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Items: 1 to 20 of 143

1.

ER stress is involved in T17M rhodopsin-induced retinal degeneration.

Kunte MM, Choudhury S, Manheim JF, Shinde VM, Miura M, Chiodo VA, Hauswirth WW, Gorbatyuk OS, Gorbatyuk MS.

Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3792-800. doi: 10.1167/iovs.11-9235.

2.

ER stress in retinal degeneration in S334ter Rho rats.

Shinde VM, Sizova OS, Lin JH, LaVail MM, Gorbatyuk MS.

PLoS One. 2012;7(3):e33266. doi: 10.1371/journal.pone.0033266. Epub 2012 Mar 14.

3.

Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration.

Nashine S, Bhootada Y, Lewin AS, Gorbatyuk M.

PLoS One. 2013 Apr 30;8(4):e63205. doi: 10.1371/journal.pone.0063205. Print 2013.

4.

Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration.

Choudhury S, Bhootada Y, Gorbatyuk O, Gorbatyuk M.

Cell Death Dis. 2013 Mar 7;4:e528. doi: 10.1038/cddis.2013.34.

5.

Increased sensitivity to light-induced damage in a mouse model of autosomal dominant retinal disease.

White DA, Fritz JJ, Hauswirth WW, Kaushal S, Lewin AS.

Invest Ophthalmol Vis Sci. 2007 May;48(5):1942-51. Erratum in: Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3436. Fritz, Jason J [added].

PMID:
17460245
6.

Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response.

Choudhury S, Nashine S, Bhootada Y, Kunte MM, Gorbatyuk O, Lewin AS, Gorbatyuk M.

Adv Exp Med Biol. 2014;801:455-62. doi: 10.1007/978-1-4614-3209-8_58.

7.

Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors.

Sizova OS, Shinde VM, Lenox AR, Gorbatyuk MS.

Cell Signal. 2014 Apr;26(4):665-72. doi: 10.1016/j.cellsig.2013.12.008. Epub 2013 Dec 27.

8.

Targeting Caspase-12 to Preserve Vision in Mice With Inherited Retinal Degeneration.

Bhootada Y, Choudhury S, Gully C, Gorbatyuk M.

Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4725-33. doi: 10.1167/iovs.15-16924.

9.

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78.

Gorbatyuk MS, Knox T, LaVail MM, Gorbatyuk OS, Noorwez SM, Hauswirth WW, Lin JH, Muzyczka N, Lewin AS.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5961-6. doi: 10.1073/pnas.0911991107. Epub 2010 Mar 15.

10.

Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration.

Kroeger H, Messah C, Ahern K, Gee J, Joseph V, Matthes MT, Yasumura D, Gorbatyuk MS, Chiang WC, LaVail MM, Lin JH.

Invest Ophthalmol Vis Sci. 2012 Nov 9;53(12):7590-9. doi: 10.1167/iovs.12-10221.

11.

Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol.

Li C, Wang L, Huang K, Zheng L.

Invest Ophthalmol Vis Sci. 2012 May 31;53(6):3241-9. doi: 10.1167/iovs.11-8406.

PMID:
22491413
12.

Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations.

Aleman TS, Cideciyan AV, Sumaroka A, Windsor EA, Herrera W, White DA, Kaushal S, Naidu A, Roman AJ, Schwartz SB, Stone EM, Jacobson SG.

Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1580-90. doi: 10.1167/iovs.07-1110.

13.

Retinitis pigmentosa‑associated rhodopsin mutant T17M induces endoplasmic reticulum (ER) stress and sensitizes cells to ER stress-induced cell death.

Jiang H, Xiong S, Xia X.

Mol Med Rep. 2014 May;9(5):1737-42. doi: 10.3892/mmr.2014.1987. Epub 2014 Feb 26.

PMID:
24573320
14.

Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa.

Bhootada Y, Kotla P, Zolotukhin S, Gorbatyuk O, Bebok Z, Athar M, Gorbatyuk M.

PLoS One. 2016 May 4;11(5):e0154779. doi: 10.1371/journal.pone.0154779. eCollection 2016.

15.

An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina.

Rana T, Shinde VM, Starr CR, Kruglov AA, Boitet ER, Kotla P, Zolotukhin S, Gross AK, Gorbatyuk MS.

Cell Death Dis. 2014 Dec 18;5:e1578. doi: 10.1038/cddis.2014.539.

16.

Ablation of Chop Transiently Enhances Photoreceptor Survival but Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin.

Chiang WC, Joseph V, Yasumura D, Matthes MT, Lewin AS, Gorbatyuk MS, Ahern K, LaVail MM, Lin JH.

Adv Exp Med Biol. 2016;854:185-91. doi: 10.1007/978-3-319-17121-0_25.

17.

Testicular hyperthermia induces Unfolded Protein Response signaling activation in spermatocyte.

Kim JH, Park SJ, Kim TS, Park HJ, Park J, Kim BK, Kim GR, Kim JM, Huang SM, Chae JI, Park CK, Lee DS.

Biochem Biophys Res Commun. 2013 May 17;434(4):861-6. doi: 10.1016/j.bbrc.2013.04.032. Epub 2013 Apr 20.

PMID:
23611781
18.

Modulation of angiogenesis by genetic manipulation of ATF4 in mouse model of oxygen-induced retinopathy [corrected].

Wang X, Wang G, Kunte M, Shinde V, Gorbatyuk M.

Invest Ophthalmol Vis Sci. 2013 Sep 3;54(9):5995-6002. doi: 10.1167/iovs.13-12117. Erratum in: Invest Ophthalmol Vis Sci. 2014 Mar;55(3):1310.

19.

Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response.

Manni S, Brancalion A, Tubi LQ, Colpo A, Pavan L, Cabrelle A, Ave E, Zaffino F, Di Maira G, Ruzzene M, Adami F, Zambello R, Pitari MR, Tassone P, Pinna LA, Gurrieri C, Semenzato G, Piazza F.

Clin Cancer Res. 2012 Apr 1;18(7):1888-900. doi: 10.1158/1078-0432.CCR-11-1789. Epub 2012 Feb 20.

20.

Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa.

Marsili S, Genini S, Sudharsan R, Gingrich J, Aguirre GD, Beltran WA.

PLoS One. 2015 Feb 19;10(2):e0115723. doi: 10.1371/journal.pone.0115723. eCollection 2015.

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