241-8. doi: 10.1016/j.bbadis.2013.03.006. Epub 2013 Mar 16.

11.
12.

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease.

Shukla V, Skuntz S, Pant HC.

Arch Med Res. 2012 Nov;43(8):655-62. doi: 10.1016/j.arcmed.2012.10.015. Epub 2012 Nov 7. Review.

13.

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.

McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S.

J Biol Chem. 2007 Sep 7;282(36):26326-34. Epub 2007 Jul 6.

14.

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

Wen Y, Planel E, Herman M, Figueroa HY, Wang L, Liu L, Lau LF, Yu WH, Duff KE.

J Neurosci. 2008 Mar 5;28(10):2624-32. doi: 10.1523/JNEUROSCI.5245-07.2008.

15.

The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons.

Sinjoanu RC, Kleinschmidt S, Bitner RS, Brioni JD, Moeller A, Ferreira A.

Neurochem Int. 2008 Sep;53(3-4):79-88. doi: 10.1016/j.neuint.2008.06.003. Epub 2008 Jun 12.

16.

Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.

Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF.

J Neurosci. 2005 Dec 14;25(50):11542-52.

17.

Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1).

Giusti-Rodríguez P, Gao J, Gräff J, Rei D, Soda T, Tsai LH.

J Neurosci. 2011 Nov 2;31(44):15751-6. doi: 10.1523/JNEUROSCI.3588-11.2011.

18.

Beneficial effect of antibodies against β- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice.

Rabinovich-Nikitin I, Rakover IS, Becker M, Solomon B.

PLoS One. 2012;7(10):e46650. doi: 10.1371/journal.pone.0046650. Epub 2012 Oct 10.

19.

Immunomodulation of AβPP processing alleviates amyloid-β-related pathology in Alzheimer's disease transgenic mice.

Arbel-Ornath M, Becker M, Rabinovich-Toidman P, Gartner M, Solomon B.

J Alzheimers Dis. 2010;22(2):469-82. doi: 10.3233/JAD-2010-100753.

PMID:
20847413
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