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Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.

Zhang L, Das P, Schmolke M, Manicassamy B, Wang Y, Deng X, Cai L, Tu BP, Forst CV, Roth MG, Levy DE, García-Sastre A, de Brabander J, Phillips MA, Fontoura BM.

J Cell Biol. 2012 Feb 6;196(3):315-26. doi: 10.1083/jcb.201107058.


Nuclear functions of the influenza A and B viruses NS1 proteins: do they play a role in viral mRNA export?

Schneider J, Wolff T.

Vaccine. 2009 Oct 23;27(45):6312-6. doi: 10.1016/j.vaccine.2009.01.015. Review.


Influenza virus targets the mRNA export machinery and the nuclear pore complex.

Satterly N, Tsai PL, van Deursen J, Nussenzveig DR, Wang Y, Faria PA, Levay A, Levy DE, Fontoura BM.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1853-8. Epub 2007 Jan 31.


The regulation of export of mRNA from nucleus to cytoplasm.

Krug RM.

Curr Opin Cell Biol. 1993 Dec;5(6):944-9. Review.


Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export.

Read EK, Digard P.

J Gen Virol. 2010 May;91(Pt 5):1290-301. doi: 10.1099/vir.0.018564-0. Epub 2010 Jan 13.


The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication.

de Chassey B, Aublin-Gex A, Ruggieri A, Meyniel-Schicklin L, Pradezynski F, Davoust N, Chantier T, Tafforeau L, Mangeot PE, Ciancia C, Perrin-Cocon L, Bartenschlager R, André P, Lotteau V.

PLoS Pathog. 2013;9(7):e1003440. doi: 10.1371/journal.ppat.1003440. Epub 2013 Jul 4.


The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing.

Lu Y, Qian XY, Krug RM.

Genes Dev. 1994 Aug 1;8(15):1817-28.


Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis.

Salvatore M, Basler CF, Parisien JP, Horvath CM, Bourmakina S, Zheng H, Muster T, Palese P, García-Sastre A.

J Virol. 2002 Feb;76(3):1206-12.


Influenza C virus NS1 protein upregulates the splicing of viral mRNAs.

Muraki Y, Furukawa T, Kohno Y, Matsuzaki Y, Takashita E, Sugawara K, Hongo S.

J Virol. 2010 Feb;84(4):1957-66. doi: 10.1128/JVI.01627-09. Epub 2009 Dec 9.


Biogenesis, assembly, and export of viral messenger ribonucleoproteins in the influenza A virus infected cell.

York A, Fodor E.

RNA Biol. 2013 Aug;10(8):1274-82. doi: 10.4161/rna.25356. Epub 2013 Jun 17. Review.


Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication.

Boyne JR, Colgan KJ, Whitehouse A.

PLoS Pathog. 2008 Oct;4(10):e1000194. doi: 10.1371/journal.ppat.1000194. Epub 2008 Oct 31.


Selective nuclear export of viral mRNAs in influenza-virus-infected cells.

Chen Z, Krug RM.

Trends Microbiol. 2000 Aug;8(8):376-83. Review.


Role of nucleoporin induction in releasing an mRNA nuclear export block.

Enninga J, Levy DE, Blobel G, Fontoura BM.

Science. 2002 Feb 22;295(5559):1523-5. Epub 2002 Jan 24.

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