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Results: 1 to 20 of 133

1.

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.

Ratovitski T, Chighladze E, Arbez N, Boronina T, Herbrich S, Cole RN, Ross CA.

Cell Cycle. 2012 May 15;11(10):2006-21. doi: 10.4161/cc.20423. Epub 2012 May 15.

PMID:
22580459
[PubMed - indexed for MEDLINE]
Free PMC Article
2.
3.

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

Wang H, Lim PJ, Karbowski M, Monteiro MJ.

Hum Mol Genet. 2009 Feb 15;18(4):737-52. doi: 10.1093/hmg/ddn404. Epub 2008 Nov 27.

PMID:
19039036
[PubMed - indexed for MEDLINE]
Free PMC Article
4.
5.

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.

Caron NS, Desmond CR, Xia J, Truant R.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14610-5. doi: 10.1073/pnas.1301342110. Epub 2013 Jul 29.

PMID:
23898200
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.

Bao J, Sharp AH, Wagster MV, Becher M, Schilling G, Ross CA, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 1996 May 14;93(10):5037-42.

PMID:
8643525
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein.

Nucifora LG, Burke KA, Feng X, Arbez N, Zhu S, Miller J, Yang G, Ratovitski T, Delannoy M, Muchowski PJ, Finkbeiner S, Legleiter J, Ross CA, Poirier MA.

J Biol Chem. 2012 May 4;287(19):16017-28. doi: 10.1074/jbc.M111.252577. Epub 2012 Mar 20.

PMID:
22433867
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

BAG-1 associates with the polyglutamine-expanded huntingtin aggregates.

Jana NR, Nukina N.

Neurosci Lett. 2005 Apr 22;378(3):171-5. Epub 2005 Jan 6.

PMID:
15781153
[PubMed - indexed for MEDLINE]
9.

Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.

Goswami A, Dikshit P, Mishra A, Mulherkar S, Nukina N, Jana NR.

Biochem Biophys Res Commun. 2006 Mar 31;342(1):184-90. Epub 2006 Feb 3.

PMID:
16472774
[PubMed - indexed for MEDLINE]
10.

Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.

Huang CC, Faber PW, Persichetti F, Mittal V, Vonsattel JP, MacDonald ME, Gusella JF.

Somat Cell Mol Genet. 1998 Jul;24(4):217-33.

PMID:
10410676
[PubMed - indexed for MEDLINE]
11.
12.

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins.

Reijonen S, Putkonen N, Nørremølle A, Lindholm D, Korhonen L.

Exp Cell Res. 2008 Mar 10;314(5):950-60. doi: 10.1016/j.yexcr.2007.12.025. Epub 2008 Jan 14.

PMID:
18255062
[PubMed - indexed for MEDLINE]
13.

Huntingtin-protein interactions and the pathogenesis of Huntington's disease.

Li SH, Li XJ.

Trends Genet. 2004 Mar;20(3):146-54. Review.

PMID:
15036808
[PubMed - indexed for MEDLINE]
14.

A huntingtin-associated protein enriched in brain with implications for pathology.

Li XJ, Li SH, Sharp AH, Nucifora FC Jr, Schilling G, Lanahan A, Worley P, Snyder SH, Ross CA.

Nature. 1995 Nov 23;378(6555):398-402.

PMID:
7477378
[PubMed - indexed for MEDLINE]
15.

Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease.

Truant R, Atwal RS, Burtnik A.

Prog Neurobiol. 2007 Nov;83(4):211-27. Epub 2007 Jan 22. Review.

PMID:
17240517
[PubMed - indexed for MEDLINE]
16.

Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions.

Davranche A, Aviolat H, Zeder-Lutz G, Busso D, Altschuh D, Trottier Y, Klein FA.

Hum Mol Genet. 2011 Jul 15;20(14):2795-806. doi: 10.1093/hmg/ddr178. Epub 2011 Apr 25.

PMID:
21518730
[PubMed - indexed for MEDLINE]
Free Article
17.

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.

Seong IS, Ivanova E, Lee JM, Choo YS, Fossale E, Anderson M, Gusella JF, Laramie JM, Myers RH, Lesort M, MacDonald ME.

Hum Mol Genet. 2005 Oct 1;14(19):2871-80. Epub 2005 Aug 22.

PMID:
16115812
[PubMed - indexed for MEDLINE]
Free Article
18.

Molecular aspects of Huntington's disease.

Walling HW, Baldassare JJ, Westfall TC.

J Neurosci Res. 1998 Nov 1;54(3):301-8. Review.

PMID:
9819135
[PubMed - indexed for MEDLINE]
19.

Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA).

Jiang YJ, Che MX, Yuan JQ, Xie YY, Yan XZ, Hu HY.

J Biol Chem. 2011 Jul 15;286(28):25236-45. doi: 10.1074/jbc.M110.216333. Epub 2011 May 12.

PMID:
21566141
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.

Truant R, Atwal R, Burtnik A.

Biochem Cell Biol. 2006 Dec;84(6):912-7. Review.

PMID:
17215878
[PubMed - indexed for MEDLINE]

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