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Results: 1 to 20 of 96

1.

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.

Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T.

Am J Respir Cell Mol Biol. 2012 Oct;47(4):445-53. doi: 10.1165/rcmb.2011-0332OC. Epub 2012 May 10.

PMID:
22582175
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema.

Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay MA, Zemskov EA, White R, Block NL, Schally AV.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2084-9. doi: 10.1073/pnas.1121075109. Epub 2012 Jan 23.

PMID:
22308467
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition.

Xiong C, Yang G, Kumar S, Aggarwal S, Leustik M, Snead C, Hamacher J, Fischer B, Umapathy NS, Hossain H, Wendel A, Catravas JD, Verin AD, Fulton D, Black SM, Chakraborty T, Lucas R.

Vascul Pharmacol. 2010 May-Jun;52(5-6):207-13. doi: 10.1016/j.vph.2009.12.010. Epub 2010 Jan 13.

PMID:
20074664
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.

Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Matthay MA, Schally AV, Lucas R.

Front Physiol. 2014 Jul 15;5:259. doi: 10.3389/fphys.2014.00259. eCollection 2014.

PMID:
25076911
[PubMed]
Free PMC Article
5.

Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction.

Peng J, He F, Zhang C, Deng X, Yin F.

J Neuroinflammation. 2011 Apr 8;8:28. doi: 10.1186/1742-2094-8-28.

PMID:
21473788
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Sirolimus-FKBP12.6 impairs endothelial barrier function through protein kinase C-α activation and disruption of the p120-vascular endothelial cadherin interaction.

Habib A, Karmali V, Polavarapu R, Akahori H, Cheng Q, Pachura K, Kolodgie FD, Finn AV.

Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2425-31. doi: 10.1161/ATVBAHA.113.301659. Epub 2013 Jul 25.

PMID:
23887639
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity.

Vandenbroucke St Amant E, Tauseef M, Vogel SM, Gao XP, Mehta D, Komarova YA, Malik AB.

Circ Res. 2012 Aug 31;111(6):739-49. doi: 10.1161/CIRCRESAHA.112.269654. Epub 2012 Jul 12.

PMID:
22798526
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling.

Joshi AD, Dimitropoulou C, Thangjam G, Snead C, Feldman S, Barabutis N, Fulton D, Hou Y, Kumar S, Patel V, Gorshkov B, Verin AD, Black SM, Catravas JD.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):170-9. doi: 10.1165/rcmb.2012-0496OC.

PMID:
23972231
[PubMed - indexed for MEDLINE]
9.

Role of platelet-activating factor in pneumolysin-induced acute lung injury.

Witzenrath M, Gutbier B, Owen JS, Schmeck B, Mitchell TJ, Mayer K, Thomas MJ, Ishii S, Rosseau S, Suttorp N, Schütte H.

Crit Care Med. 2007 Jul;35(7):1756-62.

PMID:
17522574
[PubMed - indexed for MEDLINE]
10.

Hypoxia-reoxygenation-induced endothelial barrier failure: role of RhoA, Rac1 and myosin light chain kinase.

Aslam M, Schluter KD, Rohrbach S, Rafiq A, Nazli S, Piper HM, Noll T, Schulz R, Gündüz D.

J Physiol. 2013 Jan 15;591(Pt 2):461-73. doi: 10.1113/jphysiol.2012.237834. Epub 2012 Oct 22.

PMID:
23090948
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A novel approach to prevent endothelial hyperpermeability: the Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway.

Bubik MF, Willer EA, Bihari P, Jürgenliemk G, Ammer H, Krombach F, Zahler S, Vollmar AM, Fürst R.

J Mol Cell Cardiol. 2012 Jan;52(1):196-205. doi: 10.1016/j.yjmcc.2011.10.020. Epub 2011 Oct 31.

PMID:
22085704
[PubMed - indexed for MEDLINE]
12.

Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells.

van der Heijden M, van Nieuw Amerongen GP, van Bezu J, Paul MA, Groeneveld AB, van Hinsbergh VW.

PLoS One. 2011;6(8):e23448. doi: 10.1371/journal.pone.0023448. Epub 2011 Aug 15.

PMID:
21858121
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Insulin stabilizes microvascular endothelial barrier function via phosphatidylinositol 3-kinase/Akt-mediated Rac1 activation.

Gündüz D, Thom J, Hussain I, Lopez D, Härtel FV, Erdogan A, Grebe M, Sedding D, Piper HM, Tillmanns H, Noll T, Aslam M.

Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1237-45. doi: 10.1161/ATVBAHA.110.203901. Epub 2010 Mar 25.

PMID:
20339116
[PubMed - indexed for MEDLINE]
Free Article
14.

RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction.

Venkatesh D, Fredette N, Rostama B, Tang Y, Vary CP, Liaw L, Urs S.

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):876-82. doi: 10.1161/ATVBAHA.110.221945. Epub 2011 Jan 27.

PMID:
21273559
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.

Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD, Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ.

Front Immunol. 2013 Aug 7;4:228. doi: 10.3389/fimmu.2013.00228. eCollection 2013.

PMID:
23966993
[PubMed]
Free PMC Article
16.

Bone marrow-derived progenitor cells prevent thrombin-induced increase in lung vascular permeability.

Zhao YD, Ohkawara H, Vogel SM, Malik AB, Zhao YY.

Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L36-44. doi: 10.1152/ajplung.00064.2009. Epub 2009 Oct 30.

PMID:
19880506
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Vasodilator-stimulated phosphoprotein deficiency potentiates PAR-1-induced increase in endothelial permeability in mouse lungs.

Profirovic J, Han J, Andreeva AV, Neamu RF, Pavlovic S, Vogel SM, Walter U, Voyno-Yasenetskaya TA.

J Cell Physiol. 2011 May;226(5):1255-64. doi: 10.1002/jcp.22453.

PMID:
20945373
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Phosphorylation of caveolin-1 regulates oxidant-induced pulmonary vascular permeability via paracellular and transcellular pathways.

Sun Y, Hu G, Zhang X, Minshall RD.

Circ Res. 2009 Sep 25;105(7):676-85, 15 p following 685. doi: 10.1161/CIRCRESAHA.109.201673. Epub 2009 Aug 27.

PMID:
19713536
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia.

Rubins JB, Charboneau D, Paton JC, Mitchell TJ, Andrew PW, Janoff EN.

J Clin Invest. 1995 Jan;95(1):142-50.

PMID:
7814608
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC.

PLoS Pathog. 2010 Nov 11;6(11):e1001191. doi: 10.1371/journal.ppat.1001191.

PMID:
21085613
[PubMed - indexed for MEDLINE]
Free PMC Article

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