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Results: 1 to 20 of 136

Similar articles for PubMed (Select 22537414)

1.

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia.

Tamayev R, D'Adamio L.

Mol Neurodegener. 2012 Apr 26;7:19. doi: 10.1186/1750-1326-7-19.

2.

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.

Tamayev R, Matsuda S, Arancio O, D'Adamio L.

EMBO Mol Med. 2012 Mar;4(3):171-9. doi: 10.1002/emmm.201100195. Epub 2012 Jan 23.

3.

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.

Tamayev R, Akpan N, Arancio O, Troy CM, D'Adamio L.

Mol Neurodegener. 2012 Dec 10;7:60. doi: 10.1186/1750-1326-7-60.

4.

Increased AβPP processing in familial Danish dementia patients.

Matsuda S, Tamayev R, D'Adamio L.

J Alzheimers Dis. 2011;27(2):385-91. doi: 10.3233/JAD-2011-110785.

5.

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.

Tamayev R, Matsuda S, Giliberto L, Arancio O, D'Adamio L.

EMBO J. 2011 May 17;30(12):2501-9. doi: 10.1038/emboj.2011.161.

6.

An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.

Lombino F, Biundo F, Tamayev R, Arancio O, D'Adamio L.

PLoS One. 2013;8(2):e57120. doi: 10.1371/journal.pone.0057120. Epub 2013 Feb 22.

7.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

8.

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.

Eur J Neurosci. 2013 Jun;37(12):1962-9. doi: 10.1111/ejn.12235.

PMID:
23773065
9.
10.

Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.

Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.

J Neurosci Res. 2003 Nov 1;74(3):386-92.

PMID:
14598315
11.

BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.

Matsuda S, Giliberto L, Matsuda Y, McGowan EM, D'Adamio L.

J Neurosci. 2008 Aug 27;28(35):8668-76. doi: 10.1523/JNEUROSCI.2094-08.2008.

12.

Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.

Guo Q, Li H, Cole AL, Hur JY, Li Y, Zheng H.

PLoS One. 2013 Nov 20;8(11):e80706. doi: 10.1371/journal.pone.0080706. eCollection 2013.

13.

BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.

Matsuda S, Matsuda Y, D'Adamio L.

J Biol Chem. 2009 Jun 5;284(23):15815-25. doi: 10.1074/jbc.M109.006403. Epub 2009 Apr 14.

14.

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits.

Tamayev R, Matsuda S, Fà M, Arancio O, D'Adamio L.

Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20822-7. doi: 10.1073/pnas.1011689107. Epub 2010 Nov 22.

15.

Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.

Cook JJ, Wildsmith KR, Gilberto DB, Holahan MA, Kinney GG, Mathers PD, Michener MS, Price EA, Shearman MS, Simon AJ, Wang JX, Wu G, Yarasheski KE, Bateman RJ.

J Neurosci. 2010 May 12;30(19):6743-50. doi: 10.1523/JNEUROSCI.1381-10.2010.

16.

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF.

Eur J Neurosci. 2006 Jan;23(1):251-60.

PMID:
16420434
17.

Measuring APP carboxy-terminal fragments.

Esposito LA.

Methods Mol Biol. 2011;670:71-84. doi: 10.1007/978-1-60761-744-0_6.

PMID:
20967584
18.

Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.

Abramowski D, Wiederhold KH, Furrer U, Jaton AL, Neuenschwander A, Runser MJ, Danner S, Reichwald J, Ammaturo D, Staab D, Stoeckli M, Rueeger H, Neumann U, Staufenbiel M.

J Pharmacol Exp Ther. 2008 Nov;327(2):411-24. doi: 10.1124/jpet.108.140327. Epub 2008 Aug 7.

19.

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.

Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.

Neurobiol Dis. 2005 Nov;20(2):625-37. Epub 2005 Jun 3.

PMID:
15936948
20.

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J.

J Neurosci. 2005 Jul 20;25(29):6755-64.

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