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Results: 1 to 20 of 244

1.

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin.

Yang D, Li T, Liu Z, Arbez N, Yan J, Moran TH, Ross CA, Smith WW.

Neurobiol Dis. 2012 Sep;47(3):385-92. doi: 10.1016/j.nbd.2012.05.020. Epub 2012 Jun 2.

PMID:
22668778
[PubMed - indexed for MEDLINE]
2.

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.

Liu Z, Hamamichi S, Lee BD, Yang D, Ray A, Caldwell GA, Caldwell KA, Dawson TM, Smith WW, Dawson VL.

Hum Mol Genet. 2011 Oct 15;20(20):3933-42. doi: 10.1093/hmg/ddr312. Epub 2011 Jul 18.

PMID:
21768216
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity.

Heo HY, Park JM, Kim CH, Han BS, Kim KS, Seol W.

Exp Cell Res. 2010 Feb 15;316(4):649-56. doi: 10.1016/j.yexcr.2009.09.014. Epub 2009 Sep 19.

PMID:
19769964
[PubMed - indexed for MEDLINE]
4.

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein.

Niu J, Yu M, Wang C, Xu Z.

J Neurochem. 2012 Aug;122(3):650-8. doi: 10.1111/j.1471-4159.2012.07809.x. Epub 2012 Jun 22.

PMID:
22639965
[PubMed - indexed for MEDLINE]
5.

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.

Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez-Gutiérrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars DW, De Strooper B, Verstreken P.

Neuron. 2012 Sep 20;75(6):1008-21. doi: 10.1016/j.neuron.2012.08.022.

PMID:
22998870
[PubMed - indexed for MEDLINE]
Free Article
6.

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

Wang L, Xie C, Greggio E, Parisiadou L, Shim H, Sun L, Chandran J, Lin X, Lai C, Yang WJ, Moore DJ, Dawson TM, Dawson VL, Chiosis G, Cookson MR, Cai H.

J Neurosci. 2008 Mar 26;28(13):3384-91. doi: 10.1523/JNEUROSCI.0185-08.2008.

PMID:
18367605
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.

Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, Oota E, Lu B.

EMBO J. 2008 Sep 17;27(18):2432-43. doi: 10.1038/emboj.2008.163. Epub 2008 Aug 14.

PMID:
18701920
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A Drosophila model for LRRK2-linked parkinsonism.

Liu Z, Wang X, Yu Y, Li X, Wang T, Jiang H, Ren Q, Jiao Y, Sawa A, Moran T, Ross CA, Montell C, Smith WW.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2693-8. doi: 10.1073/pnas.0708452105. Epub 2008 Feb 7.

PMID:
18258746
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

Lee SB, Kim W, Lee S, Chung J.

Biochem Biophys Res Commun. 2007 Jun 29;358(2):534-9. Epub 2007 May 4.

PMID:
17498648
[PubMed - indexed for MEDLINE]
10.

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.

Kanao T, Venderova K, Park DS, Unterman T, Lu B, Imai Y.

Hum Mol Genet. 2010 Oct 1;19(19):3747-58. doi: 10.1093/hmg/ddq289. Epub 2010 Jul 12.

PMID:
20624856
[PubMed - indexed for MEDLINE]
Free Article
11.

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake.

Zhou H, Huang C, Tong J, Hong WC, Liu YJ, Xia XG.

Int J Biol Sci. 2011;7(6):753-61. Epub 2011 Jun 9.

PMID:
21698001
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Kinase activity of mutant LRRK2 mediates neuronal toxicity.

Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA.

Nat Neurosci. 2006 Oct;9(10):1231-3. Epub 2006 Sep 17.

PMID:
16980962
[PubMed - indexed for MEDLINE]
13.

Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation.

Greene ID, Mastaglia F, Meloni BP, West KA, Chieng J, Mitchell CJ, Gai WP, Boulos S.

J Neurosci Res. 2014 Apr;92(4):506-16. doi: 10.1002/jnr.23331. Epub 2013 Dec 24.

PMID:
24375786
[PubMed - indexed for MEDLINE]
14.

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.

MacLeod DA, Rhinn H, Kuwahara T, Zolin A, Di Paolo G, McCabe BD, Marder KS, Honig LS, Clark LN, Small SA, Abeliovich A.

Neuron. 2013 Feb 6;77(3):425-39. doi: 10.1016/j.neuron.2012.11.033. Erratum in: Neuron. 2013 Mar 6;77(5):994. MacCabe, Brian D [corrected to McCabe, Brian D].

PMID:
23395371
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells.

Ortiz-Ortiz MA, Morán JM, Ruiz-Mesa LM, Niso-Santano M, Bravo-SanPedro JM, Gómez-Sánchez R, González-Polo RA, Fuentes JM.

Neurosci Lett. 2010 Jan 4;468(2):120-4. doi: 10.1016/j.neulet.2009.10.081. Epub 2009 Oct 30.

PMID:
19879924
[PubMed - indexed for MEDLINE]
16.

Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2.

Tong Y, Shen J.

Biochem Soc Trans. 2012 Oct;40(5):1042-6. Review.

PMID:
22988862
[PubMed - indexed for MEDLINE]
17.

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.

Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H, Wilson-Delfosse AL, Chen SG.

Hum Mol Genet. 2013 Jan 15;22(2):328-44. doi: 10.1093/hmg/dds431. Epub 2012 Oct 12.

PMID:
23065705
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.

Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schüle B, Dolmetsch RE, Langston W, Palmer TD, Pera RR.

Cell Stem Cell. 2011 Mar 4;8(3):267-80. doi: 10.1016/j.stem.2011.01.013.

PMID:
21362567
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Identification of chemicals to inhibit the kinase activity of leucine-rich repeat kinase 2 (LRRK2), a Parkinson's disease-associated protein.

Yun H, Heo HY, Kim HH, DooKim N, Seol W.

Bioorg Med Chem Lett. 2011 May 15;21(10):2953-7. doi: 10.1016/j.bmcl.2011.03.061. Epub 2011 Mar 21.

PMID:
21474311
[PubMed - indexed for MEDLINE]
20.

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14622-7. doi: 10.1073/pnas.0906334106. Epub 2009 Aug 10.

PMID:
19667187
[PubMed - indexed for MEDLINE]
Free PMC Article
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