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Items: 1 to 20 of 107

1.

A new model of Pde4d deficiency: genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects.

Schaefer TL, Braun AA, Amos-Kroohs RM, Williams MT, Ostertag E, Vorhees CV.

Genes Brain Behav. 2012 Jul;11(5):614-22. doi: 10.1111/j.1601-183X.2012.00796.x. Epub 2012 May 8.

2.

RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects.

Wang ZZ, Zhang Y, Liu YQ, Zhao N, Zhang YZ, Yuan L, An L, Li J, Wang XY, Qin JJ, Wilson SP, O'Donnell JM, Zhang HT, Li YF.

Br J Pharmacol. 2013 Feb;168(4):1001-14. doi: 10.1111/j.1476-5381.2012.02225.x.

3.

Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.

Li YF, Cheng YF, Huang Y, Conti M, Wilson SP, O'Donnell JM, Zhang HT.

J Neurosci. 2011 Jan 5;31(1):172-83. doi: 10.1523/JNEUROSCI.5236-10.2011.

4.

Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D) mice.

Rutten K, Misner DL, Works M, Blokland A, Novak TJ, Santarelli L, Wallace TL.

Eur J Neurosci. 2008 Aug;28(3):625-32. doi: 10.1111/j.1460-9568.2008.06349.x.

PMID:
18702734
5.

Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme.

Zhang HT, Huang Y, Jin SL, Frith SA, Suvarna N, Conti M, O'Donnell JM.

Neuropsychopharmacology. 2002 Oct;27(4):587-95.

6.

Extinction-induced "despair" in the water maze, exploratory behavior and fear: effects of chronic antidepressant treatment.

Schulz D, Buddenberg T, Huston JP.

Neurobiol Learn Mem. 2007 May;87(4):624-34. Epub 2007 Jan 16.

PMID:
17223365
7.

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.

Sierksma AS, van den Hove DL, Pfau F, Philippens M, Bruno O, Fedele E, Ricciarelli R, Steinbusch HW, Vanmierlo T, Prickaerts J.

Neuropharmacology. 2014 Feb;77:120-30. doi: 10.1016/j.neuropharm.2013.09.015. Epub 2013 Sep 22.

PMID:
24067928
8.

Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice.

Callaerts-Vegh Z, Beckers T, Ball SM, Baeyens F, Callaerts PF, Cryan JF, Molnar E, D'Hooge R.

J Neurosci. 2006 Jun 14;26(24):6573-82.

9.

Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders.

Wurzman R, Forcelli PA, Griffey CJ, Kromer LF.

Behav Brain Res. 2015 Feb 1;278:115-28. doi: 10.1016/j.bbr.2014.09.012. Epub 2014 Oct 2.

10.

Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior.

Hansen RT 3rd, Conti M, Zhang HT.

Psychopharmacology (Berl). 2014 Aug;231(15):2941-54. doi: 10.1007/s00213-014-3480-y. Epub 2014 Feb 22.

PMID:
24563185
11.

Neurobehavioral phenotype of C57BL/6J mice prenatally and neonatally exposed to cigarette smoke.

Amos-Kroohs RM, Williams MT, Braun AA, Graham DL, Webb CL, Birtles TS, Greene RM, Vorhees CV, Pisano MM.

Neurotoxicol Teratol. 2013 Jan-Feb;35:34-45. doi: 10.1016/j.ntt.2013.01.001. Epub 2013 Jan 11.

12.

Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme.

Siuciak JA, McCarthy SA, Chapin DS, Martin AN.

Psychopharmacology (Berl). 2008 Mar;197(1):115-26. Epub 2007 Dec 1.

PMID:
18060387
13.

Autophosphorylation of alphaCaMKII is differentially involved in new learning and unlearning mechanisms of memory extinction.

Kimura R, Silva AJ, Ohno M.

Learn Mem. 2008 Oct 30;15(11):837-43. doi: 10.1101/lm.1049608. Print 2008 Nov.

14.

Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).

Zhang HT, Huang Y, Masood A, Stolinski LR, Li Y, Zhang L, Dlaboga D, Jin SL, Conti M, O'Donnell JM.

Neuropsychopharmacology. 2008 Jun;33(7):1611-23. Epub 2007 Aug 15.

15.

Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice.

Horii Y, Yamasaki N, Miyakawa T, Shiosaka S.

Behav Neurosci. 2008 Jun;122(3):498-504. doi: 10.1037/0735-7044.122.3.498.

PMID:
18513120
16.

Enhancement of acoustic prepulse inhibition by contextual fear conditioning in mice is maintained even after contextual fear extinction.

Ishii D, Matsuzawa D, Fujita Y, Sutoh C, Ohtsuka H, Matsuda S, Kanahara N, Hashimoto K, Iyo M, Shimizu E.

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):183-8. doi: 10.1016/j.pnpbp.2009.10.023. Epub 2009 Nov 14.

PMID:
19922757
17.
18.

Affective and cognitive effects of global deletion of alpha3-containing gamma-aminobutyric acid-A receptors.

Fiorelli R, Rudolph U, Straub CJ, Feldon J, Yee BK.

Behav Pharmacol. 2008 Sep;19(5-6):582-96. doi: 10.1097/FBP.0b013e32830dc0c7.

PMID:
18690113
20.

Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: implications for role of relaxin-3/RXFP3 signalling in sustained arousal.

Hosken IT, Sutton SW, Smith CM, Gundlach AL.

Behav Brain Res. 2015 Feb 1;278:167-75. doi: 10.1016/j.bbr.2014.09.028. Epub 2014 Sep 22.

PMID:
25257104
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