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Items: 1 to 20 of 341


Gefitinib radiosensitizes stem-like glioma cells: inhibition of epidermal growth factor receptor-Akt-DNA-PK signaling, accompanied by inhibition of DNA double-strand break repair.

Kang KB, Zhu C, Wong YL, Gao Q, Ty A, Wong MC.

Int J Radiat Oncol Biol Phys. 2012 May 1;83(1):e43-52. doi: 10.1016/j.ijrobp.2011.11.037.


EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts.

Geoerger B, Gaspar N, Opolon P, Morizet J, Devanz P, Lecluse Y, Valent A, Lacroix L, Grill J, Vassal G.

Int J Cancer. 2008 Jul 1;123(1):209-16. doi: 10.1002/ijc.23488.


Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.

Toulany M, Kehlbach R, Florczak U, Sak A, Wang S, Chen J, Lobrich M, Rodemann HP.

Mol Cancer Ther. 2008 Jul;7(7):1772-81. doi: 10.1158/1535-7163.MCT-07-2200.


[Effect and mechanism of gefitinib inhibition on non-small cell lung cancer radiosensitivity of HCC827 and H358 cell lines].

Gao Z, Zhuang L, Chen Y.

Zhongguo Fei Ai Za Zhi. 2012 Jun;15(6):324-31. doi: 10.3779/j.issn.1009-3419.2012.06.02. Chinese.


[Effect of gefitinib on radiosensitivity of gastric cancer cell lines].

Cao WG, Ma T, Li JF, Li H, Ji YB, Chen XH, Liu BY, Jin YN.

Ai Zheng. 2007 Dec;26(12):1330-5. Chinese.


[Effection and mechanism of radiosensitivity of non-small cell lung cancer cell line H358 following gefitinib treatment].

Deng J, Zhuang L, Chen Y.

Zhongguo Fei Ai Za Zhi. 2011 Nov;14(11):841-7. doi: 10.3779/j.issn.1009-3419.2011.11.02. Chinese.


Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repair capacity.

Tanaka T, Munshi A, Brooks C, Liu J, Hobbs ML, Meyn RE.

Clin Cancer Res. 2008 Feb 15;14(4):1266-73. doi: 10.1158/1078-0432.CCR-07-1606.


Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors.

Griffero F, Daga A, Marubbi D, Capra MC, Melotti A, Pattarozzi A, Gatti M, Bajetto A, Porcile C, Barbieri F, Favoni RE, Lo Casto M, Zona G, Spaziante R, Florio T, Corte G.

J Biol Chem. 2009 Mar 13;284(11):7138-48. doi: 10.1074/jbc.M807111200. Epub 2009 Jan 14.


Treatment schedule is of importance when gefitinib is combined with irradiation of glioma and endothelial cells in vitro.

Andersson U, Johansson D, Behnam-Motlagh P, Johansson M, Malmer B.

Acta Oncol. 2007;46(7):951-60.


Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.

Toulany M, Kasten-Pisula U, Brammer I, Wang S, Chen J, Dittmann K, Baumann M, Dikomey E, Rodemann HP.

Clin Cancer Res. 2006 Jul 1;12(13):4119-26.


Delayed cell death associated with mitotic catastrophe in γ-irradiated stem-like glioma cells.

Firat E, Gaedicke S, Tsurumi C, Esser N, Weyerbrock A, Niedermann G.

Radiat Oncol. 2011 Jun 10;6:71. doi: 10.1186/1748-717X-6-71.


Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting.

Matar P, Rojo F, Cassia R, Moreno-Bueno G, Di Cosimo S, Tabernero J, Guzmán M, Rodriguez S, Arribas J, Palacios J, Baselga J.

Clin Cancer Res. 2004 Oct 1;10(19):6487-501.


Cyclopamine increases the radiosensitivity of human pancreatic cancer cells by regulating the DNA repair signal pathway through an epidermal growth factor receptor‑dependent pathway.

Wu XY, Che J, Sun KK, Shen XJ, Yang D, Zhong N, Zhao H.

Mol Med Rep. 2013 Oct;8(4):979-83. doi: 10.3892/mmr.2013.1605. Epub 2013 Jul 30.


The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents.

Lin MZ, Marzec KA, Martin JL, Baxter RC.

Oncogene. 2014 Jan 2;33(1):85-96. doi: 10.1038/onc.2012.538. Epub 2012 Nov 26.


Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice.

Ponnala S, Veeravalli KK, Chetty C, Dinh DH, Rao JS.

PLoS One. 2011;6(10):e26191. doi: 10.1371/journal.pone.0026191. Epub 2011 Oct 14.


Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells.

Ohta T, Ohmichi M, Shibuya T, Takahashi T, Tsutsumi S, Takahashi K, Kurachi H.

Cancer Biol Ther. 2012 Apr;13(6):408-16. doi: 10.4161/cbt.19292. Epub 2012 Apr 1.


Radiosensitizing effects of gefitinib at different administration times in vitro.

Zhuang HQ, Sun J, Yuan ZY, Wang J, Zhao LJ, Wang P, Ren XB, Wang CL.

Cancer Sci. 2009 Aug;100(8):1520-5. doi: 10.1111/j.1349-7006.2009.01190.x. Epub 2009 May 4.


K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs.

Minjgee M, Toulany M, Kehlbach R, Giehl K, Rodemann HP.

Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):1506-14. doi: 10.1016/j.ijrobp.2011.05.057. Epub 2011 Oct 8.


Inhibition of PI3 kinases enhances the sensitivity of non-small cell lung cancer cells to ionizing radiation.

Zhang T, Cui GB, Zhang J, Zhang F, Zhou YA, Jiang T, Li XF.

Oncol Rep. 2010 Dec;24(6):1683-9.

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