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Sirtuins as regulators of the yeast metabolic network.

Ralser M, Michel S, Breitenbach M.

Front Pharmacol. 2012 Mar 8;3:32. doi: 10.3389/fphar.2012.00032. eCollection 2012.


Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction.

Lu SP, Lin SJ.

Biochim Biophys Acta. 2010 Aug;1804(8):1567-75. doi: 10.1016/j.bbapap.2009.09.030. Epub 2009 Oct 8. Review.


Yeast sirtuins and the regulation of aging.

Wierman MB, Smith JS.

FEMS Yeast Res. 2014 Feb;14(1):73-88. doi: 10.1111/1567-1364.12115. Epub 2013 Nov 14. Review.


Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.

Lu SP, Kato M, Lin SJ.

J Biol Chem. 2009 Jun 19;284(25):17110-9. doi: 10.1074/jbc.M109.004010. Epub 2009 May 5.


Sirtuins and their relevance to the kidney.

Hao CM, Haase VH.

J Am Soc Nephrol. 2010 Oct;21(10):1620-7. doi: 10.1681/ASN.2010010046. Epub 2010 Jul 1. Review.


Small molecule regulation of Sir2 protein deacetylases.

Grubisha O, Smith BC, Denu JM.

FEBS J. 2005 Sep;272(18):4607-16. Review.


Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.

J Biol Chem. 2002 Nov 22;277(47):45099-107. Epub 2002 Sep 23.


NAD⁺ metabolism: a therapeutic target for age-related metabolic disease.

Mouchiroud L, Houtkooper RH, Auwerx J.

Crit Rev Biochem Mol Biol. 2013 Jul-Aug;48(4):397-408. doi: 10.3109/10409238.2013.789479. Epub 2013 Jun 6. Review.


Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast.

Posakony J, Hirao M, Bedalov A.

Comb Chem High Throughput Screen. 2004 Nov;7(7):661-8. Review.


Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.

Imai S, Guarente L.

Trends Pharmacol Sci. 2010 May;31(5):212-20. doi: 10.1016/ Epub 2010 Mar 11. Review.


"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging.

Imai S.

Biochim Biophys Acta. 2010 Aug;1804(8):1584-90. doi: 10.1016/j.bbapap.2009.10.024. Epub 2009 Nov 6. Review.


The anti-aging, metabolism potential of SIRT1.

Ghosh HS.

Curr Opin Investig Drugs. 2008 Oct;9(10):1095-102. Review.


The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.

Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, Sternglanz R.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5807-11.


A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

Smith JS, Brachmann CB, Celic I, Kenna MA, Muhammad S, Starai VJ, Avalos JL, Escalante-Semerena JC, Grubmeyer C, Wolberger C, Boeke JD.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6658-63.


The sirtuins: Markers of metabolic health.

Covington JD, Bajpeyi S.

Mol Nutr Food Res. 2016 Jan;60(1):79-91. doi: 10.1002/mnfr.201500340. Epub 2015 Dec 7. Review.


Interfering with glycolysis causes Sir2-dependent hyper-recombination of Saccharomyces cerevisiae plasmids.

Ralser M, Zeidler U, Lehrach H.

PLoS One. 2009;4(4):e5376. doi: 10.1371/journal.pone.0005376. Epub 2009 Apr 24.


Sirtuins: the 'magnificent seven', function, metabolism and longevity.

Dali-Youcef N, Lagouge M, Froelich S, Koehl C, Schoonjans K, Auwerx J.

Ann Med. 2007;39(5):335-45. Review.


Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases.

Zhao K, Harshaw R, Chai X, Marmorstein R.

Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8563-8. Epub 2004 May 18.


SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions.

Zhang T, Kraus WL.

Biochim Biophys Acta. 2010 Aug;1804(8):1666-75. doi: 10.1016/j.bbapap.2009.10.022. Epub 2009 Oct 30. Review.


Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C.

Cell. 2007 May 4;129(3):473-84.

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