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Results: 1 to 20 of 122

1.

Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting.

van Meeteren LA, Thorikay M, Bergqvist S, Pardali E, Stampino CG, Hu-Lowe D, Goumans MJ, ten Dijke P.

J Biol Chem. 2012 May 25;287(22):18551-61. doi: 10.1074/jbc.M111.338103. Epub 2012 Apr 5.

PMID:
22493445
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells.

Upton PD, Davies RJ, Trembath RC, Morrell NW.

J Biol Chem. 2009 Jun 5;284(23):15794-804. doi: 10.1074/jbc.M109.002881. Epub 2009 Apr 14.

PMID:
19366699
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II.

Kim JH, Peacock MR, George SC, Hughes CC.

Angiogenesis. 2012 Sep;15(3):497-509. doi: 10.1007/s10456-012-9277-x. Epub 2012 May 24.

PMID:
22622516
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis.

Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao Q, Pukac L, Löwik CW, ten Dijke P.

J Cell Sci. 2007 Mar 15;120(Pt 6):964-72. Epub 2007 Feb 20.

PMID:
17311849
[PubMed - indexed for MEDLINE]
Free Article
5.

Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1.

Yao Y, Zebboudj AF, Shao E, Perez M, Boström K.

J Biol Chem. 2006 Nov 10;281(45):33921-30. Epub 2006 Sep 1.

PMID:
16950789
[PubMed - indexed for MEDLINE]
Free Article
6.

Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies.

Nolan-Stevaux O, Zhong W, Culp S, Shaffer K, Hoover J, Wickramasinghe D, Ruefli-Brasse A.

PLoS One. 2012;7(12):e50920. doi: 10.1371/journal.pone.0050920. Epub 2012 Dec 27.

PMID:
23300529
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex.

Townson SA, Martinez-Hackert E, Greppi C, Lowden P, Sako D, Liu J, Ucran JA, Liharska K, Underwood KW, Seehra J, Kumar R, Grinberg AV.

J Biol Chem. 2012 Aug 10;287(33):27313-25. doi: 10.1074/jbc.M112.377960. Epub 2012 Jun 20.

PMID:
22718755
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.

David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S.

Blood. 2007 Mar 1;109(5):1953-61. Epub 2006 Oct 26.

PMID:
17068149
[PubMed - indexed for MEDLINE]
Free Article
9.

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.

Cunha SI, Pardali E, Thorikay M, Anderberg C, Hawinkels L, Goumans MJ, Seehra J, Heldin CH, ten Dijke P, Pietras K.

J Exp Med. 2010 Jan 18;207(1):85-100. doi: 10.1084/jem.20091309. Epub 2010 Jan 11.

PMID:
20065063
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis.

Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S, Li E.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2626-31.

PMID:
10716993
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells.

Luo J, Tang M, Huang J, He BC, Gao JL, Chen L, Zuo GW, Zhang W, Luo Q, Shi Q, Zhang BQ, Bi Y, Luo X, Jiang W, Su Y, Shen J, Kim SH, Huang E, Gao Y, Zhou JZ, Yang K, Luu HH, Pan X, Haydon RC, Deng ZL, He TC.

J Biol Chem. 2010 Sep 17;285(38):29588-98. doi: 10.1074/jbc.M110.130518. Epub 2010 Jul 13.

PMID:
20628059
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Bone morphogenetic protein-9 is a circulating vascular quiescence factor.

David L, Mallet C, Keramidas M, Lamandé N, Gasc JM, Dupuis-Girod S, Plauchu H, Feige JJ, Bailly S.

Circ Res. 2008 Apr 25;102(8):914-22. doi: 10.1161/CIRCRESAHA.107.165530. Epub 2008 Feb 28.

PMID:
18309101
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling.

Ricard N, Ciais D, Levet S, Subileau M, Mallet C, Zimmers TA, Lee SJ, Bidart M, Feige JJ, Bailly S.

Blood. 2012 Jun 21;119(25):6162-71. doi: 10.1182/blood-2012-01-407593. Epub 2012 May 7.

PMID:
22566602
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth.

Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, Seehra J, Kumar R.

Mol Cancer Ther. 2010 Feb;9(2):379-88. doi: 10.1158/1535-7163.MCT-09-0650. Epub 2010 Feb 2.

PMID:
20124460
[PubMed - indexed for MEDLINE]
Free Article
15.

Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction.

Lebrin F, Goumans MJ, Jonker L, Carvalho RL, Valdimarsdottir G, Thorikay M, Mummery C, Arthur HM, ten Dijke P.

EMBO J. 2004 Oct 13;23(20):4018-28. Epub 2004 Sep 23.

PMID:
15385967
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies.

Hu-Lowe DD, Chen E, Zhang L, Watson KD, Mancuso P, Lappin P, Wickman G, Chen JH, Wang J, Jiang X, Amundson K, Simon R, Erbersdobler A, Bergqvist S, Feng Z, Swanson TA, Simmons BH, Lippincott J, Casperson GF, Levin WJ, Stampino CG, Shalinsky DR, Ferrara KW, Fiedler W, Bertolini F.

Cancer Res. 2011 Feb 15;71(4):1362-73. doi: 10.1158/0008-5472.CAN-10-1451. Epub 2011 Jan 6.

PMID:
21212415
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells.

Shao ES, Lin L, Yao Y, Boström KI.

Blood. 2009 Sep 3;114(10):2197-206. doi: 10.1182/blood-2009-01-199166. Epub 2009 Jun 8.

PMID:
19506300
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.

Somekawa S, Imagawa K, Hayashi H, Sakabe M, Ioka T, Sato GE, Inada K, Iwamoto T, Mori T, Uemura S, Nakagawa O, Saito Y.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12064-9. doi: 10.1073/pnas.1207210109. Epub 2012 Jul 10.

PMID:
22783020
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression.

Yoshimatsu Y, Lee YG, Akatsu Y, Taguchi L, Suzuki HI, Cunha SI, Maruyama K, Suzuki Y, Yamazaki T, Katsura A, Oh SP, Zimmers TA, Lee SJ, Pietras K, Koh GY, Miyazono K, Watabe T.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18940-5. doi: 10.1073/pnas.1310479110. Epub 2013 Oct 16.

PMID:
24133138
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.

Ray BN, Lee NY, How T, Blobe GC.

Carcinogenesis. 2010 Mar;31(3):435-41. doi: 10.1093/carcin/bgp327. Epub 2009 Dec 30.

PMID:
20042635
[PubMed - indexed for MEDLINE]
Free PMC Article
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