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Results: 1 to 20 of 102

1.

Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI.

Gallagher JJ, Zhang X, Ziomek GJ, Jacobs RE, Bearer EL.

Neuroimage. 2012 Apr 15;60(3):1856-66. doi: 10.1016/j.neuroimage.2012.01.132. Epub 2012 Feb 10.

PMID:
22500926
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Decreased axonal transport rates in the Tg2576 APP transgenic mouse: improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRI.

Wang FH, Appelkvist P, Klason T, Gissberg O, Bogstedt A, Eliason K, Martinsson S, Briem S, Andersson A, Visser SA, Ivarsson M, Lindberg M, Agerman K, Sandin J.

Eur J Neurosci. 2012 Nov;36(9):3165-72. doi: 10.1111/j.1460-9568.2012.08258.x. Epub 2012 Sep 10.

PMID:
22958226
[PubMed - indexed for MEDLINE]
3.

Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects.

Rodrigues EM, Weissmiller AM, Goldstein LS.

Hum Mol Genet. 2012 Nov 1;21(21):4587-601. doi: 10.1093/hmg/dds297. Epub 2012 Jul 27.

PMID:
22843498
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.

Lazarov O, Lee M, Peterson DA, Sisodia SS.

J Neurosci. 2002 Nov 15;22(22):9785-93.

PMID:
12427834
[PubMed - indexed for MEDLINE]
Free Article
5.

Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.

Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS.

Hum Mol Genet. 2008 Nov 15;17(22):3474-86. doi: 10.1093/hmg/ddn240. Epub 2008 Aug 11.

PMID:
18694898
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

In vivo imaging of axonal transport using MRI: aging and Alzheimer's disease.

Minoshima S, Cross D.

Eur J Nucl Med Mol Imaging. 2008 Mar;35 Suppl 1:S89-92. doi: 10.1007/s00259-007-0707-8. Review.

PMID:
18204931
[PubMed - indexed for MEDLINE]
7.

Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo.

Gunawardena S, Yang G, Goldstein LS.

Hum Mol Genet. 2013 Oct 1;22(19):3828-43. doi: 10.1093/hmg/ddt237. Epub 2013 May 24.

PMID:
23710041
[PubMed - indexed for MEDLINE]
8.

Manganese-enhanced MRI of the rat visual pathway: acute neural toxicity, contrast enhancement, axon resolution, axonal transport, and clearance of Mn(2+).

Thuen M, Berry M, Pedersen TB, Goa PE, Summerfield M, Haraldseth O, Sandvig A, Brekken C.

J Magn Reson Imaging. 2008 Oct;28(4):855-65. doi: 10.1002/jmri.21504.

PMID:
18821627
[PubMed - indexed for MEDLINE]
9.

Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease.

Kins S, Lauther N, Szodorai A, Beyreuther K.

Neurodegener Dis. 2006;3(4-5):218-26. Review.

PMID:
17047360
[PubMed - indexed for MEDLINE]
10.

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.

Torres M, Jimenez S, Sanchez-Varo R, Navarro V, Trujillo-Estrada L, Sanchez-Mejias E, Carmona I, Davila JC, Vizuete M, Gutierrez A, Vitorica J.

Mol Neurodegener. 2012 Nov 22;7:59. doi: 10.1186/1750-1326-7-59.

PMID:
23173743
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Pharmacokinetics and amyloid plaque targeting ability of a novel peptide-based magnetic resonance contrast agent in wild-type and Alzheimer's disease transgenic mice.

Kandimalla KK, Wengenack TM, Curran GL, Gilles EJ, Poduslo JF.

J Pharmacol Exp Ther. 2007 Aug;322(2):541-9. Epub 2007 May 15.

PMID:
17505020
[PubMed - indexed for MEDLINE]
Free Article
12.

The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.

Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, Czech C, Hartmann T, Ida N, Multhaup G, Masters CL, Van Leuven F, Beyreuther K, Dotti CG.

EMBO J. 1996 Oct 1;15(19):5218-29.

PMID:
8895567
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.

Vagnoni A, Glennon EB, Perkinton MS, Gray EH, Noble W, Miller CC.

Hum Mol Genet. 2013 Nov 15;22(22):4646-52. doi: 10.1093/hmg/ddt313. Epub 2013 Jul 3.

PMID:
23825109
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

In vivo hippocampal microdialysis reveals impairment of NMDA receptor-cGMP signaling in APP(SW) and APP(SW)/PS1(L166P) Alzheimer's transgenic mice.

Duszczyk M, Kuszczyk M, Guridi M, Lazarewicz JW, Sadowski MJ.

Neurochem Int. 2012 Dec;61(7):976-80. doi: 10.1016/j.neuint.2012.07.017. Epub 2012 Jul 27.

PMID:
22841892
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

R-flurbiprofen improves axonal transport in the Tg2576 mouse model of Alzheimer's disease as determined by MEMRI.

Smith KD, Paylor R, Pautler RG.

Magn Reson Med. 2011 May;65(5):1423-9. doi: 10.1002/mrm.22733. Epub 2010 Dec 8.

PMID:
21500269
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI.

Kim J, Choi IY, Michaelis ML, Lee P.

Neuroimage. 2011 Jun 1;56(3):1286-92. doi: 10.1016/j.neuroimage.2011.02.039. Epub 2011 Feb 19.

PMID:
21338698
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease.

Hernandez CM, Kayed R, Zheng H, Sweatt JD, Dineley KT.

J Neurosci. 2010 Feb 17;30(7):2442-53. doi: 10.1523/JNEUROSCI.5038-09.2010.

PMID:
20164328
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Alzheimer's disease: an intracellular movement disorder?

Zhu X, Moreira PI, Smith MA, Perry G.

Trends Mol Med. 2005 Sep;11(9):391-3.

PMID:
16087404
[PubMed - indexed for MEDLINE]
19.

Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions.

van Groen T, Liu L, Ikonen S, Kadish I.

Neuroscience. 2003;119(4):1185-97.

PMID:
12831872
[PubMed - indexed for MEDLINE]
20.

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J.

J Neurosci. 2005 Jul 20;25(29):6755-64.

PMID:
16033885
[PubMed - indexed for MEDLINE]
Free Article

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