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Results: 1 to 20 of 111

1.

G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition.

So CH, Michal AM, Mashayekhi R, Benovic JL.

J Biol Chem. 2012 May 18;287(21):17088-99. doi: 10.1074/jbc.M112.353854. Epub 2012 Mar 30.

PMID:
22467873
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression.

Michal AM, So CH, Beeharry N, Shankar H, Mashayekhi R, Yen TJ, Benovic JL.

J Biol Chem. 2012 Feb 24;287(9):6928-40. doi: 10.1074/jbc.M111.298034. Epub 2012 Jan 5.

PMID:
22223642
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus.

Vazquez-Martin A, Oliveras-Ferraros C, Cufí S, Menendez JA.

Cell Cycle. 2011 Apr 15;10(8):1295-302. Epub 2011 Apr 15.

PMID:
21474997
[PubMed - indexed for MEDLINE]
Free Article
4.

Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1).

Kreis NN, Sommer K, Sanhaji M, Krämer A, Matthess Y, Kaufmann M, Strebhardt K, Yuan J.

Cell Cycle. 2009 Feb 1;8(3):460-72. Epub 2009 Feb 18.

PMID:
19177004
[PubMed - indexed for MEDLINE]
Free Article
5.

Centrosomal protein 55 (Cep55) stability is negatively regulated by p53 protein through Polo-like kinase 1 (Plk1).

Chang YC, Wu CH, Yen TC, Ouyang P.

J Biol Chem. 2012 Feb 3;287(6):4376-85. doi: 10.1074/jbc.M111.289108. Epub 2011 Dec 19.

PMID:
22184120
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions.

Reindl W, Yuan J, Krämer A, Strebhardt K, Berg T.

Chem Biol. 2008 May;15(5):459-66. doi: 10.1016/j.chembiol.2008.03.013.

PMID:
18482698
[PubMed - indexed for MEDLINE]
Free Article
7.

 p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors.

Sanhaji M, Kreis NN, Zimmer B, Berg T, Louwen F, Yuan J.

Cell Cycle. 2012 Feb 1;11(3):543-53. doi: 10.4161/cc.11.3.19076. Epub 2012 Feb 1.

PMID:
22262171
[PubMed - indexed for MEDLINE]
8.

Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1.

Higashimoto T, Chan N, Lee YK, Zandi E.

J Biol Chem. 2008 Dec 19;283(51):35354-67. doi: 10.1074/jbc.M806258200. Epub 2008 Oct 27.

PMID:
18957422
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Polo-like kinase 1 (Plk1) is expressed by cutaneous T-cell lymphomas (CTCLs), and its downregulation promotes cell cycle arrest and apoptosis.

Nihal M, Stutz N, Schmit T, Ahmad N, Wood GS.

Cell Cycle. 2011 Apr 15;10(8):1303-11. Epub 2011 Apr 15.

PMID:
21436619
[PubMed - indexed for MEDLINE]
Free Article
10.

Requirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1).

Chi YH, Haller K, Ward MD, Semmes OJ, Li Y, Jeang KT.

J Biol Chem. 2008 Dec 19;283(51):35834-44. doi: 10.1074/jbc.M804967200. Epub 2008 Oct 15.

PMID:
18922800
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages.

Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL.

J Biol Chem. 2006 Nov 10;281(45):34159-70. Epub 2006 Sep 15.

PMID:
16980301
[PubMed - indexed for MEDLINE]
Free Article
12.

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

Lansing TJ, McConnell RT, Duckett DR, Spehar GM, Knick VB, Hassler DF, Noro N, Furuta M, Emmitte KA, Gilmer TM, Mook RA Jr, Cheung M.

Mol Cancer Ther. 2007 Feb;6(2):450-9. Epub 2007 Jan 31.

PMID:
17267659
[PubMed - indexed for MEDLINE]
Free Article
13.

A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies.

Ikezoe T, Yang J, Nishioka C, Takezaki Y, Tasaka T, Togitani K, Koeffler HP, Yokoyama A.

Leukemia. 2009 Sep;23(9):1564-76. doi: 10.1038/leu.2009.94. Epub 2009 May 7.

PMID:
19421227
[PubMed - indexed for MEDLINE]
14.

Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.

Lee C, Fotovati A, Triscott J, Chen J, Venugopal C, Singhal A, Dunham C, Kerr JM, Verreault M, Yip S, Wakimoto H, Jones C, Jayanthan A, Narendran A, Singh SK, Dunn SE.

Stem Cells. 2012 Jun;30(6):1064-75. doi: 10.1002/stem.1081.

PMID:
22415968
[PubMed - indexed for MEDLINE]
Free Article
15.

Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation.

Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, Okoshi R, Kamijo T, Omura K, Nakagawara A.

J Biol Chem. 2008 Mar 28;283(13):8555-63. doi: 10.1074/jbc.M710608200. Epub 2008 Jan 3.

PMID:
18174154
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation.

Li L, Wang X, Chen J, Ding H, Zhang Y, Hu TC, Hu LH, Jiang HL, Shen X.

Acta Pharmacol Sin. 2009 Oct;30(10):1443-53. doi: 10.1038/aps.2009.141.

PMID:
19801998
[PubMed - indexed for MEDLINE]
Free Article
17.

Dissecting the phenotypes of Plk1 inhibition in cancer cells using novel kinase inhibitory chemical CBB2001.

Lan R, Lin G, Yin F, Xu J, Zhang X, Wang J, Wang Y, Gong J, Ding YH, Yang Z, Lu F, Zhang H.

Lab Invest. 2012 Oct;92(10):1503-14. doi: 10.1038/labinvest.2012.114. Epub 2012 Aug 13.

PMID:
22890557
[PubMed - indexed for MEDLINE]
Free Article
18.

Enabling and disabling polo-like kinase 1 inhibition through chemical genetics.

Burkard ME, Santamaria A, Jallepalli PV.

ACS Chem Biol. 2012 Jun 15;7(6):978-81. doi: 10.1021/cb200551p. Epub 2012 Mar 20.

PMID:
22422077
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.

Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G.

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17818-23. doi: 10.1073/pnas.0804446105. Epub 2008 Nov 13.

PMID:
19008357
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.

Chen X, Zhu H, Yuan M, Fu J, Zhou Y, Ma L.

J Biol Chem. 2010 Apr 23;285(17):12823-30. doi: 10.1074/jbc.M109.094243. Epub 2010 Feb 2.

PMID:
20124405
[PubMed - indexed for MEDLINE]
Free PMC Article

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