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Results: 1 to 20 of 161

1.

The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer.

Roh JL, Ko JH, Moon SJ, Ryu CH, Choi JY, Koch WM.

Cancer Lett. 2012 Dec 1;325(1):35-41. doi: 10.1016/j.canlet.2012.05.020. Epub 2012 May 22.

PMID:
22634494
[PubMed - indexed for MEDLINE]
2.

p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma.

Roh JL, Kang SK, Minn I, Califano JA, Sidransky D, Koch WM.

Oral Oncol. 2011 Jan;47(1):8-15. doi: 10.1016/j.oraloncology.2010.10.011. Epub 2010 Dec 15.

PMID:
21109480
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Drug resistance to inhibitors of the human double minute-2 E3 ligase is mediated by point mutations of p53, but can be overcome with the p53 targeting agent RITA.

Jones RJ, Bjorklund CC, Baladandayuthapani V, Kuhn DJ, Orlowski RZ.

Mol Cancer Ther. 2012 Oct;11(10):2243-53. doi: 10.1158/1535-7163.MCT-12-0135. Epub 2012 Aug 28.

PMID:
22933706
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer.

Roh JL, Kim EH, Park HB, Park JY.

Cell Death Dis. 2013 Dec 12;4:e956. doi: 10.1038/cddis.2013.488.

PMID:
24336076
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells.

Fraser M, Chan SL, Chan SS, Fiscus RR, Tsang BK.

Oncogene. 2006 Apr 6;25(15):2203-12.

PMID:
16288207
[PubMed - indexed for MEDLINE]
6.

Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.

Saha MN, Jiang H, Chang H.

Cancer Biol Ther. 2010 Sep 15;10(6):567-78. Epub 2010 Oct 1.

PMID:
20595817
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Cisplatin-induced growth arrest of head and neck cancer cells correlates with increased expression of p16 and p53.

Yip HT, Chopra R, Chakrabarti R, Veena MS, Ramamurthy B, Srivatsan ES, Wang MB.

Arch Otolaryngol Head Neck Surg. 2006 Mar;132(3):317-26.

PMID:
16549753
[PubMed - indexed for MEDLINE]
8.

Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization.

Ndoye A, Dolivet G, Høgset A, Leroux A, Fifre A, Erbacher P, Berg K, Behr JP, Guillemin F, Merlin JL.

Mol Ther. 2006 Jun;13(6):1156-62. Epub 2006 Mar 27.

PMID:
16564229
[PubMed - indexed for MEDLINE]
9.

Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway.

Koster R, Timmer-Bosscha H, Bischoff R, Gietema JA, de Jong S.

Cell Death Dis. 2011 Apr 21;2:e148. doi: 10.1038/cddis.2011.33.

PMID:
21509038
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

RITA enhances chemosensivity of pre-B ALL cells to doxorubicin by inducing p53-dependent apoptosis.

Kazemi A, Safa M, Shahbazi A.

Hematology. 2011 Jul;16(4):225-31. doi: 10.1179/102453311X12953015767536. Erratum in: Hematology. 2011 Sep;16(5):324.

PMID:
21756539
[PubMed - indexed for MEDLINE]
11.

Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation.

Shukla S, Gupta S.

Free Radic Biol Med. 2008 May 15;44(10):1833-45. doi: 10.1016/j.freeradbiomed.2008.02.007. Epub 2008 Feb 26.

PMID:
18342637
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice.

Zheng T, Meng X, Wang J, Chen X, Yin D, Liang Y, Song X, Pan S, Jiang H, Liu L.

J Cell Biochem. 2010 Sep 1;111(1):218-28. doi: 10.1002/jcb.22691.

PMID:
20506484
[PubMed - indexed for MEDLINE]
13.

Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy.

Azmi AS, Philip PA, Aboukameel A, Wang Z, Banerjee S, Zafar SF, Goustin AS, Almhanna K, Yang D, Sarkar FH, Mohammad RM.

Curr Cancer Drug Targets. 2010 May;10(3):319-31.

PMID:
20370686
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA.

Zhao CY, Grinkevich VV, Nikulenkov F, Bao W, Selivanova G.

Cell Cycle. 2010 May;9(9):1847-55. Epub 2010 May 15.

PMID:
20436301
[PubMed - indexed for MEDLINE]
Free Article
15.

EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression.

Selvendiran K, Tong L, Vishwanath S, Bratasz A, Trigg NJ, Kutala VK, Hideg K, Kuppusamy P.

J Biol Chem. 2007 Sep 28;282(39):28609-18. Epub 2007 Aug 7.

PMID:
17684018
[PubMed - indexed for MEDLINE]
Free Article
16.

Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed.

Li Q, Kawamura K, Yamanaka M, Okamoto S, Yang S, Yamauchi S, Fukamachi T, Kobayashi H, Tada Y, Takiguchi Y, Tatsumi K, Shimada H, Hiroshima K, Tagawa M.

Cancer Gene Ther. 2012 Mar;19(3):218-28. doi: 10.1038/cgt.2011.86. Epub 2012 Jan 6.

PMID:
22223137
[PubMed - indexed for MEDLINE]
17.

MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53.

Enge M, Bao W, Hedström E, Jackson SP, Moumen A, Selivanova G.

Cancer Cell. 2009 Mar 3;15(3):171-83. doi: 10.1016/j.ccr.2009.01.019. Erratum in: Cancer Cell. 2009 Jul 7;16(1):79.

PMID:
19249676
[PubMed - indexed for MEDLINE]
Free Article
18.

Diesel exhaust particles induce apoptosis via p53 and Mdm2 in J774A.1 macrophage cell line.

Yun YP, Lee JY, Ahn EK, Lee KH, Yoon HK, Lim Y.

Toxicol In Vitro. 2009 Feb;23(1):21-8. doi: 10.1016/j.tiv.2008.09.018. Epub 2008 Oct 2.

PMID:
18940243
[PubMed - indexed for MEDLINE]
19.

Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice.

Wang YJ, Jeng JH, Chen RJ, Tseng H, Chen LC, Liang YC, Lin CH, Chen CH, Chu JS, Ho WL, Ho YS.

Mol Carcinog. 2002 Aug;34(4):199-210.

PMID:
12203371
[PubMed - indexed for MEDLINE]
20.

MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 function.

Azmi AS, Aboukameel A, Banerjee S, Wang Z, Mohammad M, Wu J, Wang S, Yang D, Philip PA, Sarkar FH, Mohammad RM.

Eur J Cancer. 2010 Apr;46(6):1122-31. doi: 10.1016/j.ejca.2010.01.015. Epub 2010 Feb 13.

PMID:
20156675
[PubMed - indexed for MEDLINE]

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